The global, regional and national burden of stomach cancer and its attributable risk factors from 1990 to 2019

Abstract

We aimed to estimate the incidence, mortality, and disability-adjusted life-years (DALYs) of stomach cancer at the global, regional, and national levels. Stomach cancer resulted in 1.3 million (1.2–1.4 million) incident cases, 9.5 hundred thousand (8.7–10.4 hundred thousand) deaths, and 22.2 million (20.3–24.1 million) DALYs in 2019. The age-standardized incidence rate, death rate and DALY rate were 15.6 (14.1–17.2), 11.9 (10.8–12.8), and 268.4 (245.5–290.6) per 100,000 person-years, respectively. Between 1990 and 2019, the global age-standardized incidence rate, death rate, and DALY rate decreased by − 30.5% (− 36.7 to − 22.9), − 41.9% (− 47.2 to − 36.3), and − 45.6% (− 50.8 to − 39.8), respectively. In 2019, most of the global numbers of incidence, death and DALYs were higher among males than females. A considerable burden of stomach cancer was attributable to smoking and a high-sodium diet. Although the global age-standardized incidence and death rates have decreased, continued growth in absolute numbers in some regions, especially in East Asia, poses a major global public health challenge. To address this, public health responses should be tailored to fit each country’s unique situation. Primary and secondary prevention strategies with increased effectiveness are required to reduce the incidence and mortality of stomach cancer, particularly in populations with a high disease burden.

The Global, Regional, National Burden of Cutaneous Squamous Cell Carcinoma (1990–2019) and Predictions to 2035

“…In this study, data on the disease burden of cSCC were obtained through an online query tool from the website of the Institute for Health Metrics and Evaluation (IHME) (https://ghdx.healthdata.org/). Te general methodology of GBD 2019 developed by IHME has been explained in the previous publications [7][8][9][10][11]. Tis study followed the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) reporting guideline for cross-section studies [12].…”

Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer

“…With the development of economy and living standards, the prevalence of Helicobacter pylori ( H. pylori ) which is the key risk factor of non-cardia gastric cancer has decreased ( 7 ). Despite a consistent decrease in the rates of morbidity and mortality, more cases of gastric cancer can be seen in the future because of ageing populations ( 8 ). The disease’s late diagnosis and high mortality rate reveal a lack of knowledge regarding its etiology and pathology, as well as the absence of efficient treatments.…”

Role of Adjuvant Radiotherapy in Gastric Cancer

“…Gastric cancer (GC) ranks fifth in terms of incidence and fourth in terms of mortality worldwide [ 1 ] and remains the fourth most commonly diagnosed cancer in Korea [ 2 ]. Fortunately, the incidence of GC is continuously declining, and the age-standardized incidence rate also decreased by 30.5% between 1990 and 2019 worldwide [ 3 ]. In a recent study on the epidemiology of GC in Korea, the age-standardized incidence rate per 100,000 population significantly decreased from 34.0 in 2011 to 29.6 in 2019 [ 4 ].…”