The genus Leucas: A review on phytochemistry and pharmacological activities

Kumar, Sachin; Mittal, Amit; Kharkwal, Harsha; Jain, Shreyans K.; Goel, Bharat

doi:10.1016/j.fitote.2023.105492

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on published literatures, 41 phytoconstituents of L. aspera are obtained [19][20][21][22][23][24][25][26][27]. The structural data, molecular formula, and other needed data of these phytocompounds are retrieved from PubChem database in structure data format (SDF) (Table 3).…”

Section: Retrieval Of Phytocompounds Of L Asperamentioning

confidence: 99%

Phytochemical inhibitors from Leucas aspera against the target proteins induced by Trichophyton mentagrophytes using computational techniques

Giri,

Parida

2024

J Basic Microbiol

View full text Add to dashboard Cite

Dermatophytosis is a cutaneous infection that is able to degrade the keratinized tissues of the animal/human body, like skin, nails, and hair, causing chronic or subacute infection with the contact of some specific fungal strains. Trichophyton mentagrophytes are the most potential fungal pathogen causing dermatophytoses. The present study focuses on computationally based in silico antifungal activity of selected phytocompounds of Leucas aspera (Willd.) Link. against dermatophytic fungus, T. mentagrophytes. Validation and screening of derived phytocompounds is performed using Lipinski rule of five and toxicity test through Protox‐II. Five target genes involved in dermatophytosis, induced by T. mentagrophytes are retrieved from the UniProt Database, and the corresponding proteins such as glucan 1,3‐beta‐glucosidase ARB_02797, Probable class II chitinase ARB_00204, squalene monooxygenase, actin, and ubiquitin are selected for in silico study. Three‐dimensional structures of the target protein were computationally determined and validated through modeling tools and techniques due to the lack of validated protein structures in the database. Then, these proteins are used for in silico molecular docking through the AutoDock Vina tool to find out the promising phytocompounds. This study could be utilized in designing more effective drugs against T. mentagrophytes. Based on this work, a plant‐based natural alternative can be added to the treatment of dermatophytosis rather than synthetic supplements.

show abstract

Section: Retrieval Of Phytocompounds Of L Asperamentioning

confidence: 99%

Phytochemical inhibitors from Leucas aspera against the target proteins induced by Trichophyton mentagrophytes using computational techniques

Giri,

Parida

2024

J Basic Microbiol

View full text Add to dashboard Cite

show abstract

Phytochemical Profiling, FT-IR Spectroscopy, and Antioxidant Evaluation of Select Lamiaceae Species

Joselin,

Benila,

Brintha

et al. 2024

Intelligent Pharmacy

View full text Add to dashboard Cite

Evaluation of Analgesic and Anti-inflammatory activity of Ethanol extract from Leucas Lavandulaefolia Rees leaves

Amriani,

Muharni,

D. Carissa

et al. 2024

RJPT

View full text Add to dashboard Cite

Leucas lavandulaefolia has been traditionally used to treat wounds, rheumatism, migraines, diabetes, swelling and inflammation. This study aimed to determine the analgesic and anti-inflammatory activity of an ethanol extract of L. lavandulaefolia leaves. Analgesic activity was determined using the hot plate method, and anti-inflammatory activity based on carrageenan-induced rat paw oedema was determined using a plethysmometer. Each test used 25 male Wistar rats consisting of five treatment groups. Group I negative control was given Carboxymethyl Cellulose Sodium (Na CMC) 1%, Group II positive control was given sodium diclofenac dose 5.0 mg/kg Body weight (BW) for analgesic activity and aspirin dose 100 mg/kg BW for anti-inflammatory activity, and groups III–V (treatment groups) were given ethanol extract of L. lavandulaefolia leaves, with each dose at 200, 400 and 800 mg/kg BW. The results showed that the ethanol extract of L. lavandulaefolia leaves at a dose of 400 mg/kg BW had the highest analgesic activity percentage (22.85%) and no significant difference (p < 0.05) compared to the positive control (Diclofenac Na). Anti-inflammatory activity was highest at 800 mg/kg BW (percent inhibition 62.91%) and significantly different (p< 0.05) compared to the positive control (aspirin). This result indicates that the ethanol extract of L. lavandulaefolia leaves can be an alternative medicine for analgesics and inflammation.

show abstract

The genus Leucas: A review on phytochemistry and pharmacological activities

Cited by 3 publications

References 46 publications

Phytochemical inhibitors from Leucas aspera against the target proteins induced by Trichophyton mentagrophytes using computational techniques

Phytochemical inhibitors from Leucas aspera against the target proteins induced by Trichophyton mentagrophytes using computational techniques

Phytochemical Profiling, FT-IR Spectroscopy, and Antioxidant Evaluation of Select Lamiaceae Species

Evaluation of Analgesic and Anti-inflammatory activity of Ethanol extract from Leucas Lavandulaefolia Rees leaves

Contact Info

Product

Resources

About