2010
DOI: 10.1016/j.jss.2009.11.571
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The Glucogram: A New Quantitative Tool for Glycemic Analysis in the Surgical Intensive Care Unit

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“…Insulin administration has been shown to improve muscle protein synthesis, normalize mitochondrial function, reduce oxidative stress, limit lean muscle mass loss, accelerate healing time, and improve long-term rehabilitation [176][177][178][179]. In addition to the normalization of serum glucose levels, the reduction in glycemic variability may be equally important [180,181]. Other beneficial effects of goal-directed insulin therapy have been identified, including potential reductions in mortality, infections, sepsis, acute kidney injury, multiple organ failure, days on a ventilator, and hospital length of stay [177,178,182].…”
Section: The Importance Of Endocrine System Including Glycemic Controlmentioning
confidence: 99%
“…Insulin administration has been shown to improve muscle protein synthesis, normalize mitochondrial function, reduce oxidative stress, limit lean muscle mass loss, accelerate healing time, and improve long-term rehabilitation [176][177][178][179]. In addition to the normalization of serum glucose levels, the reduction in glycemic variability may be equally important [180,181]. Other beneficial effects of goal-directed insulin therapy have been identified, including potential reductions in mortality, infections, sepsis, acute kidney injury, multiple organ failure, days on a ventilator, and hospital length of stay [177,178,182].…”
Section: The Importance Of Endocrine System Including Glycemic Controlmentioning
confidence: 99%
“…[ 1 ] Glucose dysregulation may be related, in part, to transport practices such as discontinuation of insulin pumps and alterations in intravenous fluid infusions during transport. Because the degree of glycemic control and the associated glycemic variability both correlate with patient outcomes,[ 48 49 ] close attention should be paid to glucose regulation during all phases of patient care, including IHTs. [ 50 ] It is advisable for clinical teams to include glycemic control as an integral part of pre-IHT debriefing.…”
Section: Hypoglycemia and Hyperglycemiamentioning
confidence: 99%