The glaucomatous visual field.

Drance, S M

doi:10.1136/bjo.56.3.186

Cited by 58 publications

(30 citation statements)

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“…In other words, interocular asymmetries are greater in PACG in both the superior and inferior fields. The results of comparing the mean asymmetry of nasal fields were not significant and may indicate a more universal vulnerability of these nerve fibre layers during early phases in each disease, 3,8,9 or a lack of sensitivity of AGIS scoring techniques to detect subtle differences in nasal field loss.…”

Section: Discussionmentioning

confidence: 80%

Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma

Wang

Gazzard

Foster

et al. 2004

Eye

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Aim To compare the interocular asymmetry in visual field loss of patients with primary open-angle (POAG) and primary angle-closure glaucoma (PACG). Methods Subjects entering a prospective, randomised, controlled trial of intraoperative 5-fluorouracil in glaucoma surgery in Singapore were included. Preoperative visual field testing was performed using automated white-on-white perimetry (24-2 test pattern, threshold program, Mk II, Model 750, ZeissHumphrey, San Leandro, CA, USA). A minimum of two tests were required with mean deviation within 2 dB on two tests, fixation losses o20%, false positives o33%, and false negatives o33%. The second field was scored using AGIS II criteria and the 'mean asymmetry score' defined as the mean difference between eyes for both AGIS scores and global indices. Results In 230 subjects assessed (128 POAG, 102 PACG), mean interocular asymmetry of visual field loss was greater for the PACG group. The mean AGIS asymmetry scores for total (PACG ¼ 9.2176.87 vs POAG ¼ 6.4875.58, P ¼ 0.001), superior (PACG ¼ 4.3173.39 vs POAG ¼ 3.3573.13, P ¼ 0.035), and inferior (PACG ¼ 4.4373.31 vs POAG ¼ 2.6472.77, Po0.0001) areas and mean deviation (MD) asymmetry scores (PACG ¼ 6.89713.22 vs POAG ¼ 1.66716.97, P ¼ 0.012) were all significantly different. Interocular correlation of visual field loss for POAG was significant; total AGIS, r ¼ 0.27 (P ¼ 0.003), superior field AGIS, r ¼ 0.24 (P ¼ 0.008), inferior field AGIS, r ¼ 0.34 (P ¼ 0.0001), and MD, r ¼ 0.27 (P ¼ 0.003). In PACG, there was no significant correlation between eyes; total AGIS, r ¼ À0.02 (P ¼ 0.85), superior field AGIS, r ¼ À0.02 (P ¼ 0.82), inferior field AGIS, r ¼ À0.17 (P ¼ 0.87), and MD, r ¼ 0.015 (P ¼ 0.89). Conclusion There was a greater asymmetry of visual field loss between eyes, as measured by AGIS scores and MD, in PACG than that in POAG.

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Section: Discussionmentioning

confidence: 80%

Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma

Wang

Gazzard

Foster

et al. 2004

Eye

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“…8 Finally, visual field defects associated with glaucoma usually occur initially in the superior visual field (corresponding to inferior pole defects). [35][36][37] The basis for these observations is unknown. It is possible that thinner RNFL in the inferior quadrant of OHT eyes is an early form of glaucoma that precedes detectable optic nerve and/or visual field defects.…”

Section: Discussionmentioning

confidence: 99%

The Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive, Normal, and Glaucomatous Eyes With Optical Coherence Tomography

Bowd

Weinreb²,

Williams³

et al. 2000

Arch Ophthalmol

267

159

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To quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in ocular hypertensive eyes with normal and glaucomatous eyes using the Optical Coherence Tomograph (OCT 2000, software version A4X1; Humphrey Instruments, San Leandro, Calif). Methods:The mean RNFL thickness of ocular hypertensive (n = 28) eyes was compared with age-matched normal (n = 30) and glaucomatous (n = 29) eyes. Subject eyes were classified into diagnostic groups based on intraocular pressure, stereoscopic disc photographs, and standard automated perimetry. Three circular scans were obtained for each eye at a diameter of 3.4 mm around the optic disc. In each eye, average RNFL thickness measurements were obtained in temporal, superior, nasal, and inferior quadrants. A single index of average RNFL thickness throughout 360°also was obtained.Results: Mean (95% confidence interval) RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes, 72.8 µm (66.4-78.1 µm) and 85.8 µm (80.2-91.7 µm), respectively. More specifically, RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes in the inferior quadrant, 84.8 µm (75.6-94.0 µm) vs 107.6 µm (99.3-115.9 µm); and in the nasal quadrant, 44.1 µm (37.5-51.7 µm) vs 61.8 µm (53.0-65.6 µm). Retinal nerve fiber layer was significantly thinner in glaucomatous eyes than in ocular hypertensive and normal eyes throughout 360°and in all quadrants. Conclusion:These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes.

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“…Glaucomatous defects include: diffuse loss; 44 arcuate scotomas within the central 25°( which classically respect the horizontal midline); nasal step; hemifield loss; and a small remaining central or temporal island in advanced cases. [45][46][47][48][49] Visual field analysis in the secondary and tertiary care sectors is commonly performed with the Humphrey Field Analyzer (HFA), or similar instruments. The most commonly used examinations are the full threshold and SITA 24-2 strategies, which are lengthy (up to 30 minutes to examine both eyes) and, like all perimetric examinations, require an attentive patient with good observational skills.…”

Section: Perimetric Examination Of the Visual Fieldmentioning

confidence: 99%

“…108 Zangwill and colleagues 36 agreed with other researchers 89 that the number featured as one of the GDx's optimum parameters and found 41% sensitivity at 90% specificity for this parameter. Issues such as inclusion criteria and the subsequent effects on apparent diagnostic precision are discussed in greater detail in the introduction to Chapter 7 (p. 47) Of the other GDx parameters, some are considered to be of minimal utility and may give clinically misleading information when they are flagged as outside normal limits.…”

Section: Sensitivity and Specificitymentioning

confidence: 99%

The effectiveness of the Heidelberg Retina Tomograph and laser diagnostic glaucoma scanning system (GDx) in detecting and monitoring glaucoma

Kwartz

Henson²,

Harper³

et al. 2005

Health Technol Assess

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The glaucomatous visual field.

Cited by 58 publications

References 0 publications

Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma

Interocular asymmetry of visual field defects in primary open angle glaucoma and primary angle-closure glaucoma

The Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive, Normal, and Glaucomatous Eyes With Optical Coherence Tomography

The effectiveness of the Heidelberg Retina Tomograph and laser diagnostic glaucoma scanning system (GDx) in detecting and monitoring glaucoma

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