The global pipeline of GM crops out to 2020

Parisi, Claudia; Tillie, Pascal; Rodríguez‐Cerezo, Emilio

doi:10.1038/nbt.3449

Cited by 123 publications

(65 citation statements)

References 19 publications

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“…However, commercialization of these traits is currently minor. Agricultural genetically modified (GM) crops are dominated by plants engineered to tolerate application of a herbicide or/and to produce their own insecticides2. A total of 180 million hectares of GM crops are currently cultivated worldwide on around 1.5 billion hectares constituting approximately 10% of global arable land3.…”

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confidence: 99%

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

Mesnage

Agapito-Tenfen

Vilperte

et al. 2016

Sci Rep

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Glyphosate tolerant genetically modified (GM) maize NK603 was assessed as ‘substantially equivalent’ to its isogenic counterpart by a nutrient composition analysis in order to be granted market approval. We have applied contemporary in depth molecular profiling methods of NK603 maize kernels (sprayed or unsprayed with Roundup) and the isogenic corn to reassess its substantial equivalence status. Proteome profiles of the maize kernels revealed alterations in the levels of enzymes of glycolysis and TCA cycle pathways, which were reflective of an imbalance in energy metabolism. Changes in proteins and metabolites of glutathione metabolism were indicative of increased oxidative stress. The most pronounced metabolome differences between NK603 and its isogenic counterpart consisted of an increase in polyamines including N-acetyl-cadaverine (2.9-fold), N-acetylputrescine (1.8-fold), putrescine (2.7-fold) and cadaverine (28-fold), which depending on context can be either protective or a cause of toxicity. Our molecular profiling results show that NK603 and its isogenic control are not substantially equivalent.

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mentioning

confidence: 99%

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

Mesnage

Agapito-Tenfen

Vilperte

et al. 2016

Sci Rep

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“…Nevertheless, annual surveys from ISAAA (2015) indicate widespread adoption of a limited number of modified crops species (mostly oilseed rape, soya and maize) and a limited number of traits (mostly herbicide tolerance and insect resistance). The research pipeline continues to offer novel crop applications (Parisi et al 2016), although their penetration into practical use has been slow to date. In contrast, there are no genetically modified (GM) food animals being sold for food at the time of writing, to my knowledge.…”

Section: Introductionmentioning

confidence: 99%

Genome edited animals: Learning from GM crops?

Bruce

2017

Transgenic Res

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Genome editing of livestock is poised to become commercial reality, yet questions remain as to appropriate regulation, potential impact on the industry sector and public acceptability of products. This paper looks at how genome editing of livestock has attempted to learn some of the lessons from commercialisation of GM crops, and takes a systemic approach to explore some of the complexity and ambiguity in incorporating genome edited animals in a food production system. Current applications of genome editing are considered, viewed from the perspective of past technological applications. The question of what is genome editing, and can it be considered natural is examined. The implications of regulation on development of different sectors of livestock production systems are studied, with a particular focus on the veterinary sector. From an EU perspective, regulation of genome edited animals, although not necessarily the same as for GM crops, is advocated from a number of different perspectives. This paper aims to open up new avenues of research on genome edited animals, extending from the current primary focus on science and regulation, to engage with a wider-range of food system actors.

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“…Over the years the main targets were food and feed along with improvements in herbicide and pesticide tolerance. Recently, scientists have also focused on improvement and enhancement of quality attributes for industry (Noman et al, 2016b, 2017; Parisi et al, 2016). The prime benefit in adopting GE is that gene from other species gene pool can be introduced in ornamental plants (Li and Pei, 2006; Chandler and Brugliera, 2011).…”

Section: Introductionmentioning

confidence: 99%

Biotechnological Advancements for Improving Floral Attributes in Ornamental Plants

et al. 2017

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Developing new ornamental cultivars with improved floral attributes is a major goal in floriculture. Biotechnological approach together with classical breeding methods has been used to modify floral color, appearance as well as for increasing disease resistance. Transgenic strategies possess immense potential to produce novel flower phenotypes that are not found in nature. Adoption of Genetic engineering has supported the idea of floral trait modification. Ornamental plant attributes like floral color, fragrance, disease resistance, and vase life can be improved by means of genetic manipulation. Therefore, we witness transgenic plant varieties of high aesthetic and commercial value. This review focuses on biotechnological advancements in manipulating key floral traits that contribute in development of diverse ornamental plant lines. Data clearly reveals that regulation of biosynthetic pathways related to characteristics like pigment production, flower morphology and fragrance is both possible and predictable. In spite of their great significance, small number of genetically engineered varieties of ornamental plants has been field tested. Today, novel flower colors production is regarded as chief commercial benefit obtained from transgenic plants. But certain other floral traits are much more important and have high commercial potential. Other than achievements such as novel architecture, modified flower color, etc., very few reports are available regarding successful transformation of other valuable horticultural characteristics. Our review also summarized biotechnological efforts related to enhancement of fragrance and induction of early flowering along with changes in floral anatomy and morphology.

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The global pipeline of GM crops out to 2020

Cited by 123 publications

References 19 publications

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

Genome edited animals: Learning from GM crops?

Biotechnological Advancements for Improving Floral Attributes in Ornamental Plants

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