The GLIM criteria for adult malnutrition and its relation with adverse outcomes, a prospective observational study

Martín, Carlos Alfredo Galindo; Vázquez, Verónica Angélica Aportela; Hernández, Fabiola Becerril; Medina, Carlos Rodrigo Aguilar; Carrillo, Sandra Lizeth Ayala; Flores, Arely Chávez; Almanza, Eviletth Gabriel; Agredano, Martha Irene Guizar; Vilchis, José David Montoya

doi:10.1016/j.clnesp.2020.06.015

Cited by 23 publications

(7 citation statements)

References 18 publications

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“…Diagnosis of malnutrition needs a complete nutritional assessment, which is often challenging to perform during a hospital stay [1,2]. Consequently, the real prevalence of malnutrition is not well-established, owing to the absence of a broadly accepted clinical definition [9,10]. Specific identification and optimal management of this clinical condition could improve the prognosis of malnourished patients, reducing both the length of the hospital stay and costs related to hospitalization [10].…”

Section: Introductionmentioning

confidence: 99%

Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management

et al. 2022

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Malnutrition in hospitalized patients heavily affects several clinical outcomes. The prevalence of malnutrition increases with age, comorbidities, and intensity of care in up to 90% of old populations. However, malnutrition frequently remains underdiagnosed and undertreated in the hospital. Thus, an accurate screening to identify patients at risk of malnutrition or malnourishment is determinant to elaborate a personal nutritional intervention. Several definitions of malnutrition were proposed in the last years, affecting the real frequency of nutritional disorders and the timing of intervention. Diagnosis of malnutrition needs a complete nutritional assessment, which is often challenging to perform during a hospital stay. For this purpose, various screening tools were proposed, allowing patients to be stratified according to the risk of malnutrition. The present review aims to summarize the actual evidence in terms of diagnosis, association with clinical outcomes, and management of malnutrition in a hospital setting.

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Section: Introductionmentioning

confidence: 99%

Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management

et al. 2022

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“…The dynamic of nutritional status evaluated by GLIM criteria along with radiotherapy NPC patients with malnutrition assessed by GLIM criteria during the whole process of radiotherapy was shown in Table 2. 16.8% of patients were malnutrition before radiotherapy, however, 91.2% were malnutrition at the end of radiotherapy, which exhibiting an increased prevalence of malnutrition with the radiotherapy process. Besides nutritional status, according to GLIM criteria, we also investigated the phenotypic and etiologic criteria of GLIM criteria.…”

Section: Summarization Of Baseline Information Of Patientsmentioning

confidence: 95%

“…Regarding malnutrition, more complicated than what it shows on the face value, for a long term, the de nition upon it varies in terms of criteria adapted and parameters included, plus, stands devoid of comprehensively uni ed standardization instead the divided diagnostic guidelines [14][15][16]. The Global Leadership Initiative in Malnutrition (GLIM) has constantly conducted efforts on clarifying malnutrition, and recent updates had been released [17], which advances further the de nition on malnutrition.…”

Section: Introductionmentioning

confidence: 99%

Malnutrition According to GLIM Criteria Acts as a Risk Factor for Survival of Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy : A Retrospective Study Highlighting the Nutritional Management in Radiotherapy

Wan¹,

Zhang²,

Chen³

et al. 2021

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Background Nutritional status of nasopharyngeal carcinoma (NPC) patients lying at a high risk of nutrition defect to a great extent determines the post-treatment outcomes, which deserves thorough observation. However, limited ever-conducted studies regarding the NPC patients’ malnutrition by effective methods like the Global Leadership Initiative in Malnutrition (GLIM) criteria heavily obstructed this prospect. Our study aimed to investigate the incidence of malnutrition in NPC cancer patients using GLIM criteria and explore the relationships between malnutrition and adverse effects, survival status.Methods A retrospective chart review of 113 patients with NPC from December 2016 to October 2019. The nutritional status of NPC undergoing radiotherapy (RT) was determined by GLIM criteria at three-time points: pre-RT, in the middle of RT, and at the end of RT. The adverse effects were graded according to the Radiation Therapy Oncology Group (RTOG) scoring criteria. Kaplan–Meier method was used to compare survival outcomes, and the differences were evaluated using the log-rank test.ResultsNineteen cases (16.8%) were malnutrition before radiotherapy; overall stage (p=0.017) and induction chemotherapy(p=0.002) contributed to pre-radiotherapy malnourishment, and the nutritional status worsened with radiotherapy. Of the phenotypic GLIM criteria, low fat free mass index (FFMI) before radiotherapy was associated with mucositis and radiodermatitis (p<0.05). With a median follow-up of 28.3 months, the Kaplan-Meier curve indicated that malnutritional patients had significantly poorer Progress Free survival (PFS); 2-year PFS was 88.9% in the well-nourishment group vs. 62.1% in the malnutrition group (p=0.015). In multivariate analysis, nutritional status and gender were independent prognostic factors of poorer PFS (HR 3.387, 95%CI 1.299-8.834, p=0.013 and HR 5.698, 95%CI 1.290-25.168, p=0.022).Conclusion Malnutrition is common in NPC patients, and it increases significantly during radiotherapy. Malnutrition, according to GLIM criteria, is correlated with survival. Our study could justify the effectiveness and usability of GLIM for NPC patients undergoing RT. Appropriate nutritional guidance or nutritional support should be taken to improve the NPC patients’ nutritional status during radiotherapy.

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“…GLIM criteria identify approximately 40% of hospitalized adults as cases of malnutrition, with a satisfactory validity criterion, and sensitivity and specificity above 80%, in line with SGA [170][171][172]. Other authors do not find such a high sensitivity, but do find a strong association with mortality and admission to a critical care unit [173]. The agreement of GLIM with other diagnostic tools is related to the screening tool chosen to perform the first step of the process [174], finding excellent concordance with SGA in critically ill patients with COVID-19 [175].…”

Section: And/aspen Tool (Aspen)mentioning

confidence: 96%

Malnutrition Screening and Assessment

et al. 2022

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Malnutrition is a serious problem with a negative impact on the quality of life and the evolution of patients, contributing to an increase in morbidity, length of hospital stay, mortality, and health spending. Early identification is fundamental to implement the necessary therapeutic actions, involving adequate nutritional support to prevent or reverse malnutrition. This review presents two complementary methods of fighting malnutrition: nutritional screening and nutritional assessment. Nutritional risk screening is conducted using simple, quick-to-perform tools, and is the first line of action in detecting at-risk patients. It should be implemented systematically and periodically on admission to hospital or residential care, as well as on an outpatient basis for patients with chronic conditions. Once patients with a nutritional risk are detected, they should undergo a more detailed nutritional assessment to identify and quantify the type and degree of malnutrition. This should include health history and clinical examination, dietary history, anthropometric measurements, evaluation of the degree of aggression determined by the disease, functional assessment, and, whenever possible, some method of measuring body composition.

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The GLIM criteria for adult malnutrition and its relation with adverse outcomes, a prospective observational study

Cited by 23 publications

References 18 publications

Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management

Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management

Malnutrition According to GLIM Criteria Acts as a Risk Factor for Survival of Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy : A Retrospective Study Highlighting the Nutritional Management in Radiotherapy

Malnutrition Screening and Assessment

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