The Glandular Odontogenic Cyst: Clinicopathologic Features and Treatment of 14 Cases

Xia-nan, Qin; Li, Jinrong; Chen, Xinming; Long, Xing

doi:10.1016/j.joms.2004.12.016

Cited by 40 publications

(39 citation statements)

References 14 publications

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“…Although it appears, based on current knowledge and experience, that these MEC-like islands in the cyst wall likely have no clinical significance, this finding suggests at least the possibility that GOC and CMEC may be related or that CMEC may arise in GOC. The possible relationship of GOC and CMEC has been previously discussed by several investigators [21,[37][38][39][40]. However, definitive evidence in this regard will have to await further study.…”

Section: Discussionmentioning

confidence: 85%

“…Table 3 indicates that 8 cases of GOC were associated with an unerupted tooth (dentigerous relationship). This was an unexpected finding because the majority of reported cases of GOCs are not associated with unerupted teeth, as only 6 such cases have been previously reported [6,21,22,29,30]. Moreover, because some of the microscopic features of GOC are similar if not identical to metaplastic changes in dentigerous cysts, rendering a diagnosis of GOC for a cyst in a dentigerous relationship should be done with caution.…”

Section: Discussionmentioning

confidence: 86%

“…Many of these have been single case reports; however, several short series and detailed reviews of the literature have also been published [1,2,6,7,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Therefore, the GOC, though rare, is now relatively well known, especially among oral and head and neck pathologists.…”

Section: Discussionmentioning

confidence: 99%

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Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

129

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

129

172

View full text Add to dashboard Cite

show abstract

“…The clinical data including follow-up and recurrence are provided in Tables 1-3. 2,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Their distribution according to age in decades and gender is shown in Table 4. 14,15,18,19,[23][24][25][26]29 Their radiological data and the analysis are given in Tables 5 2,14,18-20,23-25 and 6.…”

Section: Systematic Reviewmentioning

confidence: 99%

Glandular odontogenic cyst: systematic review

MacDonald-Jankowski¹

2010

Dentomaxillofacial Radiology

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“…The literature, which consider the anterior region of the mandible [10,11,7] the most affected area, followed by the anterior region of the maxilla [12].…”

Section: Discussionmentioning

confidence: 99%

Glandular odontogenic cyst involving the posterior part of maxillary sinus, a rare entity

Rao

Kumar

2010

J. Maxillofac. Oral Surg.

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The Glandular Odontogenic Cyst: Clinicopathologic Features and Treatment of 14 Cases

Cited by 40 publications

References 14 publications

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Glandular odontogenic cyst: systematic review

Glandular odontogenic cyst involving the posterior part of maxillary sinus, a rare entity

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