The glucocorticoid receptor is a critical regulator of muscle satellite cell quiescence
Rashida Rajgara,
Hamood AlSudais,
Aisha Saleh
et al.
Abstract:Glucocorticoids are powerful anti-inflammatory medications that are associated with muscle atrophy. The effect of glucocorticoids in myofibers is well-studied, yet the role of the glucocorticoid receptor (GR), the primary mediator of glucocorticoid transcriptional responses, and the impact of glucocorticoid signalling in muscle stem cells (MuSCs), the adult progenitors responsible for regeneration, remain unknown. We developed a conditional null mouse model to knock out glucocorticoid receptor (GR) expression … Show more
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