The Genus Allium (Amaryllidaceae: Alloideae): Features, Phytoconstituents, and Mechanisms of Antidiabetic Potential of Allium cepa and Allium sativum

Sabiu, Saheed; Madende, Moses; Ajao, Abdulwakeel Ayokun-nun; Aladodo, Raliat Abimbola; Nurain, Ismaila Olarewaju; Ahmad, Jamiu Busari

doi:10.1016/b978-0-12-813822-9.00009-6

Cited by 21 publications

(15 citation statements)

References 79 publications

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“…Although the current conventional antidiabetic medicines are able to mitigate diabetes symptoms, they may also show some serious side effects such as hypoglycemia, edema, heart and liver abnormalities, and gastric and respiratory problems [ 98 ]. For this reason, scientists are looking at natural resources such as medicinal plants as alternative therapeutic agents against diabetes, as they are less harmful and have a lot of pharmacological value [ 98 , 99 ]. At present, many studies [ 97 , 98 , 100 ] are being performed on A. cepa to investigate its antidiabetic activities, and one of the experiments which was tested on diabetic rats showed that the aqueous extract of onions reduced blood glucose level in the same manner as that of glibenclamide, a conventional antidiabetic drug.…”

Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Chakraborty

Uddin

Zidan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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As Allium cepa is one of the most important condiment plants grown and consumed all over the world, various therapeutic and pharmacological effects of A. cepa were reviewed. Onion (Allium cepa) is a high dietary fiber-rich perennial herb that is placed under the family Amaryllidaceae. It contains high concentration of folic acid, vitamin B6, magnesium, calcium, potassium, and phosphorus as well as vitamins and minerals. It is widely used as an antimicrobial agent, but it showed anticancer, antidiabetic, antioxidant, antiplatelet, antihypertensive, and antidepressant effects and neuroprotective, anti-inflammatory, and antiparasitic effects and so on. It is said to have beneficial effects on the digestive, circulatory, and respiratory systems, as well as on the immune system. This review article was devoted to discussing many health benefits and traditional uses of onions in pharmacological perspectives, as well as the safety/toxicological profile. If more detailed research on this perennial herb is conducted, it will open the door to an infinite number of possibilities.

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Section: Therapeutic Potential Of Allium Cepamentioning

confidence: 99%

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Chakraborty

Uddin

Zidan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Extracts from AC have been shown to induce a variety of bioactivities, including anti-inflammatory, antioxidant, and anti-diabetic properties. [22,[90][91][92][93] S-methyl cysteine sulfoxide and S-allyl cysteine sulfoxide, which are found in the bulb, have been shown to have anti-diabetic properties [91]. Again many mechanisms can be responsible of the antidiabetic activity but secretagogue effect is the most relevant.…”

Section: Allium Cepa Linnmentioning

confidence: 99%

“…It has been discovered to have a wide range of biological effects, including anti-tumor activity, antibacterial action, immunomodulatory and antihyperglycemic activity, according to various scientific research investigations [95]. Alkaloids, flavonoids, cardiac glycosides, terpenes and steroids, resin, alliin, allicin, ajoene, diallyl sulfide, enzymes, B-vitamins, proteins, minerals, saponins, flavonoids, and so on, are all active phytochemicals found in raw garlic [22,93,94]. Garlic's biological activity in anti-diabetics has been proven to control the excretion of insulin from β-cells, promote glucose tolerance, and glycogen synthesis.…”

Section: Allium Sativum Linnmentioning

confidence: 99%

A Review on the Antidiabetic Potential of Medicinal Plants

Bushnak¹,

Hajj²,

Jaber³

2021

SJMH

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Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adverse effects. Medicinal plants, on the other hand, may serve as an alternate source of anti-diabetic agents. According to the World Health Organization, 80 % of the population in underdeveloped nations still relies on traditional medicines or folk medicines, which are largely made from plants, for disease prevention or treatment. For instance, anti- proliferative, anti-viral, anti-inflammatory and anti-hyperglycemic effects. In order to find a natural anti-diabetic source that comes with less side effects, several studies have been conducted. The aim of this work is to review these studies and highlight the potential of plants when it comes to their anti-diabetic effect.

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“…Also, contrary to the argument that appreciation of phytomedicine in Africa is linked to cultural and economic reasons, emerging evidence from clinical and experimental data strongly suggests their therapeutic efficacy against several diseases including diabetes, malaria, sickle-cell anaemia, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome (HIV/AIDS), cancer, dental disease, stroke, ulceration, Alzheimer's disease, Parkinson's disease, Huntington's disease, and microbial infections etc. [6,10,15,[18][19][20][21][22][23]. Furthermore, through appreciation of phytopharmacology, many African phytomedicines have become well known in the international markets and several of them including a Cameroonian plant (Ancistrocladus abbreivatus) with anti-HIV/AIDS potential, Elaeis guineensis, Agava sisalana, Tamarindus indica, Zingiber officinale, Capsicum annum, Phytostigma venenosum, Catharantus roseus, Rauvolfia vomitoria, Chrysanthemum cinerariifolium, and Prunus africana etc.…”

Section: Benefits and Direction Of Phytopharmacology In The African Smentioning

confidence: 99%

Phytodentistry in Africa: prospects for head and neck cancers

et al. 2021

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Background Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Although, significant milestones have been achieved in the molecular dentistry field in the past decade, there remains a dearth of application of phytopharmacological innovation in personalized and targeted therapies for dental diseases. Main body From time immemorial, plant products have long been an integral aspect of dental practice ranging from chewing sticks/herbal kinds of toothpaste to dental/impression materials. The current era of precision medicine seeks to apply a multipronged molecular and bio-computational approaches to solve fundamental medical problems that have hitherto remained difficult. Remarkable changes in the molecular/omics era, have transformed empirical therapies into personalized/individualized ones. Furthermore, the combinatorial application and the widespread introduction of high-throughput molecular tools such as pharmacogenomics, phytopharmacology, metabolomics, mathematical modelling, and genetic engineering inter alia, has tremendously improved the diagnostic and therapeutic landscape of medicine. Additionally, the variable molecular epidemiology of diseases among different population and emerging molecular evidence warrants the use of customized novel theranostic techniques. Unfortunately, the footprint of such emerging application is sparse in dental diseases such as maxillofacial cancers. Conclusion Hence, this review seeks to evaluate the potential application of phytopharmacological approaches to head and neck cancers in a resource-limited environment, such as Africa.

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The Genus Allium (Amaryllidaceae: Alloideae): Features, Phytoconstituents, and Mechanisms of Antidiabetic Potential of Allium cepa and Allium sativum

Cited by 21 publications

References 79 publications

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

A Review on the Antidiabetic Potential of Medicinal Plants

Phytodentistry in Africa: prospects for head and neck cancers

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