The Global Neurological Burden of Tuberculosis

Thakur, Kiran T.; Das, Mitashee; Dooley, Kelly E.; Gupta, Amita

doi:10.1055/s-0038-1651500

Cited by 38 publications

(9 citation statements)

References 70 publications

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“…Spinal tuberculosis is one of the most common extrapulmonary tuberculosis, and approximately accounts for half of bone and joint tuberculosis, which is harmful to human body and may cause vertebral collapse, kyphosis deformity and paraplegia. In recent years, with the global resurgence of tuberculosis, the incidence of spinal tuberculosis in China has been increasing year by year [1, 2]. The incidence of mid-thoracic (T5–9) spinal tuberculosis is second to that of thoracolumbar and lumbar tuberculosis, and the most vulnerable populations include young people and middle-aged people.…”

Section: Introductionmentioning

confidence: 99%

Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults

Li¹,

Liu²,

Xiao³

et al. 2019

BMC Musculoskelet Disord

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BackgroundThe surgical procedures for mid-thoracic spinal tuberculosis mainly include anterior transthoracic debridement and fusion and posterior transpedicular debridement and fusion. Until now, the surgical choice is still controversial. This study aims to compare the clinical efficacy of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic (T5–9) spinal tuberculosis in adult patients.MethodsEighty-seven cases with mid-thoracic spinal tuberculosis were treated with anterior transthoracic debridement and fusion (Group A, n = 39) and posterior transpedicular debridement and fusion (Group B, n = 48) from January 2007 to June 2014. Parameters including the operation time, blood loss, time of ESR and CRP decreasing to the normal level, time of abscess disappearance, time of bone graft fusion, rate of surgical complications, Visual Analog Scale (VAS) score, kyphosis angle and SF-36 scale were compared between two groups to evaluate their therapeutic effects.ResultsAll patients were followed up for 5–10 years with the mean of 6.2 ± 1.1 years. No significant differences were observed regarding the gender composition ratio, age, course of disease, number of lesion segments, and preoperative indexes of ESR, CRP, VAS score, kyphosis angle and SF-36 scale between the two groups. Besides, no significant differences were observed regarding VAS score, kyphosis angle and SF-36 scale between the two groups in the 5th postoperative year (P > 0.05). However, the operation time (158.2 ± 10.7 min vs. 183.7 ± 14.1 min), blood loss (517.9 ± 76.5 ml vs.714.6 ± 57.4 ml), time of ESR (2.3 ± 1.1 months vs.3.1 ± 1.4 months) and CRP (1.1 ± 0.3 months vs.1.2 ± 0.6 months) decreasing to the normal level, time of abscess disappearance (2.7 ± 1.6 months vs.4.9 ± 1.9 months), and time of bone graft fusion (6.6 ± 0.8 months vs.8.0 ± 9.6 months) in Group A were less than those in Group B (P < 0.05).ConclusionsBoth anterior transthoracic debridement and fusion and posterior transpedicular debridement and fusion have a low risk of surgical complications and provide good quality of life for the patients with mid-thoracic (T5–9) spinal tuberculosis followed up in the mid-term. Moreover, the anterior procedure leads to early resolution of the disease and faster fusion.

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Section: Introductionmentioning

confidence: 99%

Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults

Li¹,

Liu²,

Xiao³

et al. 2019

BMC Musculoskelet Disord

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“…Tuberculous meningitis (TBM) is a worldwide disease with a case fatality rate of 15-68% (Sheu et al, 2009;Christensen et al, 2011;Bahr et al, 2018;Thakur et al, 2018), and more than half of survivors are left with neurological sequelae (Hosoglu et al, 2002;Chiang et al, 2014;Thakur et al, 2018). The early diagnosis and treatment of tuberculous meningitis has long been recognized as the most important prognostic factor (Hosoglu et al, 2002;Katti, 2004;Bahr et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A Diagnostic Formula for Discrimination of Tuberculous and Bacterial Meningitis Using Clinical and Laboratory Features

Yang

Kun-nan

et al. 2020

Front. Cell. Infect. Microbiol.

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Background: The discrimination of tuberculous meningitis and bacterial meningitis remains difficult at present, even with the introduction of advanced diagnostic tools. This study aims to differentiate these two kinds of meningitis by using the rule of clinical and laboratory features. Methods: A prospective observational study was conducted to collect the clinical and laboratory parameters of patients with tuberculous meningitis or bacterial meningitis. Logistic regression was used to define the diagnostic formula for the discrimination of tuberculous meningitis and bacterial meningitis. A receiver operator characteristic curve was established to determine the best cutoff point for the diagnostic formula. Results: Five parameters (duration of illness, coughing for two or more weeks, meningeal signs, blood sodium, and percentage of neutrophils in cerebrospinal fluid) were predictive of tuberculous meningitis. The diagnostic formula developed from these parameters was 98% sensitive and 82% specific, while these were 95% sensitive and 91% specific when prospectively applied to another 70 patients. Conclusion: The diagnostic formula developed in the present study can help physicians to differentiate tuberculous meningitis from bacterial meningitis in high-tuberculosis-incidence-areas, particularly in settings with limited microbiological and radiological resources.

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“…Tuberculosis of the central nervous system accounts for approximately 5-10% of extrapulmonary cases of TB [2]. Tuberculous meningitis (TBM) is the most life-threatening form of extrapulmonary tuberculosis and neuro-tuberculosis is the most common presentation [3].…”

Section: Introductionmentioning

confidence: 99%

Mri Evaluation of Intracranial Complications of Tuberculosis.

Parida

Makasare²,

Boddireddy

2020

PIJR

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Tuberculosis of CNS accounts for approximately 5-10% of extra-pulmonary TB cases. Intracranial manifestations of CNS TB include tubercular meningitis,complications of tuberculous meningitis,pachymeningitis,parenchymal tuberculosis. The first choice of imaging in CNS TB is MRI because of its inherent sensitivity and specificity in the detection of early subtle lesions. Our Aim includes Detection & characterization of various MRI findings in Intracranial tuberculosis. MRI brain was done in 60 patients with signs and symptoms of CNS involvement. Out of which, 2 patients (3%) were found without any neuro-radiological abnormality and were excluded. In rest of patients (n=58; 97%) one or more than one finding was present in a single patient; Leptomeningeal enhancement (n= 37; 61%), Tuberculomas (n=32; 53%), Hydrocephalus (n=17;28%),Infarcts (n=14;23%),Basal exudates (n= 11;18%) were more often present.

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The Global Neurological Burden of Tuberculosis

Cited by 38 publications

References 70 publications

Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults

Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults

A Diagnostic Formula for Discrimination of Tuberculous and Bacterial Meningitis Using Clinical and Laboratory Features

Mri Evaluation of Intracranial Complications of Tuberculosis.

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