The glomerulopathy of congenital syphilis—an immune deposit disease

Kaplan, B.; Wiglesworth, F. W.; Marks, Melvin I.; Drummond, Keith N.

doi:10.1016/s0022-3476(72)80251-8

Cited by 54 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pregnancy was, however, uncomplicated by any obvious infection and, furthermore, we found no antibodies to any of the viruses that are investigated routinely. Tests for syphilis and toxoplasmosis were also negative [17]. As the amniotic fluid was clear, a bacterial infection during pregnancy, resulting in crescentic glomerulonephritis [18,19], seemed to be unlikely in our patient.…”

Section: Discussionmentioning

confidence: 70%

A case of atypical congenital nephrotic syndrome

Świetliński

Maruniak‐Chudek

Niemir

et al. 2004

Pediatric Nephrology

View full text Add to dashboard Cite

We present a female newborn with the nephrotic syndrome of intrauterine onset and a unique set of extrarenal abnormalities, as well as atypical renal lesions. The extrarenal anomalies comprised a soft tissue hemangioma in the frontotemporal region, unilateral microphthalmia (with persistent hyperplastic corpus vitreous and detachment of the retina), and glaucoma in the other eye. Immature glomeruli and/or glomeruli with large cellular crescents were found in renal biopsy specimens in the 3rd week of life. On autopsy, 7 weeks later, diffuse mesangial sclerosis (DMS) was the predominant type of glomerular lesion. In addition, dilations of tubules, forming microcysts, as well as clusters of infiltrating cells in the interstitium, were found both in renal biopsy and autopsy specimens. Although the symptoms observed in our patient did not match any reported in association with the known forms of the congenital nephrotic syndrome (CNS), the most probable diagnosis seemed to be CNS due to DMS of intrauterine onset, with superimposed drug-related tubulointerstitial nephritis.

show abstract

Section: Discussionmentioning

confidence: 70%

A case of atypical congenital nephrotic syndrome

Świetliński

Maruniak‐Chudek

Niemir

et al. 2004

Pediatric Nephrology

View full text Add to dashboard Cite

show abstract

“…He had no extrarenal manifestations of neonatal infections associated with nephrotic syndrome [7][8][9] nor of systemic lupus [10], Denys-Drash syndrome [11], or GallowayMowat syndrome [12]. Although the finding of hypothyroidism in the neonatal period may have been caused by early onset nephrotic syndrome [13], the age of presentation of edema and the renal histopathological findings were not typical for congenital nephrotic syndrome of the Finnish type [14].…”

Section: Discussionmentioning

confidence: 99%

Nephrotic syndrome at 5 months: no definitive treatment or complications for 12 years

Garza

Guttenberg

Kaplan

1999

Pediatric Nephrology

View full text Add to dashboard Cite

We describe a patient who developed nephrotic syndrome at 5 months, with extensive glomerular and tubular damage on biopsy. The patient was treated with diuretics and was asymptomatic for a decade despite unremitting proteinuria. A repeat biopsy at 13 years of age showed remarkable healing with histopathological features consistent with "minimal change" nephrotic syndrome. This patient illustrates a favorable clinical outcome, without specific treatment, of nephrotic syndrome of long duration.

show abstract

“…Membranous glomerulonephritis (MGN), as seen in this case, is the most commonly observed histopathological lesion, and is thought to be mediated by immune complex deposition within the capillary walls [3][4][5][6][7][8][9]. Renal function is normal in most cases, but this case is reported to involve acute kidney injury (AKI).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous nephrotic syndrome and hepatitis in secondary syphilis: case report and review of the literature

et al. 2015

View full text Add to dashboard Cite

A 66-year-old man presented with a penile ulcer, an acute clinical onset of nephrotic syndrome and hepatitis. Secondary syphilis was diagnosed on the basis of the history of rash and the result of strongly positive serological test for syphilis. A renal biopsy demonstrated membranous glomerulonephritis with subepithelial electron-dense deposits. After treatment with amoxicillin for 2 weeks, he achieved clinical recovery. It is important to recognize syphilis as a reversible cause of nephrotic syndrome and acute hepatitis because antibiotic therapy can result in complete remission.

show abstract

The glomerulopathy of congenital syphilis—an immune deposit disease

Cited by 54 publications

References 13 publications

A case of atypical congenital nephrotic syndrome

A case of atypical congenital nephrotic syndrome

Nephrotic syndrome at 5 months: no definitive treatment or complications for 12 years

Simultaneous nephrotic syndrome and hepatitis in secondary syphilis: case report and review of the literature

Contact Info

Product

Resources

About