The Gilded Clot: Review of Metal-Modulated Platelet Activation, Coagulation, and Fibrinolysis

Nielsen, Vance G.; Goff, Tanner; Hunsaker, Brent D.; Neves, Coulter D.

doi:10.3390/ijms24043302

Cited by 4 publications

(3 citation statements)

References 107 publications

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“…Calcium plays a key role in the regulation of platelet haemostasis [56]. Dietary calcium exerts protective effects on blood platelets and decreases platelet aggregation, even when the diet is enriched with saturated fatty acids [57] or sodium [58].…”

Section: Discussionmentioning

confidence: 99%

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Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects

Karolczak,

Guligowska,

Sołtysik

et al. 2024

Nutrients

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The aggregation of blood platelets is the pivotal step that leads to thrombosis. The risk of thrombotic events increases with age. Available data suggest that minerals taken with diet can affect the course of thrombosis. However, little is known about the relationship between platelet aggregability and mineral intake with diet among elderly people. Thus, we evaluated the associations between the reactivities of platelets to arachidonic acid, collagen or ADP and the estimated quantities of minerals consumed as a part of the daily diet in 246 subjects aged 60–65 years (124 men and 122 women). The found simple (not-adjusted) Spearman’s rank negative correlations are as follows: 1. arachidonate-dependent aggregation and the amounts of potassium, zinc, magnesium, phosphorus, iron, copper and manganese; 2. collagen-dependent aggregation and the amounts of potassium, phosphorus, iron and zinc; and 3. ADP-dependent aggregation and the amounts of potassium, phosphorus and zinc. The negative associations between ADP-dependent platelet reactivity and the amount of potassium, phosphorus and zinc and between collagen-dependent aggregability and the amount of phosphorus were also noted after adjusting for a bunch of cardiovascular risk factors. Overall, in older subjects, the intake of minerals with diet is negatively related to blood platelet reactivity, especially in response to ADP. Diet fortification with some minerals may possibly reduce the thrombotic risk among elderly patients.

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Section: Discussionmentioning

confidence: 99%

“…Little data are available on the effects of manganese on blood platelets; however, it appears that it may enhance platelet activation [56]. Nevertheless, its ability to either induce or hamper platelet aggregations has not been noted so far, despite the presence of the manganese-induced formation of pseudopodia [69].…”

Section: Discussionmentioning

confidence: 99%

Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects

Karolczak,

Guligowska,

Sołtysik

et al. 2024

Nutrients

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“…When studying the effect of cesium on platelet activity, plasma coagulation and fibrinolysis in vitro and in vivo, it was found that in the case of in vitro coagulation, CsCl had no significant effect on factor IX (FIX) activation compared to various monovalent salts; therefore, cesium does not affect FIX activity, and the only noticeable effect of cesium is the inhibition of ADP-mediated platelet activation (Nielsen et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

Ecological and toxicological features of the effect of stable cesium on striated muscle tissue (myocardium and skeletal muscles) of mammals

Yermishev

2023

Regul. Mech. Biosyst.

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Recently, the risks of radiation danger have significantly increased. This is connected with the start of a full-scale war against Ukraine and the seizure of the Zaporizhzhya NPP by the Russian Federation, which has the second most powerful arsenal of nuclear weapons in the world. The majority of studies devoted to the effect of radioactive radiation on the human body and animals absolutely do not take into account the ecotoxic effect of the carrier and a chemical element. At the same time, the body does not distinguish between radioactive and non-radioactive isotopes of chemical elements and interacts with them during exchange processes. The aim of the work was to study the influence of stable cesium on the microscopic structure of striated muscle tissue, both skeletal and cardiac ones. The results of our research revealed that intensive accumulation of cesium for 24 days occurred in all the examined organs and tissues. In fact, the most intensive accumulative process appeared to be in the heart by 214.9 times and by 695.3 times with skeletal muscles, with a simultaneous decrease in potassium content by 19.2% and 29.1%, respectively, compared to intact rats. We can talk about the presence of two mechanisms of action of cesium on tissues, including striated muscles: as an antagonist of potassium, which concerns the transport system of the latter and as a toxic element that initiates peroxide processes with subsequent modification of membranes and their potassium channels. Functional disturbances in the work of potassium channels of excitable tissues in the repolarization phase occur in the conditions of an increase in intracellular cesium in striated muscles. These disorders can proceed according to the type of acquired "potassium" channelopathies, which in the myocardium can manifest in the form of rhythm disorders, prolonged QT syndrome, etc. This leads to the appearance of significant violations of the histological structure of the examined tissues. Cesium has pronounced damaging effects on both skeletal and cardiac striated muscle tissue, with morphological changes in skeletal and cardiac striated muscle tissue being generally similar. Dystrophic changes in the nuclei and cytoplasm of cardiomyocytes and striated muscles, signs of impaired blood circulation in the microcirculatory channel with the formation of vascular wall edema, destruction of endothelial cells, various types of hemorrhages and lymphohistiocytic infiltration of the stroma of fibers are the consequences of the toxic effect of cesium on tissues. Thus, the results of changes in the histological structure of striated muscles under the action of cesium chloride obtained by us indicate a fairly high cytocidal activity of stable cesium.

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Association between urinary multiple metals and platelet-related parameters: A cross-sectional study in a metal-contaminated area of China

Zheng,

Yu,

et al. 2024

Environ Sci Pollut Res

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The Gilded Clot: Review of Metal-Modulated Platelet Activation, Coagulation, and Fibrinolysis

Cited by 4 publications

References 107 publications

Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects

Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects

Ecological and toxicological features of the effect of stable cesium on striated muscle tissue (myocardium and skeletal muscles) of mammals

Association between urinary multiple metals and platelet-related parameters: A cross-sectional study in a metal-contaminated area of China

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