The Global Landscape of the Burden of Depressive Symptoms/Major Depression in Individuals Living With HIV/AIDs and Its Effect on Antiretroviral Medication Adherence: An Umbrella Review

Necho, Mogesie; Zenebe, Yosef; Tiruneh, Chalachew; Ayano, Getinet; Yimam, Bethlehem

doi:10.3389/fpsyt.2022.814360

Cited by 3 publications

(5 citation statements)

References 36 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A substantial body of research documents the negative association between depression and HIV care continuum outcomes. Depression has been associated with increased odds of lower antiretroviral a therapy (ART) use or poorer adherence [8][9][10][11] and poorer retention in HIV care [12]. Longitudinal studies demonstrate the harmful impact of depression over time.…”

Section: Introductionmentioning

confidence: 99%

Closing the gaps in the continuum of depression care for persons with HIV: modeling the impact on viral suppression in the United States

Koenig

Khurana

Islam

et al. 2023

Aids

View full text Add to dashboard Cite

Objective:Depression is prevalent among persons with HIV (PWH) and is associated with poorer adherence and lack of viral load suppression (VLS). When treated for depression, PWH are more likely to stay in HIV care and adhere to medications; however, for many PWH, depression is not adequately diagnosed or treated. We adapted Progression and Transmission of HIV (PATH 3.0), a U.S. agent-based dynamic stochastic simulation model, by incorporating a continuum of depression care and estimating the impact on VLS of an enhanced depression diagnosis and care scenario (EDC).Methods:We compared EDC – whereby every PWH is assessed for depression, gets treatment if diagnosed, and of those, half achieve remission – to a status quo scenario (SQ) on VLS. Based on published findings, assumptions for SQ were: 34.7% depressed, 45% diagnosed, 55.3% treated and 33% of treated achieving remission. Compared to PWH without depression, we assumed the probability of being non-virally suppressed increased by 1.57 times for PWH with depression (PWH-D), and by 0.95 times for PWH with remitted depression.Results:There was an average increase of 14.6% (11.5–18.5) in the proportion of PWH-D who achieved VLS in EDC compared to SQ. Among all PWH, there was a 4.7% (3.4–6.0) increase in the proportion who achieved VLS in EDC compared to SQ.Conclusions:Fully diagnosing and adequately treating depression would improve health and quality of life for a substantial proportion of PWH-D and result in a nearly 5% increase in expected rates of VLS in the United States, supporting national prevention goals.

show abstract

Section: Introductionmentioning

confidence: 99%

Closing the gaps in the continuum of depression care for persons with HIV: modeling the impact on viral suppression in the United States

Koenig

Khurana

Islam

et al. 2023

Aids

View full text Add to dashboard Cite

show abstract

“…Depression is the most common neuropsychiatric disorder among PLWH. Depression results in poor physical health [ 4 ], reduced ART adherence [ 5 – 7 ], treatment failure [ 8 ], reduced quality of life [ 9 , 10 ], increased suicidal behaviours [ 11 , 12 ] and HIV-related mortality among PLWH [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of depression among people living with HIV in rural hospitals in South-Western Nigeria-Association with clinico-demographic factors

Adedeji,

Ma,

Raji

et al. 2023

AIDS Res Ther

View full text Add to dashboard Cite

Major depression is the most common neuropsychiatric disorder among people living with HIV (PLWH) and is predictive of high morbidity and mortality among them. This study estimated the prevalence and explored factors associated with depression among PLWH in two rural secondary health facilities providing anti-retroviral therapy (ART) services in Southwestern Nigeria between September and December 2020. The Patient Health Questionnaire-9 (PHQ-9) was used to screen and identify PLWH aged 18 years or older with depression. Descriptive statistics, bivariate and multivariate analyses were performed with SPSS version 23. A total of 172 respondents were screened. The prevalence of depression was 16.3% (95% CI 11.1%, 22.7%). Mild, moderate, and moderately severe depression was identified in 17 (9.9%), 8(4.7%) and 3(1.7%) of the participants, respectively. One (0.6%) respondent had suicidal ideation. Of PLWH with any depression, 20/28(71.4%) were within the 40–59 years of age range. None of the participants was on antidepressants. The factor most associated with depression was hypertension, with adjusted odd ratios of 9.8(95% CI 3.5–27.3, p < 0.0001). The study highlights the importance of screening for the severity of depression among PLWH in rural hospitals providing ART services in Africa. PLWH with comorbid hypertension were more likely to suffer from some form of depression.

