The Genus Haemophilus

Fink, Doran L.; Geme, J. W. Saint

doi:10.1007/0-387-30746-x_40

Cited by 12 publications

(15 citation statements)

References 292 publications

(282 reference statements)

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“…H. parasuis SH0165 also possesses genes encoding phosphotransferase systems (PTS), which can be devoted to the uptake of other sugars, including glucose ( ptsHI-crr , HAPS0960–0958; ptsG , HAPS2092), fructose ( ptsEII , HAPS0193–0189), sucrose ( ptsB , HAPS1008) and mannose ( manXYZ , HAPS1732–1730). These confirmed genotypes support the previously observed biochemical patterns of sugar fermentation in H. parasuis [26].…”

Section: Resultssupporting

confidence: 91%

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Genomic Characterization of Haemophilus parasuis SH0165, a Highly Virulent Strain of Serovar 5 Prevalent in China

Zhao¹,

Yue²,

Zhou³

et al. 2011

PLoS ONE

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Haemophilus parasuis can be either a commensal bacterium of the porcine respiratory tract or an opportunistic pathogen causing Glässer's disease, a severe systemic disease that has led to significant economical losses in the pig industry worldwide. We determined the complete genomic sequence of H. parasuis SH0165, a highly virulent strain of serovar 5, which was isolated from a hog pen in North China. The single circular chromosome was 2,269,156 base pairs in length and contained 2,031 protein-coding genes. Together with the full spectrum of genes detected by the analysis of metabolic pathways, we confirmed that H. parasuis generates ATP via both fermentation and respiration, and possesses an intact TCA cycle for anabolism. In addition to possessing the complete pathway essential for the biosynthesis of heme, this pathogen was also found to be well-equipped with different iron acquisition systems, such as the TonB system and ABC-type transport complexes, to overcome iron limitation during infection and persistence. We identified a number of genes encoding potential virulence factors, such as type IV fimbriae and surface polysaccharides. Analysis of the genome confirmed that H. parasuis is naturally competent, as genes related to DNA uptake are present. A nine-mer DNA uptake signal sequence (ACAAGCGGT), identical to that found in Actinobacillus pleuropneumoniae and Mannheimia haemolytica, followed by similar downstream motifs, was identified in the SH0165 genome. Genomic and phylogenetic comparisons with other Pasteurellaceae species further indicated that H. parasuis was closely related to another swine pathogenic bacteria A. pleuropneumoniae. The comprehensive genetic analysis presented here provides a foundation for future research on the metabolism, natural competence and virulence of H. parasuis.

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Section: Resultssupporting

confidence: 91%

“…H. parasuis is a facultative anaerobe which possesses metabolic pathways of both fermentation and respiration for energy generation [26]. Two kinds of sugar transport systems were identified in the H. parasuis SH0165 genome.…”

Section: Resultsmentioning

confidence: 99%

Genomic Characterization of Haemophilus parasuis SH0165, a Highly Virulent Strain of Serovar 5 Prevalent in China

Zhao¹,

Yue²,

Zhou³

et al. 2011

PLoS ONE

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“…Interestingly, non-typeable H. influenza is a well-known pathogen that causes respiratory tract infections in COPD patients 32 , but the abundance of Haemophilus decreased with increasing pack-year values in the present study. Since members of the Haemophilus genus are common resident bacteria of the human airways 33 , further studies are required to explore the effect of smoking on specific species or strains of this genus. These observations suggest that smoking alters the abundance of specific members of the sputum microbiota, such as Veillonella , which can lead to an inflammatory condition or an environment in which pathogenic bacteria can thrive, and subsequently contribute to the development of smoking-related lung diseases.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans

Lim

Yoon

Rho

et al. 2016

Sci Rep

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Recent studies showing clear differences in the airway microbiota between healthy and diseased individuals shed light on the importance of the airway microbiota in health. Here, we report the associations of host genetics and lifestyles such as smoking, alcohol consumption, and physical activity with the composition of the sputum microbiota using 16S rRNA gene sequence data generated from 257 sputum samples of Korean twin-family cohort. By estimating the heritability of each microbial taxon, we found that several taxa, including Providencia and Bacteroides, were significantly influenced by host genetic factors. Smoking had the strongest effect on the overall microbial community structure among the tested lifestyle factors. The abundances of Veillonella and Megasphaera were higher in current-smokers, and increased with the pack-year value and the Fagerstrom Test of Nicotine Dependence (FTND) score. In contrast, Haemophilus decreased with the pack-year of smoking and the FTND score. Co-occurrence network analysis showed that the taxa were clustered according to the direction of associations with smoking, and that the taxa influenced by host genetics were found together. These results demonstrate that the relationships among sputum microbial taxa are closely associated with not only smoking but also host genetics.

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“…Most authors consider H. haemolyticus to be either nonpathogenic (2,4,7,18) or a rare pathogen (1). The latter assessment appears to be based on two reports of endocarditis from the early part of the 20th century (3,13); however, in neither case were requirements for the X and V factors reported, and thus, no species designation can be reliably made.…”

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confidence: 99%

An Invasive Haemophilus haemolyticus Isolate

et al. 2012

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FIG 1Neighbor-joining dendrogram of Haemophilus strains. The tree, rooted to E. coli strain MG1655, is based on concatenated adk, pgi, recA, infB, and 16S rRNA gene sequences, with bootstrap values of greater than 50% of 1,000 bootstraps indicated. Strains are genome-sequenced H. influenzae strains unless indicated otherwise. Hh, H. haemolyticus strains, including the type strain ATCC 33390 and five recently sequenced isolates (5); Hp, H. parainfluenzae strains. HI2028 is the strain identified in this report.

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The Genus Haemophilus

Cited by 12 publications

References 292 publications

Genomic Characterization of Haemophilus parasuis SH0165, a Highly Virulent Strain of Serovar 5 Prevalent in China

Genomic Characterization of Haemophilus parasuis SH0165, a Highly Virulent Strain of Serovar 5 Prevalent in China

Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans

An Invasive Haemophilus haemolyticus Isolate

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