The global prevalence of major depressive disorder (MDD) among the elderly: A systematic review and meta-analysis

Abdoli, Nasrin; Salari, Nader; Darvishi, Niloofar; Jafarpour, Sima; Solaymani, Mina; Mohammadi, Masoud; Shohaimi, Shamarina

doi:10.1016/j.neubiorev.2021.10.041

Cited by 173 publications

(110 citation statements)

References 42 publications

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“…In the presented study, remaining in a romantic relationship turned out to be a protective factor against the onset of depression symptoms (severe depression measured with the GHQ-D subscale was lower in students involved in any partnership (informal or formal) than in single students). This result is consistent with the reports of other authors [32,33] and the views emphasizing the role of the lack of social support in the etiology of depressive disorders [29,34].…”

Section: Discussionsupporting

confidence: 93%

Mental Health of PhD Students at Polish Universities—Before the COVID-19 Outbreak

Kowalczyk¹,

Karbownik

Kowalczyk

et al. 2021

IJERPH

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Background: A group particularly exposed to the occurrence of disorders in the sphere of the psyche are young people with a newly developing personality structure and a sense of identity. In the available literature there are few reports describing the mental health of doctoral students—a group that is affected by a particular group of stressors. The aim of the research was to assess the mental health of PhD students at Polish universities. Material and Methods: The Polish adaptation of the GHQ Questionnaire-28, developed by David Goldberg et al. was used in the research. PhD students from all universities associated in the National Representation of Doctoral Students were invited to take part in the research. A total of 576 completed questionnaires were received. Results: It was found that depression is statistically more frequent in doctoral students who are not in any relationship with another person; anxiety/insomnia is more common in women than men and less frequently in doctoral students of general than in technical universities. Conclusions: (1) More than half of the surveyed students complain about the deterioration of mental health. The most commonly reported symptom groups are anxiety and insomnia, followed by social dysfunctions and somatic symptoms. (2) Depression is statistically more common in people who are not in any relationship with another person and anxiety and insomnia are statistically more common in women than in men and statistically less frequent in doctoral students of general universities than technical universities. (3) In view of the presented results, educating young adults in the field of self-awareness in the field of mental health seems to be particularly important.

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Section: Discussionsupporting

confidence: 93%

Mental Health of PhD Students at Polish Universities—Before the COVID-19 Outbreak

Kowalczyk¹,

Karbownik

Kowalczyk

et al. 2021

IJERPH

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“…Depression is the most prevalent mental health issue among older adults that can intervene in healthy aging [ 1 ]. A recent meta-analysis found a global prevalence of depression in older adults to be 13.3% [ 2 ], while another estimated the prevalence at 28.4% [ 3 ]. Depression has a destructive effect on quality of life, physical and psychological health and is a significant obstacle to healthy aging [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Unmet Healthcare Needs Predict Depression Symptoms among Older Adults

Eimontas

Gegieckaitė

Zamalijeva

et al. 2022

IJERPH

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Risk factors for depression in older adults include significant interpersonal losses, increasing social isolation, and deteriorating physical abilities and health that require healthcare. The effects of unmet healthcare needs on depression in older adults are understudied. This study aimed to analyze the association between unmet healthcare needs and symptoms of depression, sleep, and antidepressant medication while controlling for other significant factors among older adults. For this study, we used a multinational database from The Survey of Health, Ageing and Retirement in Europe (SHARE), containing data of individuals aged 50 and older. The final sample used in this research consisted of 39,484 individuals from 50 to 100 years (mean − 71.15, SD ± 9.19), 42.0 percent of whom were male. Three path models exploring relationships between symptoms of depression at an older age and unmet healthcare needs were produced and had a good model fit. We found that unmet healthcare needs were directly related to depression, activity limitations were related to depression directly and through unmet healthcare needs, whereas financial situation mostly indirectly through unmet healthcare needs. We discuss how depression itself could increase unmet healthcare needs.

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“…Late-life depression (LLD) can be defined as major depressive disorder that occurs for 60 years of age or older ( 1 , 2 ). The global prevalence of LLD is 13.3%, which is significantly higher than that of depression in younger age ( 3 ). The response rate of treatment for late-life depression (LLD) is only 25–60% ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Prediction of Antidepressant Efficacy by Cognitive Function in First-Episode Late-Life Depression: A Pilot Study

et al. 2022

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The response rate of treatment for late-life depression (LLD) is only 25–60%. The cognitive impairment associated with LLD often affects the effectiveness of antidepressants and may has the potential ability to predict response. This study seeks a biomarker for baseline cognitive function to predict efficacy of antidepressants. Sixty patients diagnosed with LLD received escitalopram or sertraline treatment for 8 weeks. Clinical symptom was measured using Hamilton Depression Rating Scale-17 (HAMD-17) and cognitive function was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Trail Making Test (TMT) before and after 8-week treatment. Patients were divided into treatment effective group (TE) and treatment ineffective group (TI) according to reduction rate in scores of HAMD-17 after treatment. Thirty-eight matched healthy controls (HC) were assessed using RBANS and TMT. There was significant decrease of score of RBANS and increase of score of TMT in patients with LLD compared with HC. Regression analysis revealed that change in HAMD-17 score was significantly positively associated with baseline score of picture naming, figure copy, digit span, and delayed memory. The preliminary findings suggested that working memory, attention, visuospatial, language function, and delayed memory should be examined further as a means of providing the useful objective biomarkers of treatment response.Clinical Trials Registration[www.ClinicalTrials.gov], identifier [ChiCTR2100042370].

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The global prevalence of major depressive disorder (MDD) among the elderly: A systematic review and meta-analysis

Cited by 173 publications

References 42 publications

Mental Health of PhD Students at Polish Universities—Before the COVID-19 Outbreak

Mental Health of PhD Students at Polish Universities—Before the COVID-19 Outbreak

Unmet Healthcare Needs Predict Depression Symptoms among Older Adults

Prediction of Antidepressant Efficacy by Cognitive Function in First-Episode Late-Life Depression: A Pilot Study

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