The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis

Salari, Nader; Ghasemi, Hooman; Fatahian, Reza; Mansouri, Kamran; Dokaneheifard, Sadat; Shiri, Mohammad hossain; Hemmati, Mahvan; Mohammadi, Masoud

doi:10.1186/s40001-023-01011-y

Cited by 29 publications

(22 citation statements)

References 86 publications

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“…This patient cohort with newly diagnosed glioma was comprised of 121 (65.1%) males and 65 (34.9%) females, as shown in Figure 3. The χ 2 value was estimated to compare the expected ratios with the observed ratios separately for sex groups, age groups, tumor grade, radiotherapy, and chemotherapy across different tumor grades. Both men and women demonstrated an increase in mortality with an increasing degree of glioma (grade IV) (Figure 4A).…”

Section: Resultsmentioning

confidence: 99%

“…Descriptive statistics were employed to summarize continuous measures, including the number of observed values, median, standard deviation, median, and range. To examine the differences between subgroups, categorized data were compared using the Chi-square (χ 2 ) test. Furthermore, we employed the two-tailed Student’s t-test to analyze the age distribution comparison.…”

Section: Methodsmentioning

confidence: 99%

“…Glioblastoma (GBM) is a glioma of the highest grade with, has a very dismal prognosis. Gliomas can develop at any age, but are most common in older adults 1, 2 . Patients with GBM under 70 years of age showed a median lifespan of around 14.6 months, even with the best current standard of treatment, which includes adjuvant chemotherapy with temozolomide (TMZ) and chemoradiotherapy after tumor excision.…”

Section: Introductionmentioning

confidence: 99%

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Overview of prognostic factors in adult glioma; a 10-year experience at a single institution

Behrooz,

Ramandi,

Latifi-Navid

et al. 2024

Preprint

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Objective: The most prevalent central nervous system (CNS) neoplasm arising from glial cells is glioma, which diffusely invades brain tissue. Among gliomas, Glioblastoma (GBM) is a glioma of the highest grade and associated with a grim prognosis, with a median overall survival of 15 months with and 3-4 months without therapy. We examined how clinical variables and molecular profiles may have affected overall survival (OS) at Sina Hospital in Tehran over the past ten years. Methods: A retrospective study was conducted at Sina Hospital in Tehran, Iran, and examined patients older or equal 11 years with confirmed glioma diagnoses between 2012 and 2020. We evaluated the correlation between OS in GBM patients and sociodemographic as well as clinical factors, including age, gender, extent of tumor resection, tumor location, chemo/radiotherapy, and molecular profiling based on IDH1, MGMT, TERT, and EGFR status. Kaplan-Meier and multivariate Cox regression models were used to assess patient survival. Results: Following a comprehensive evaluation of medical records, 186 patients were enrolled in the study. The median OS was 20 months, with a 2-year survival rate of 62.5%. Among the 132 patients with available IDH measurements, 105 (79.5%) exhibited IDH1 wild-type tumors. Of the 132 patients with assessed MGMT methylation, 94 (71.2%) had MGMT methylated tumors. TERT promoter methylation was detected in 112 out of 132 cases (84.8%), while no methylation was observed in 20 cases (15.2%). Analyses using multivariable models revealed that age at histological grade (P < 0.0001), adjuvant radiotherapy (P < 0.014), IDH1 status (P < 0.026), and TERT promoter status (P < 0.030) were independently associated with OS. Conclusion: The findings of this study demonstrate that patients with higher tumor histological grades who had received adjuvant radiotherapy, exhibited IDH1 mutations, or presented with TERT promoter mutations, experienced improved OS. The median survival time was 20 months, with 15.6% and 46.9% of patients surviving at 12 and 24 months, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Overview of prognostic factors in adult glioma; a 10-year experience at a single institution

Behrooz,

Ramandi,

Latifi-Navid

et al. 2024

Preprint

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“…Glioma symptoms primarily result from tumor mass effects. High-grade gliomas often cause acute increases in intracranial pressure, disturbances of consciousness, unstable vital signs and brain herniation [25] . The severity of these symptoms tends to correlate with the tumor grade.…”

