The global scientific research response to the public health emergency of Zika virus infection

Oliveira, Juliane F.; Pescarini, Júlia Moreira; Rodrigues, Moreno S.; Almeida, Bethânia de Araújo; Henriques, Cláudio Maierovitch Pessanha; Gouveia, Fábio Castro; Rabello, Elaine Teixeira; Matta, Gustavo Corrêa; Barreto, Maurício L.; Sampaio, Ricardo Barros

doi:10.1371/journal.pone.0229790

Cited by 19 publications

(24 citation statements)

References 20 publications

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“…The short-term effect of research efforts of earlier CoV research and the strengthening of international networking could also be shown with regard to another emerging virus epidemic that occurred in South America in 2015: the Zika virus infection. The publication patterns corresponded to those reported here and showed an unsustainable short-term effect of national and international efforts [ 30 ]. This similar publication pattern was reinforced by the enormous research incentives of short-term funding and public recognition due to the acute threat.…”

Section: Discussionsupporting

confidence: 83%

Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future

Klingelhöfer¹,

Braun²,

Brüggmann³

et al. 2020

Journal of Global Health

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Background The currently prevailing global threat of COVID-19 caused the publication numbers on coronaviruses to explode. The awareness of the scientific and public community is enormous. But what about the sense of all these undertakings and what can be learned about the future for a better understanding? These questions were answered with established bibliometric analyses of the time until the avalanche of publications unfolded. Methods Chronological, geographical aspects of publication output on coronavirus were also evaluated under the influence of epidemiological and socio-economic parameters. Results The trend in publication and citation numbers shows the strong influence of the past pandemics SARS and MERS with an untypical decline afterward. Research is becoming increasingly multidisciplinary over time. The USA and China, as the countries with the highest number of publications, are being displaced by other countries in the consideration of socio-economic and epidemiological aspects, which shows the effect of regional interest in corona research. A significant correlation was found between the number of SARS cases per country and related publications, while no correlation was found for MERS cases and articles. Conclusions The results underline the need for sustainable and forward-looking approaches that should not end with the containment of COVID-19.

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Section: Discussionsupporting

confidence: 83%

Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future

Klingelhöfer¹,

Braun²,

Brüggmann³

et al. 2020

Journal of Global Health

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“…Our results highlighted the importance of gathering public interest in global health issues, and how public interest can act as a powerful catalyzer to trigger the research eld (30,31). Likewise, we found that the efforts to overcome the global emergency caused by the ZIKV outbreak in the Americas led to globalization in the research eld (32).…”

Section: Discussionsupporting

confidence: 59%

The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis

Gwon

Evander

2021

Preprint

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Background Zika virus (ZIKV) is a mosquito-borne disease discovered in 1947, but with no reports of serious disease for almost 60 years. The first large ZIKV outbreak was reported from Yap island in 2007, then in 2015, the emergence of ZIKV in the Americas highlighted clinical manifestations such as microcephaly and Guillain‐Barré syndrome. On February 1, 2016, WHO declared a Public Health Emergency of International Concern due to the magnitude of the outbreak, which then officially ended in November 2016. Methods Ever since the Brazilian authority released the first report of autochthonous transmission of ZIKV in 2015, it became the object of interdisciplinary investigation and global research collaboration. To follow and understand the trend of ZIKV research, we performed a systematic review and meta-analysis of ZIKV publications during 2014-2018, by using the scientific database Scopus.Results We found that the number of ZIKV related publications increased in 2016, 2017, and 2018 (39.2, 56.5, and 58.5 times, respectively) compared to an average number of publications (23.5) in 2014-2015. During the five years, there was not only an increment of publication numbers but also the area of research was expanded. In 2014-2015, the majority in the research area was epidemiological research with the aims to report the consequence of the ZIKV outbreak, and the trend was shifted to the development of diagnostic methods, antiviral treatment, and vaccine in the following three years. In addition, the number of countries involved in ZIKV research increased from 11 and 13 in 2014-2015 to 59, 67, and 66 in 2016-2018, showing that ZIKV research was changed from a low-level stage to active and globalized in the coming five years.Conclusions Our results highlight the importance of gathering public interest when the world is facing the phase of global health alert, and how it can drive the research field from inactive to active. However, despite this enormous progress in ongoing ZIKV research, many questions are yet to be answered and should be addressed to accelerate the development of effective ZIKV countermeasures. Nevertheless, our systematic review and meta-analysis emphasized the importance of a worldwide multidisciplinary effort to combat outbreaks or unknown infectious disease threats in the future.

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“…In 1947, in the Zika forest of Uganda, ZIKV was primarily identi ed in a sentinel rhesus monkey and was rst detected in humans in 1952. In 2014, the virus quickly spread into the Americas and in 2016, the World Health Organization (WHO) declared ZIKV epidemic as a public health emergency [17,[19][20][21]. Considerable scienti c efforts resulted in many candidate vaccines that are currently undergoing further clinical development.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Bioactivity of Resveratrol Against Zika Virus Infection in Human Retinal Pigment Epithelial Cells

Russo

Torti

Márquez

et al. 2021

Preprint

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Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Zika virus (ZIKV) is an arbovirus of the Flaviviridae family for which there is no approved treatment or vaccine, and which has become a major global health threat. Within the broad spectrum of ophthalmological manifestations after infection, retinal pigment epithelial cells (RPE) type is one of the most permissive and susceptible to the virus. This work explored the protective effects of RES on ZIKV-infected human RPE cells. RES treatment resulted in a significant reduction of infectious viral titer in infected male ARPE-19 and female hTERT-RPE1 cells. This protection was positively influenced by the action of RES on mitochondrial dynamics, restoring the ZIKV induced fragmentation of mitochondrial network to conditions similar to those of uninfected control cultures. Also, docking studies showed that RES has a high affinity for two enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis and viral polymerase. In conclusion, our findings indicated that RES could be considered as an antiviral agent to treat ZIKV-induced ocular abnormalities.

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The global scientific research response to the public health emergency of Zika virus infection

Cited by 19 publications

References 20 publications

Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future

Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future

The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis

Antiviral Bioactivity of Resveratrol Against Zika Virus Infection in Human Retinal Pigment Epithelial Cells

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