The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

Polyphenols in edible plant leaves: an overview of their occurrence and health properties

“…205 Most studies on this promising plant focus on its composition rich in sesquiterpene lactones, which confer pharmacological functions such as anti-inflammatory, anticancer and antiparasitic effects. [206][207][208] However, information on its phenolic composition is limited, with a single study by Kerr et al, identifying a wide variety of glycosylated derivatives of quercetagetin, 6-hydroxykaempferol and 6-hydroxyluteolin (ESI Table S4 †). Further studies on the composition and biological properties of N. lobata polyphenols are required.…”

Isolation, Structure Determination of Sesquiterpenes from Neurolaena lobata and Their Antiproliferative, Cell Cycle Arrest-Inducing and Anti-Invasive Properties against Human Cervical Tumor Cells

“…Furthermore, the extract induced tumor suppressors, down-regulated the expression of oncogenes, inhibited cell proliferation and triggered the apoptosis of malignant cells [20]. Moreover, neurolenin B specifically decreased pro-carcinogenic NPM/ALK expression in ALK+ ALCL cells, and attenuated tumor intra/extravasation into the lymphatics [21]. Pharmacological investigation of lobatin B revealed that this compound also inhibited the expression of NPM/ALK, and in addition, the expression of JunB and PDGF-Rβ, and attenuated proliferation of ALCL cells by arresting them in late M phase [22].…”