The Glomerulopathy of Congenital Syphilis

Yuceoglu, A. M.

doi:10.1001/jama.1974.03230460035018

Cited by 18 publications

(3 citation statements)

References 8 publications

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“…Divergent studies (14,41,46,47) have shown that patients with secondary syphilis have high levels of circulating immune complexes (IC). Additional studies, certain of which have demonstrated treponemal antigens and immunoglobulin G (IgG) in glomeruli, have suggested that IC play a role in the pathogenesis of the glomerulonephritis associated with congenital and secondary syphilis in humans (9,11,15,16,24,29,42,43,48). Similarly, IC may contribute to the development of the skin lesions seen in secondary syphilis (19,41).…”

mentioning

confidence: 99%

Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes

Baughn¹,

Adams²,

Musher³

1983

Infect Immun

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As a prelude to characterization of the host and treponemal antigens present in purified immune complexes from the sera of rabbits with disseminated syphilis, autoradiographic and immunoenzymatic analyses of solubilized extracts of Treponema pallidum, Treponema phagedenis biotype Reiter, and Treponema refringens were performed on electroblots of polypeptides first separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Electroblots of purified immune complexes were developed with the same panel of antisera so that protein profiles could be compared. Eight treponemal antigens were consistently present in isolated complexes; four of these cross-reacted with antisera prepared against avirulent treponemes. The average molecular weights of these antigens were 87,000, 76,000, 66,000, and 45,000. Antibodies dissociated from isolated immune complexes, when used for the development of T. pallidum electroblots, reacted with four antigens of comparable molecular weight. Antibodies to those polypeptides were also present in the sera of animals immunized with immune complexes. The demonstration of treponemal antigens in purified immune complexes convincingly argues that their occurrence in experimental syphilis is not merely due to tissue destruction and responses to endogenous host antigens.

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confidence: 99%

Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes

Baughn¹,

Adams²,

Musher³

1983

Infect Immun

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“…The roles of CIC and RF in the pathogenesis of experimental congenital syphilis have, so far, not been explored. In human congenital syphilis, CIC have been associated with glomerulonephritis (19,23,32,40), and IgM antibodies directed against IgG (RF) have been detected in several congenital infections including congenital syphilis (7,8,30).…”

Section: Discussionmentioning

confidence: 99%

Experimental congenital syphilis: guinea pig model

et al. 1992

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Neonates born to female guinea pigs of either a highly susceptible (C4D) or a resistant (Albany) strain, infected prior to or during pregnancy with a single dose of Treponema pallidum, showed in their sera from the first day of life immunoglobulin M (IgM) antibodies to T. paLlidum, circulating immune complexes consisting of IgM antibodies and treponemal antigens, and IgM rheumatoid factor. Although the animals were asymptomatic for a 6-month observation period, several lines of evidence indicated that they were infected in utero. Molecular analysis of whole sera, purified serum IgM fraction, or dissociated immune complexes demonstrated IgM reactivity against one (47 kDa) or more of several T. pallidum peptides (15, 17, 37, 42, 45, and 87 kDa) recognized as integral membrane components. Sequential analysis of the neonates' sera by immunoblot and enzyme-linked immunosorbent assay, using alcohol-treated T. pallidum, T. phagedenis biotype Reiter, and T. vincentii, demonstrated early IgM antibodies followed 3 to 4 months later by IgG2-and IgGl-specific antibodies to T. pallidum. Moreover, an infectivity test done in five rabbits with pooled tissue extracts prepared from liveborn or stillborn animals evoked a seroconversion in two rabbits (reactive Venereal Disease Research Laboratory and fluorescent treponemal antibody tests), suggesting the presence of T. paUidum in the organs. Sera from neonates born to either T. phagedenis biotype Reiter-injected mothers or three normal pregnant females were all serologically negative. The model offers new possibilities for exploration of factors responsible for asymptomatic infection often observed in human congenital syphilis.

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“…Dobson, Taber and I in 1985 decided to focus our attention on assessment of the pathogenic significance of circulating im mune complexes (CIC) in newborn infants with congenital syphilis. Although CIC had only been implicated in the context of an uncommon complication, such as glomeru lonephritis [71][72][73][74], we felt that certain im mune events, especially the induction of IgM-RF to maternal IgG. favored formation of complexes.…”

Section: Pathogenesis: a Need To Understand The Ontogeny And Impact Omentioning

confidence: 99%

Congenital Syphilis: Immunologic Challenges

Baughn¹

1989

Path Immunopathol Res

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The Glomerulopathy of Congenital Syphilis

Cited by 18 publications

References 8 publications

Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes

Circulating immune complexes in experimental syphilis: identification of treponemal antigens and specific antibodies to treponemal antigens in isolated complexes

Experimental congenital syphilis: guinea pig model

Congenital Syphilis: Immunologic Challenges

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