Section: The Impact Of Combined Intracavitary Ecg-guided Picc Tip Pos...mentioning

confidence: 99%

Enhancing Tube Feeding Method for Neurosurgery: The Application of Improved PICC Technique

Wu¹,

Qiu²,

Wang³

et al. 2023

Preprint

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Background and purpose Peripherally inserted central catheter (PICC) used in neurosurgical patients require changes in patients' head positions. However, such changes can worsen pressure on the brain tissue, lead to sudden acute brain herniation and respiratory arrest, resulting in a higher chance of patient death. This paper addresses the aforementioned problems by introducing a new PICC catheterization method. Method In a retrospective study, the records of patients with PICC from April 2020 to April 2023 were reviewed, and they were divided into three groups based on the methods employed. The first group as the conventional group, involved changing patients’ body positions during catheterization. The second group, as the intracavitary electrocardiographic (IECG) group, utilized intracavitary electrocardiographic monitoring and involved changing patients’ body positions during catheterization. The third group as the intracavitary electrocardiographic with improved body positioning (IECG-IBP) group, catheterization was performed with guidance from intracavitary electrocardiographs and without changing the patients’ body positions. The ECG changes among patients undergoing different catheter delivery methods were then compared, as well as the rate of catheter tip misplacement. Result The study encompassed a total of 354 cases. Our findings reveal distinct P wave amplitude percentages among the groups: 0% in the conventional group, 88.46% in the IECG group, and 91.78% in the IECG-IBP group. Furthermore, the following catheter tip misplacement rates were recorded: 11.54% for the conventional group, 5.39% for the IECG group, and 5.47% for the IECG-IBP group. Significantly notable differences were observed in these two key indicators between the conventional group and the IECG-IBP group. Notably, the IECG-IBP group demonstrated a more favorable outcome compared to the IECG group. Conclusion The study evidence that the PICC catheterization method, incorporating intracavitary electrocardiographic positioning technology and improved body positioning effectively mitigates the risk of induced sudden acute brain herniation and death in patients.

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“…Brain tumors are the second leading cause of death in children and are a signi cant health challenge worldwide [1][2][3][4][5]. Depending on tumor type, size, location and patient age, radiation therapy is often used to improve local control and survival [6][7][8][9][10][11]. However, brain radiation can lead to cognitive declines similar to those observed in neurodegenerative patients [12,13].…”

Section: Introductionmentioning

confidence: 99%

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

Grosshans,

Thomas,

Zhang

et al. 2024

Preprint

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Injury responses in terminally differentiated cells such as neurons is tightly regulated by pathways aiding homeostatic maintenance. Cancer patients subjected to neuronal injury in brain radiation experience cognitive declines similar to those seen in primary neurodegenerative diseases. Numerous studies have investigated the effect of radiation in proliferating cells of the brain, yet the impact in differentiated, post-mitotic neurons, especially the structural and functional alterations remain largely elusive. We identified that microtubule-associated tau is a critical player in neuronal injury response via compartmentalized functions in both repair-centric and synaptic regulatory pathways. Ionizing radiation-induced injury acutely induces increase in phosphorylated tau in the nucleus and directly interacts with histone 2AX (H2AX), a DNA damage repair (DDR) marker. Loss of tau significantly reduced H2AX after irradiation, indicating that tau may play an important role in neuronal DDR response. We also observed that loss of tau increases eukaryotic elongation factor levels after irradiation, the latter being a positive regulator of protein translation. This cascades into a significant increase in synaptic proteins, resulting in disrupted homeostasis. Consequently, novel object recognition test showed decrease in learning and memory in tau-knockout mice after irradiation, and electroencephalographic activity showed increase in delta and theta band oscillations, often seen in dementia patients. Our findings demonstrate tau’s previously undefined, multifunctional role in acute responses to injury, ranging from DDR response in the nucleus to synaptic function within a neuron. Such knowledge is vital to develop therapeutic strategies targeting neuronal injury in cognitive decline for at risk and vulnerable populations.

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The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis

Cited by 29 publications

References 86 publications

Overview of prognostic factors in adult glioma; a 10-year experience at a single institution

Overview of prognostic factors in adult glioma; a 10-year experience at a single institution

Enhancing Tube Feeding Method for Neurosurgery: The Application of Improved PICC Technique

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

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