The Germinal Center Precursor Cell is Surface μ and σ Positive

Seijen, H.G.; Bun, Judy C. A. M.; Wubbena, As; Löhlefink, K. G.

doi:10.1007/978-1-4684-5535-9_35

Cited by 13 publications

(5 citation statements)

References 8 publications

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“…This important problem could be further approached by determining whether the cells expressing germline V genes are enriched in the small fraction of proliferating cells in the /x-/i-compartment, as it would be predicted if they represent newly activated cells. Together with data indicating that/~+8 + B cells can be precursors of germinal center cells (46), this result suggests a scheme of peripheral B cell selection, as depicted in Fig. 5.…”

Section: Discuuionsupporting

confidence: 77%

“…Together with data indicating that/~+8 + B cells can be precursors of germinal center cells (46), this result suggests a scheme of peripheral B cell selection, as depicted in Fig. 5.…”

Section: Discuuionsupporting

confidence: 77%

“…5), i.e., first into the compartment of long-lived #+8 + cells and from there into the/z-8-compartment, the second step again depends on T cell help, whereas the selection of/z + 8 + cells may not require T cells. Sequential selection is known to occur since/z + 8 * cells can function as precursors of germinal center cells (46). This could simply represent a special case of parallel selection in the sense that the same antigens are involved in the sdection of #-8-and # + 8 + cells.…”

Section: Discuuionmentioning

confidence: 99%

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Natural occurrence and origin of somatically mutated memory B cells in mice.

Schittek

Rajewsky

1992

The Journal of Experimental Medicine

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SummaryWhile most murine peripheral B cells express germline-encoded antibodies of classes M and D (# +/~ + cells), small numbers of memory B cells expressing somatically mutated immunoglobulin G antibodies are generated upon T cell-dependent immunization. Analyzing the antibody repertoire of the #-~-B cell pool in unimmunized mice, we show that these cells express somatically mutated V. genes and that most of these genes derive from a set of germline V. genes dominantly expressed by #+8 + B cells. Thus, class-switched memory B cells are generated in the absence of intentional immunization, presumably in response to environmental antigens. These cells are either recruited from/~+/~+ B cells or selected from newly arising B cells in parallel to the latter, by the same antigens.

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Section: Discuuionsupporting

confidence: 77%

“…Together with data indicating that/~+8 + B cells can be precursors of germinal center cells (46), this result suggests a scheme of peripheral B cell selection, as depicted in Fig. 5.…”

Section: Discuuionsupporting

confidence: 77%

Section: Discuuionmentioning

confidence: 99%

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Natural occurrence and origin of somatically mutated memory B cells in mice.

Schittek

Rajewsky

1992

The Journal of Experimental Medicine

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“…More controversial is the phenotype of the GC precursor cells with respect to IgD expression. When B cells are fractionated into IgD+ vs IgD cells, the precursors are found in the IgD" population according to VonderHeide & Hunt (1988) and in the IgD^ population according to Seijen et al (1988). The results obtained from our laboratory suggest that, under normal conditions.…”

Section: Origin Of Germinal Center Cellsmentioning

confidence: 68%

The Path of Memory B‐Cell Development

Tsiagbe

Linton

Tiiorbecke

1992

Immunological Reviews

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“…In contrast, when J11D high cells or CD5 ϩ peritoneal B cells were transferred, few, if any, GC were generated (33). However, thoracic duct B cell transfer experiments in rats have generated contradictory conclusions as to whether GC precursor cells are sIgD ϩ or sIgD Ϫ (34,35). The present identification of tonsillar sIgM ϩ IgD ϩ CD38 ϩ B cells represents a parallel attempt in the human system to characterize GC founder cells.…”

Section: Discussionmentioning

confidence: 78%

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

Lebecque¹,

Bouteiller²,

Arpin³

et al. 1997

The Journal of Experimental Medicine

108

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B lymphocytes undergo affinity maturation of their antigen receptors within germinal centers. These anatomical structures develop in secondary lymphoid organs from the clonal expansion of a few antigen-specific founder B cells, whose isolation and characterization are reported here. Human germinal center founder cells express the naive B cell markers surface IgM and IgD as well as the germinal center B cell markers CD10 and CD38. They express low levels of Bcl-2, high levels of Fas, and undergo rapid apoptosis in culture. The smaller nonproliferating sIgM+IgD+CD38+ B cells displayed a lower level of somatic mutation in their immunoglobulin variable region genes compared with the large proliferating ones. Unmutated sIgM+IgD+CD38+ tonsillar B cells may thus represent germinal center founder cells in which the program for apoptotic cell death is triggered before the onset of somatic mutation, allowing the selection of the germline antibody repertoire at an early stage.

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The Germinal Center Precursor Cell is Surface μ and σ Positive

Cited by 13 publications

References 8 publications

Natural occurrence and origin of somatically mutated memory B cells in mice.

Natural occurrence and origin of somatically mutated memory B cells in mice.

The Path of Memory B‐Cell Development

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

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