The globalization of leptospirosis: worldwide incidence trends

Pappas, Georgios; Papadimitriou, Photini; Siozopoulou, Vasiliki; Christou, Leonidas; Akritidis, Nikolaos

doi:10.1016/j.ijid.2007.09.011

Cited by 454 publications

(394 citation statements)

References 34 publications

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“…Moreover, leptospirosis is associated with floodwaters following monsoons [11][12][13]. It has also been suggested that temperature and rainfall considerably increase the incidence of DF infections [14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Sumi

Telan²,

Chagan-Yasutan

et al. 2016

Epidemiol. Infect.

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SUMMARYDengue fever (DF) and leptospirosis are serious public problems in tropical regions, especially in Manila, the Philippines. In attempting to understand the causes of DF and leptospirosis seasonality, meteorological factors have been suspected, but quantitative correlation between seasonality and meteorological factors has not been fully investigated. In this study, we investigated correlation of temporal patterns of reported numbers of laboratory-confirmed cases of both DF and leptospirosis with meteorological conditions (temperature, relative humidity, rainfall) in Manila. We used time-series analysis combined with spectral analysis and the least squares method. A 1-year cycle explained underlying variations of DF, leptospirosis and meteorological data. There was a peak of the 1-year cycle in temperature during May, followed by maxima in rainfall, relative humidity and number of laboratory-confirmed DF and leptospirosis cases. This result suggests that DF and leptospirosis epidemics are correlated not only with rainfall but also relative humidity and temperature in the Philippines. Quantifying the correlation of DF and leptospirosis infections with meteorological conditions may prove useful in predicting DF and leptospirosis epidemics, and health services should plan accordingly.

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Section: Introductionmentioning

confidence: 99%

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Sumi

Telan²,

Chagan-Yasutan

et al. 2016

Epidemiol. Infect.

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“…1 The annual incidence is estimated at 10-100 cases per 100,000 population in tropical countries. 2 The early phase of leptospirosis manifestations lasts 3-7 days and includes fever, headaches, myalgia (especially in the calves), nausea, vomiting, malaise, and conjunctival hyperemia. Only 10% progress to the second phase: the Weil syndrome.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Glycocalyx Damage is Associated with Leptospirosis Acute Kidney Injury

Libório¹,

Braz²,

Seguro³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinaseassociated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKIassociated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.

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“…A doença se estendeu além das áreas rurais e tornou-se uma das causas de epidemias em comunidades urbanas dos países em desenvolvimento (Pappas et al 2008). Nesses países, como…”

Section: Introductionunclassified

“…A doença se estendeu além das áreas rurais e tornou-se uma das causas de epidemias em comunidades urbanas dos países em desenvolvimento (Pappas et al 2008). Nesses países, como no caso do Brasil, a sua ocorrência está relacionada ao acelerado e desordenado processo de expansão urbana, onde grande parte da população passou a habitar áreas da periferia, sem o mínimo de condições de infraestrutura e saneamento, facilitando a manutenção de agentes patogênicos nocivos à saúde animal e humana.…”

Section: Introductionunclassified

Análise espacial do risco de leptospirose canina na Vila Pantanal, Curitiba, Paraná

et al. 2013

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Pesq. Vet. Bras. 33(1): 74-79, janeiro 2013 74 RESUMO.-A leptospirose é uma grave zoonose associada às áreas de baixa renda dos centros urbanos. Embora roedores urbanos sejam considerados como principal reservatório para a leptospirose, o cão também pode desenvolver a doença e se tornar carreador assintomático. O objetivo do presente trabalho foi utilizar a metodologia estatística baseada na teoria de processos pontuais espaciais, buscando identificar a forma como se distribuem os cães sororreagentes para a leptospirose e seus determinantes de risco em uma vila na cidade de Curitiba. A análise do modelo possibilitou identificar as regiões de sobre-risco, Leptospirosis is a serious zoonotic disease associated to low income areas of urban settings. Although rodents are considered the main reservoir for urban leptospirosis, dogs may also develop the disease and become asymptomatic carriers. The objective of this study was to apply a statistical method based on the spatial point processes theory for canine leptospirosis to identify how seroreagents dogs are spatially distributed and their risk determinants in a village of Curitiba city. The model analysis allowed the identification of over-risk regions, where seropositivity risk for canine leptospirosis was significantly higher, revealing that not just one, but the combination of animal, owner and environment factors influenced the disease risk within areas with greater spatial effect. Analysis of results clearly identified the highest risk areas in the Pantanal Village, allowing the establishment of more specific preventive actions and focused on risk areas as priority for public health surveillance. onde o risco de soropositividade canina à leptospirose é significativamente maior. A relação significativa do efeito espacial no desenvolvimento da doença, além das variáveis estudadas, revela que não apenas um, mas a ação conjunta dos fatores relacionados ao animal, ao proprietário e ao ambiente influencia o risco maior da doença nos locais de maior efeito espacial. O resultado da análise indica claramente os territórios em maior risco na região da Vila Pantanal, possibilitando o planejamento de ações mais específicas e dirigidas a essas áreas em um contexto de vigilância da saúde. INTRODUÇÃOA leptospirose é uma zoonose reconhecida como um importante problema de saúde pública mundial. A doença se estendeu além das áreas rurais e tornou-se uma das causas de epidemias em comunidades urbanas dos países em desenvolvimento (Pappas et al. 2008). Nesses países, como

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The globalization of leptospirosis: worldwide incidence trends

Abstract: Leptospirosis is a re-emerging zoonosis of global importance and unique environmental and social correlations. Attempts at global co-ordination and recognition of the true burden of an infectious disease with significant mortality should be encouraged.

Cited by 454 publications

References 34 publications

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines

Endothelial Glycocalyx Damage is Associated with Leptospirosis Acute Kidney Injury

Análise espacial do risco de leptospirose canina na Vila Pantanal, Curitiba, Paraná

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