The Global Posttranscriptional Regulator RsmA Modulates Production of Virulence Determinants and N -Acylhomoserine Lactones in Pseudomonas aeruginosa

Abstract

2A: "(pME3849)" and "(pME6001)" should be deleted from all three graphs. The data are for the plasmid-free PAO1 and PAZH13 strains.

Post-transcriptional global regulation by CsrA in bacteria

“…It regulates multiple unrelated pathways such as central carbon metabolism, motility and biofilm formation, virulence and pathogenesis, quorum sensing and oxidative stress response (Fig. 2), although some subtle differences exist depending on the bacterial species studied [44,52,58,59,62,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81]. Several homologues have been identified in other bacterial species [82].…”

“…In several species including Vibrio sp. and Pseudomonas sp., CsrA negatively regulates the production of AHL, although the underlying molecular mechanism is still unknown [79,101]. In E. carotovora subsp.…”

Pseudomonas aeruginosa and Burkholderia cepacia in cystic fibrosis: genome evolution, interactions and adaptation

“…Thus, the two QS systems of P. aeruginosa are hierarchically arranged with the las system being on top of the signalling cascade (Latifi et al, 1996). A number of regulators, including Vfr (Albus et al, 1997), GacA (Reimmann et al, 1997), RsaL (De Kievit et al, 1999), MvaT (Diggle et al, 2002), RsmA (Pessi et al, 2001), DksA (Jude et al, 2003), QscR (Chugani et al, 2001), and VqsR (Juhas et al, 2004), have been identified that are involved in modulating the QS circuitry. An additional signal molecule, the P. aeruginosa quinolone signal, adds a further level of complexity, as it provides a link between the las and rhl systems (Pesci et al, 1999) by modulating expression of rhlRI and lasRI (McKnight et al, 2000;Diggle et al, 2003).…”

Dialogues of root-colonizing biocontrol pseudomonads

“…In strains of P. aeruginosa, the conserved GacS/ GacA system directs the synthesis of two small RNAs, designated RsmY and RsmZ, which antagonize one CsrA homolog, named RsmA (Reimmann et al 1997;Pessi et al 2001;Heurlier et al 2004;Kay et al 2006) (Fig. 2b).…”

“…2a). In P. aeruginosa, target genes include hcnA and the phz genes (Reimmann et al 1997;Pessi et al 2001) (Fig. 2b).…”