The Global Burden of Diabetes

Ali, Mohammed K.; Galavíz, Karla I.; Weber, Mary Beth; Narayan, K.M. Venkat

doi:10.1002/9781118924853.ch5

Cited by 3 publications

(2 citation statements)

References 183 publications

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“…The significant global impact of this condition is acknowledged internationally, with diabetes ranking highly on the international health agenda [7]. With 5% of the UK population affected by this condition, diabetes has become a major challenge in 21 st century healthcare [8,9]. This is largely due to the associated micro and macro-vascular complications of diabetes, affecting diabetic populations in both developed and developing countries [7,9].…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Diabetic nephropathy: Is there a role for oxidative stress?

Sagoo

Gnudi

2018

Free Radical Biology and Medicine

170

110

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Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy. Studies in experimental animal models of diabetes strongly implicate oxidant species as a major determinant in the pathophysiology of diabetic kidney disease. The translation, in the clinical setting, of these concepts have been quite disappointing, and new theories have challenged the concepts that oxidative stress per se plays a role in the pathophysiology of diabetic kidney disease. The concept of mitochondrial hormesis has been introduced to explain this apparent disconnect. Hormesis is intended as any cellular process that exhibits a biphasic response to exposure to increasing amounts of a substance or condition: specifically, in diabetic kidney disease, oxidant species may represent, at determined concentration, an essential and potentially protective factor. It could be postulated that excessive production or inhibition of oxidant species formation might result in an adverse phenotype. This review discusses the evidence underlying these two apparent contradicting concepts, with the aim to propose and speculate on potential mechanisms underlying the role of oxidant species in the pathophysiology of diabetic nephropathy and possibly open future more efficient therapies to be tested in the clinical settings.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Diabetic nephropathy: Is there a role for oxidative stress?

Sagoo

Gnudi

2018

Free Radical Biology and Medicine

170

110

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“…In 2021, approximately 537 million individuals had diabetes worldwide ( 2 ). Diabetes disproportionately affects the global south country ( 3 ). The African region is particularly affected, with an estimated 23.6 million adults living with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Diabetic retinopathy incidence, predictors and its association with longitudinal fasting blood sugar level changes among diabetes mellitus patients in Ethiopia: joint model

Abuhay,

Lakew,

Wolde

et al. 2024

Front. Endocrinol.

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BackgroundDiabetes mellitus (DM) is a global public health problem characterized by an elevated blood glucose level. Monitoring blood sugar levels is vital for effective diabetes management and preventing complications. However, the association between longitudinal biomarkers and the incidence of diabetic complications is often overlooked. Therefore, this study aimed to assess the incidence of diabetic retinopathy, predictors, and association with longitudinal fasting blood sugar level changes among diabetes mellitus patients in Ethiopia.MethodsA multicenter retrospective follow-up study was carried out in referral hospitals in Amhara region, Ethiopia. A random sample of 462 newly diagnosed DM patients was selected. The proportional hazard assumption was checked for the survival sub-model, and for the longitudinal sub-model, the normality assumption was checked. Then the joint modeling with time-dependent lagged parameterizations was fitted. Model assumptions and comparisons were checked. Finally, the hazard ratio with a 95% confidence interval (CI) with a corresponding P-value<0.05 was used to identify predictors.ResultsIn this study, Overall, 54 patients developed DR, and the incidence rate was 2.33 per 1000 person-months over the follow-up period, with a 95% CI of [1.78, 3.05]. Rural residence (AHR = 2.21, 95% CI: [1.21, 4.05]), hypertension co-morbidity (AHR = 3.01, 95% CI: [1.85, 6.53]), and longer duration of DM (>5 years) (AHR = 2.28, 95% CI: [1.91, 5.15]) were important predictors for the incidence of DR. In addition, the incidence of DR was substantially correlated with the time-dependent lagged value of FBS change (AHR = 4.20, 95% CI [1.62, 10.85]).ConclusionsIn this study, the incidence of diabetic retinopathy was somewhat high when compared to prior similar studies in Ethiopia. A joint model of longitudinal fasting blood sugar level changes was significantly associated with an increased risk of DR. Besides, being rural residence, hypertension co-morbidity, and a longer duration of DM were significant predictors for the incidence of DR. Therefore, public awareness, an integrated care approach, and prioritizing glycemic control are highly recommended.

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Biocatalyzed synthesis of antidiabetic drugs: A review

Alcántara

2017

Biocatalysis and Biotransformation

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The Global Burden of Diabetes

Cited by 3 publications

References 183 publications

Diabetic nephropathy: Is there a role for oxidative stress?

Diabetic nephropathy: Is there a role for oxidative stress?

Diabetic retinopathy incidence, predictors and its association with longitudinal fasting blood sugar level changes among diabetes mellitus patients in Ethiopia: joint model

Biocatalyzed synthesis of antidiabetic drugs: A review

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