Introduction and Background The Global Fund to Fight AIDS, Tuberculosis and Malaria was founded in 2002 as a public-private partnership between governments, the private sector, civil society, and populations affected by the three diseases. As a financing mechanism, the Global Fund raises and disburses funds to principal recipients (e.g., government agencies, NGOs, or local offices of multilateral organizations) and is among the largest global health initiatives, disbursing nearly US$4 billion per year in over 100 countries toward its mission of accelerating the end of the three epidemics [1]. Four principles guide the work of the Global Fund: country ownership, partnership, performance-based financing, and transparency [2]. The Global Fund encourages country ownership through engaging a variety of in-country stakeholders to harness local perspectives and expertise in decision-making, including governments, bilateral and multilateral donors, the private sector, technical partners, foundations, civil society, representatives from key affected populations, and researchers, among others [3, 4]. Partnership has been a distinguishing feature of the Global Fund since its founding. The Global Fund's concept of partnership supports alignment with national health