The glaucomas in aphakia and pseudophakia

Tomey, Karim F.; Traverso, Carlo Enrico

doi:10.1016/0039-6257(91)90124-x

Cited by 52 publications

(32 citation statements)

References 251 publications

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“…Aphakia is also a known risk factor for failure in adult trabeculectomy surgery. 25,26 Previous reports of outcome of filtering surgery without the use of any adjunctive antifibrotic agents in the management of a paediatric glaucoma have been disappointing. [9][10][11] The use of antifibroproliferative agents such as 5-fluorouracil (5-FU) 27,28 and MMC, 29,30 which may improve the surgical prognosis, has been studied extensively in adults.…”

Section: Resultsmentioning

confidence: 99%

Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

Mandal

Bagga

Nutheti³

et al. 2003

Eye

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Section: Resultsmentioning

confidence: 99%

Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

Mandal

Bagga

Nutheti³

et al. 2003

Eye

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“…The most common cause of the failure of this surgery is scarring secondary to fibroblast proliferation and fibrosis at the episcleral conjunctival interface [1]. The risk factors which may influence the outcome of filtering surgery include aphakia [2]and youth [3], ocular inflammation and neovascular glaucoma [4], ethnic origin [5], previous surgery [6], long-term use of topical antiglaucoma medications and possibly diabetes [7, 8, 9]. The mechanism or mechanisms by which these factors reduce success is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hydroxyurea on Rabbit Subconjunctival Fibroblast Culture and Use of Hydroxyurea in Rabbits after Glaucoma Filtration Surgery

Yücel¹,

Bağcı

Duranoğlu³

et al. 1999

Ophthalmologica

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In an in vitro study, rabbit subconjunctival fibroblasts were cultured and the effects of an antineoplastic drug, hydroxyurea (HU), on fibroblast proliferation and fibroblast attachment was investigated. The effects of HU were compared with those of mitomycin C (MMC). Different concentrations of HU and MMC were added to culture medium. The HU doses which led to 50% of inhibition (ID₅₀) and the dose which led to about 90% of inhibition (subtoxic high dose, STHD) were determined to be 8 and 1,000 μg/ml, respectively. ID₅₀ of MMC and its STHD which led to about 100% inhibition were found to be 0.01 and 1 μg/ml, respectively. Reversibility studies revealed that inhibition disappeared depending on the dose and incubation period of both HU and MMC. In an in vivo study, glaucoma filtration surgery (GFS) was performed in rabbits which were treated with HU (treatment group) and distilled water (control group). Tissue samples were taken from the subconjunctival area treated at 1 h, 1 day, 5 days and 30 days postoperatively. The biopsy specimens were then placed in tissue culture media. Fibroblast outgrowth rates detected in the HU group were found to be significantly lower than those in the control group in the specimens taken at the end of the first hour. The difference was significant on culture days 9–15 in the biopsy specimens taken on day 1 while it was not significant in those taken on days 5 and 30.

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“…Failure was secondary to external conjunctival bleb failure in 10 eyes, to internal clo sure of the anterior chamber Supramid tube in 5 eyes, to phthisis bulbi secondary to choroidal hemorrhage in 2 eyes and to external erosion of the Silastic end in l eye. 12 Mortality during long-term follow-up was high in our se ries. The complications of an underlying diabetes mellitus were the most common causes of death (15 out of 22 pa tients).…”

Section: Resultsmentioning

confidence: 95%

“…External bleb scarring was considered the most common cause of surgical failure [3,4,11,12], In our sample IOP control in the early postoperative peri od proved very difficult. Sixteen out o f 28 patients (57.1%) developed IOPs below the manufacturer's stated lower limit of closing pressure (9 mmHg); the 7 patients who had se rous choroidal effusion belonged to this group.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Results of Krupin-Denver Valve Implants in Filtering Surgery for Neovascular Glaucoma

Mastropasqua

Carpineto²,

Ciancaglini³

et al. 1996

Ophthalmologica

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The long-term results obtained with the Krupin eye short valve shunt in 28 eyes with neovascular glaucoma were retrospectively analyzed by means of Kaplan-Meier survival curve. The preoperative intraocular pressures (IOPs) ranged from 28 to 62 mm Hg (mean, 36.8 ± 5.8 mm Hg). Success was considered an IOP of less than 22 mm Hg and greater than 5 mm Hg without medication (complete success) or with medication (qualified success) without additional glaucoma filtering surgery or devastating complications. Postoperative success was obtained in 10 out of 28 eyes after a mean follow-up period of 58.4+23.02 months (range, 10-108 months). The 3- and 6-year life table success rates were 66 and 34%, respectively. Early complications were: shallow or flat anterior chamber (15 patients, 53.6%), hypotony (16 patients, 57.1%), hypertony (7 patients, 25%), serous choroidal effusion (7 patients, 25%), fibrinous uveitis (5 patients, 17.9%), blockage of the intracameral portion of the tube by fibrin (5 patients, 17.9%), choroidal hemorrhage (2 patients, 7.1%). Late complications were: external conjunctival bleb failure (12 patients, 42.9%), blockage of the intracameral portion of the tube by fÍbrovascular tissue (5 patients, 17.9%), cataract (2 patients, 7.1%), bullous keratopathy (2 patients, 7.1%), external erosion of the Silastic valve (2 patients, 7.1%), phthisis bulbi (2 patients, 7.1%). Mortality during long-term follow-up was high in our series. The complications of an underlying diabetes mellitus were the most common causes of death (15 out of 22 patients). The high mortality of patients subjected to valve implantation makes it difficult to interpret the results of long-term studies. However, the valve implant is still today an alternative surgical procedure for controlling IOP in eyes with neovascular glaucoma that have visual potential.

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The glaucomas in aphakia and pseudophakia

Cited by 52 publications

References 251 publications

Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery

The Effect of Hydroxyurea on Rabbit Subconjunctival Fibroblast Culture and Use of Hydroxyurea in Rabbits after Glaucoma Filtration Surgery

Long-Term Results of Krupin-Denver Valve Implants in Filtering Surgery for Neovascular Glaucoma

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