show abstract

“…The estimated global prevalence of depressive symptoms among PLWHA is 34.17%. 8 A systematic and meta-analysis study reports the prevalence of depressive symptoms using screening tool to be 26.0% in sub-Saharan Africa, and 44.7% in South Africa, respectively. 9 In addition, the prevalence of depressive symptoms among HIV-positive individuals in sub-Saharan Africa was 27.0% with a mean estimate of 6.376 million, while in South Africa it was 29.1% with a mean estimate of 2.076 million.…”

Section: Introductionmentioning

confidence: 99%

“…18,24,27 Yet, research has shown that HIV-related clinical variables associated with depressive symptoms in PLWHA include side effects of ART, [28][29][30] and poor adherence to ART. 1,8,13,15 Depressive symptoms are detrimental to the health of PLWHA, particularly when adherence to ART is irregular. A recent study found that PLWHA with depressive symptoms were 2.6 times more likely to not adhere to their ART medication than their counterparts.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the setting of our study is rural, where psychological services are rarely readily available in some primary health facilities in South Africa; consequently, the higher depressive symptoms observed in our study are concerning and reflective of the significantly higher HIV prevalence in South Africa. In addition, the high association between depressive symptoms and antiretroviral medication and non-adherence 8 suggests that the mental health of PLWHA should be prioritised. This may help to cushion the health economy burden of depressive symptomology on PLWHA.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Depressive Symptoms and Associated Factors Among People Living with HIV/AIDS and Undergoing Antiretroviral Therapy: A Cross-Sectional Study in the Amathole District, South Africa

Njajula,

Okafor

2023

JMDH

View full text Add to dashboard Cite

Background and Aim: People living with HIV/AIDS (PLWHA) are susceptible to depressive symptoms. Consequently, we examined the prevalence of depressive symptoms and associated factors among PLWHA and on antiretroviral therapy (ART) in South Africa. Methods: We conducted a cross-sectional study of 150 PLWHA on ART in primary health facilities in Amathole District, Eastern Cape Province of South Africa. A self-designed questionnaire solicits information on participant's demographic characteristics. Patient Health Questionnaire (PHQ-9) rating scale was used to screen depressive symptoms (cut-off point of ≤5). Data was also collected on lifestyle behaviours, early ART initiation, medication adherence, depression-related symptoms, and depression severity scores. Results: The prevalence of depressive symptoms was 41.3%, with females exhibited higher prevalence (67.7%) compared to males (32.3%). Depressive symptoms was significantly associated with unemployment, female gender, low educational level, and HIV staging. Predictors of depressive symptoms were lower CD4 cell count of 350 to 500 (OR=4.0; 1.05-17.50), pain and discomfort (OR=6.2; 1.69-28.01), suffering from complications and opportunistic diseases (OR=1.5; 0.19-3.49), experiencing discrimination at health facilities (OR=11.0; 0.93-167.1), and workplaces (OR=18.1; 2.53-43.23), and being satisfied with ART treatment results (OR=0.1; 0.05-1.06). Conclusion: Depressive symptoms was high among PLWHA in this setting, and particularly in women compared to men. Low CD4 cell count, pain and discomfort, complications and opportunistic diseases, discrimination at health facilities and workplaces were more likely susceptible to depressive symptoms. Mental health screening should be prioritised in primary health care facilities for early detection of depressive symptoms to facilitate prompt referrals and treatment.

show abstract

The Global Landscape of the Burden of Depressive Symptoms/Major Depression in Individuals Living With HIV/AIDs and Its Effect on Antiretroviral Medication Adherence: An Umbrella Review

Cited by 3 publications

References 36 publications

Closing the gaps in the continuum of depression care for persons with HIV: modeling the impact on viral suppression in the United States

Closing the gaps in the continuum of depression care for persons with HIV: modeling the impact on viral suppression in the United States

Prevalence of depression among people living with HIV in rural hospitals in South-Western Nigeria-Association with clinico-demographic factors

Depressive Symptoms and Associated Factors Among People Living with HIV/AIDS and Undergoing Antiretroviral Therapy: A Cross-Sectional Study in the Amathole District, South Africa

Contact Info

Product

Resources

About