The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

Stockdale, Alexander; Kreuels, Benno; Henrion, Marc; Giorgi, Emanuele; Kyomuhangi, Irene; Martel, Catherine de; Hutin, Yvan; Geretti, Anna María

doi:10.1016/j.jhep.2020.04.008

Cited by 393 publications

(552 citation statements)

References 24 publications

(43 reference statements)

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“…Approximately 12 million persons are infected with hepatitis D worldwide [1]. The incidence of hepatitis D virus (HDV) remains high in Asia and is a significant cause of morbidity [2].…”

Section: Introductionmentioning

confidence: 99%

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Abbas

Qadeer

Mandviwalla

et al. 2020

Cureus

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Background Current literature on the prevalence and characteristics of hepatitis D virus (HDV) infection in young adults is limited. This study aims to determine the disease characteristics and severity in young adults. Methods The case records of HDV RNA positive patients of age 18-25 years were analyzed. Results Out of 119 patients, 105 (88%) patients were male. HBV-DNA was detectable in 83 (70%). Hepatitis B eantigen (HBeAg) was non-reactive in 99 (83%). Cirrhosis was identified in 45 (37.8%) individuals; nine (7.5%) were classified as Child class B or Child class C. Twenty-four (20.2%) had a Model For End-Stage Liver Disease (MELD) score of ≥10, out of these 16 had a score of 15 or more. The risk of decompensation was calculated according to the Baseline-event-anticipation (BEA) score; eight (6.7%) patients were at BEA-A (mild risk), 105 (88.2%) were at BEA-B (moderate risk), and six (5.0%) were at BEA-C (severe risk). Notable findings in patients with cirrhosis included splenomegaly, low total leucocyte counts, low platelets, high bilirubin, elevated aspartate aminotransferase, gamma-glutamyl transferase and international normalization ratio, low albumin, high AST to Platelet Ratio Index (APRI), and high BEA score. The splenic size, platelet count, and albumin levels were independently associated with cirrhosis (p < 0.001, <0.001, and 0.003). A model using a combination of platelet count, albumin, and spleen size was developed to accurately predict cirrhosis in this cohort. It had an area under the receiver operating characteristics (AUROC) of 0.935. Conclusions HDV-infected young adults, age 18-25 years, were at moderate to severe risk of disease progression. About one-third of patients had already developed cirrhosis indicating the aggressive nature of the disease.

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“…Approximately 12 million persons are infected with hepatitis D worldwide [1]. The incidence of hepatitis D virus (HDV) remains high in Asia and is a significant cause of morbidity [2].…”

Section: Introductionmentioning

confidence: 99%

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Abbas

Qadeer

Mandviwalla

et al. 2020

Cureus

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“…In this way, the postulates were assigned a rank. In the first group of most important priorities (i.e., high number of credits [11][12][13][14][15][16][17][18]), four postulates were included. In the second group of moderate priorities (4-7 credits), there were seven postulates.…”

Section: Methodsmentioning

confidence: 99%

Bridging the Gap between Theory, Practice, and Policy: A Decision-making Process Based on Public Health Evidence Feasible in Multistage Research on Biology Risk Factors in Poland

Kuczerowska¹,

Lahiri²,

Gajda³

2020

Preprint

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Stakeholder input into the decision-making process when developing public health programs and policies is crucial. This article presents an innovative approach, involving online participation with a wide group of stakeholders located in different geographic locations, for policy consensus by research methodology. The results of the project have been used to propose assumptions regarding a strategy for preventing blood-borne diseases in Poland. The research was conducted iteratively using a multi-stage qualitative methodology to explore risk assessment involving blood-borne infections. The final output of the entire project is a list of key problems/challenges and solutions associated with medical and nonmedical services that are connected to the breakage of tissue continuity. Qualitative research is rare in risk assessment as priority is usually given to statistical data and end-points (quantitative studies ). Statistical data on health risk allows to assess the health implications, while the methodology applied also allowed diagnosis of the processes leading to these effects. In addition to policy preparation for blood-borne illnesses, the methodology employed in the study can also be used to successfully explore other areas of public health policy decisions.

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“…The clinical manifestations of HDV infection in HBV co-infected individuals are typically more severe with a higher incidence of HCC and increased liver-related and overall mortality. HDV infection is an understudied disease and as such, epidemiological data relating to its global prevalence varies widely, with recent studies estimating that somewhere between 12 and 72 million people have experienced the virus [24,25]. HDV replication occurs in the nucleus of hepatocytes, and it has been proposed that it replicates using a double rolling circle mechanism.…”

Section: Epidemiology and Virologymentioning

confidence: 99%

Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Healy

Pasetto

Sobkowiak

et al. 2020

Cells

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Chronic infection with viral hepatitis is a major risk factor for liver injury and hepatocellular carcinoma (HCC). One major contributing factor to the chronicity is the dysfunction of virus-specific T cell immunity. T cells engineered to express virus-specific T cell receptors (TCRs) may be a therapeutic option to improve host antiviral responses and have demonstrated clinical success against virus-associated tumours. This review aims to give an overview of TCRs identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field. TCR isolation pipelines, liver homing signals, cell type options, as well as safety considerations will be discussed herein.

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The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

Cited by 393 publications

References 24 publications

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

The Severity of Hepatitis D in Young Adults of Age 18-25 Years

Bridging the Gap between Theory, Practice, and Policy: A Decision-making Process Based on Public Health Evidence Feasible in Multistage Research on Biology Risk Factors in Poland

Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

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