2012
DOI: 10.1016/j.atherosclerosis.2011.12.039
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The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells

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Cited by 226 publications
(152 citation statements)
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“…Experimental studies have demonstrated that GLP‐1 agonists have anti‐inflammatory effects on endothelial cells. Treatment with the GLP‐1 receptor agonist liraglutide inhibited tumor necrosis factor‐α, intracellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 in human endothelial cells 66, 67. In animal models, liraglutide has been shown to reduce serum levels of several inflammatory markers such us C‐reactive protein, interleukin‐6, tumor necrosis factor‐α and the plasmin plasminogen activator inhibitor‐1 68…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies have demonstrated that GLP‐1 agonists have anti‐inflammatory effects on endothelial cells. Treatment with the GLP‐1 receptor agonist liraglutide inhibited tumor necrosis factor‐α, intracellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 in human endothelial cells 66, 67. In animal models, liraglutide has been shown to reduce serum levels of several inflammatory markers such us C‐reactive protein, interleukin‐6, tumor necrosis factor‐α and the plasmin plasminogen activator inhibitor‐1 68…”
Section: Discussionmentioning
confidence: 99%
“…Mice were given 10 µg/kg exendin-4, and after 48 wk of treatment, results showed that activation of NF-κB was reduced; exendin-4 also significantly inhibited the binding activity of NFκBp65 in patients with diabetes mellitus [45] . Liraglutide significantly inhibited NF-κB activation and up-regulated the IκB family of proteins while phosphorylation of IKK-α/β, which is upstream of NF-κB signaling, was also down-regulated after 15 min of TNF-α treatment [73] . ERK 1/2 and PI3-K/AKT are involved in LPS-induced NF-κB activation [74,75] .…”
Section: Glp-1ras and Inflammatory Signal Transduction Pathwaysmentioning
confidence: 94%
“…Furthermore, recent studies have shown that GLP-1 reduces inflammation and oxidative stress in endothelial cells (11,12). The importance of GLP-1 in glucose homeostasis is emphasized by the inhibitors of dipeptidyl peptidase-4 (DPP-4); enzymes which have been found to exert positive effects on cardioprotection in previous studies (13,14).…”
Section: Introductionmentioning
confidence: 99%