The Global Burden of Headache

Saylor, Deanna; Steiner, Timothy J.

doi:10.1055/s-0038-1646946

Cited by 220 publications

(91 citation statements)

References 68 publications

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“…With regard to individual headache types, in the Dutch study, 12.4% of the responders had migraine headaches, 17% had tension-type headaches, and 10.4% another type of headache [7]. Similar prevalence was found in other studies [1,7,31,32]. In our study, 16.53% of subjects had migraines, 21.91% had tension-type headaches, and 18.19% had some other type of headache.…”

Section: Discussionsupporting

confidence: 88%

“…With regard to absence from work in the past 30 days, subjects with migraines (7.1%) missed work statistically significantly more frequently compared with subjects with tension-type headaches (2.2%) and other headache types (2.2%). On average, 3.6% of our subjects had missed work in the past 30 days, which was a higher percentage than that reported in other studies [1,7]. In a study by Pop and associates, 2.5% of headache sufferers missed 1 or more work days in a month due to a headache [7].…”

Section: Discussioncontrasting

confidence: 54%

“…Headaches are one of the most frequent complaints in medicine in general and a frequent disorder in the working population that significantly affects absenteeism and loss of productivity; however, its effect on work efficiency has been insufficiently studied [1][2][3]. Some primary headaches are commonly linked with a broad range of psychiatric comorbidities [4].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Individual Headache Types on the Work and Work Efficiency of Headache Sufferers

Simić

Rabi-Zikic

Villar

et al. 2020

IJERPH

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Background: Headaches have not only medical but also great socioeconomic significance, therefore, it is necessary to evaluate the overall impact of headaches on a patient’s life, including their work and work efficiency. The aim of this study was to determine the impact of individual headache types on work and work efficiency. Methods: This research was designed as a cross-sectional study performed by administering a questionnaire among employees. The questionnaire consisted of general questions, questions about headache features, and questions about the impact of headaches on work. Results: Monthly absence from work was mostly represented by migraine sufferers (7.1%), significantly more than with sufferers with tension-type headaches (2.23%; p = 0.019) and other headache types (2.15%; p = 0.025). Migraine sufferers (30.2%) worked in spite of a headache for more than 25 h, which was more frequent than with sufferers from tension-type and other-type headaches (13.4%). On average, headache sufferers reported work efficiency ranging from 66% to 90%. With regard to individual headache types, this range was significantly more frequent in subjects with tension-type headaches, whereas 91–100% efficiency was significantly more frequent in subjects with other headache types. Lower efficiency, i.e., 0–40% and 41–65%, was significantly more frequent with migraine sufferers. Conclusions: Headaches, especially migraines, significantly affect the work and work efficiency of headache sufferers by reducing their productivity. Loss is greater due to reduced efficiency than due to absenteeism.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Individual Headache Types on the Work and Work Efficiency of Headache Sufferers

Simić

Rabi-Zikic

Villar

et al. 2020

IJERPH

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“…Headache is one of the most common neurological disorders and it is one of the leading causes of healthrelated problems worldwide. In 2010, tension type headache and migraine were the second and third most prevalent conditions in the world, respectively, according to the Global Burden of Disease (GBD) study [54,55]. Furthermore, the GBD study in 2015 established that headache is responsible [56] for more disability adjusted life years than all other neurological disorders in combination.…”

Section: Discussionmentioning

confidence: 99%

Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

et al. 2020

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Background: The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund's adjuvant (CFA)-induced orofacial pain, involving finding the shift point regarding small molecule neurotransmitter concentrations changes vs. that of the previously characterized headache-related neuropeptides. The investigated neurotransmitters consisted of glutamate, γ-aminobutyric acid, noradrenalin and serotonin. Furthermore, in light of its influence on glutamatergic neurotransmission, we measured the level of kynurenic acid (KYNA) and its precursors in the kynurenine (KYN) pathway (KP) of tryptophan metabolism. Methods: The effect of CFA was evaluated in male Sprague Dawley rats. Animals were injected with CFA (1 mg/ml, 50 μl/animal) into the right whisker pad. We applied high-performance liquid chromatography to determine the concentrations of the above-mentioned compounds from the trigeminal nucleus caudalis (TNC) and somatosensory cortex (ssCX) of rats. Furthermore, we measured some of these metabolites from the cerebrospinal fluid and plasma as well. Afterwards, we carried out permutation t-tests as post hoc analysis for pairwise comparison.Results: Our results demonstrated that 24 h after CFA treatment, the level of glutamate, KYNA and that of its precursor, KYN was still elevated in the TNC, all diminishing by 48 h. In the ssCX, significant concentration increases of KYNA and serotonin were found.Conclusion: This is the first study assessing neurotransmitter changes in the TNC and ssCX following CFA treatment, confirming the dominant role of glutamate in early pain processing and a compensatory elevation of KYNA with anti-glutamatergic properties. Furthermore, the current findings draw attention to the limited time interval where medications can target the glutamatergic pathways.

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“…According to the criteria of the International Headache Society, if the headache symptoms last at least 15 days each month for at least 3 months, migraine, tension type and cluster headaches are considered as chronic (9). tients (10)(11)(12), so much that it is the second cause of disability in the world according to recent studies (10). The disability which is due to headache represents the limitation of an activity that a person is able to perform normally.…”

Section: Introductionmentioning

confidence: 99%

Predictive Factors for Disability in Patients with Acute and Chronic Headache

et al. 2019

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Background: Headache is one of the most common types of pain which is considered among the most disabling of diseases. However, the severity of disability in some headache patients is more than others. Objectives: The aim of the present study was to compare different types of headache regarding pain-related variables and psychological factors. We also examined the predicting factors of disability in patients with headache. Methods: This cross-sectional study was performed in 320 patients with various types of headache based on the International Headache Society criteria, which was assessed by neurologists. Data was collected using migraine disability assessment for disability, frequency of headache and for pain intensity, patient health questionnaire for depression, and pain anxiety symptoms scale for pain-related anxiety. ANOVAs and post hoc Tukey's tests were used for comparing various types of headaches regarding pain-related and psychological factors. Regression analyses assessed the relation of pain-related and psychological variables with disability. Results: Patients with different types of headache revealed no significant differences regarding pain intensity (P = 0.27). Migraine patients showed the most pain frequency and chronicity compared to the other patients (P = 0.000). The levels of disability (P = 0.000), anxiety (P = 0.000) and depressive symptoms (P = 0.000) were also higher in patients with migraine compared to patients suffering from cluster or tension type headache. Pain chronicity (P = 0.01), anxiety (P = 0.007) and depression (P = 0.002) made significant contributions to the explanation of variance in 'disability'. Conclusions: The findings add further evidence to the relevance of cognitive-behavioral models of pain suggesting an important role for pain-related emotions regarding the consequences of pain (e.g. disability). The current data could help clinicians to decide which factors should be considered for a successful treatment of disability in headache patients.

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The Global Burden of Headache

Cited by 220 publications

References 68 publications

Impact of Individual Headache Types on the Work and Work Efficiency of Headache Sufferers

Impact of Individual Headache Types on the Work and Work Efficiency of Headache Sufferers

Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

Predictive Factors for Disability in Patients with Acute and Chronic Headache

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