The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication

Geyikoğlu, Fatime; Türkez, Hasan; Bakır, Tülay Özhan; Çiçek, Mustafa

doi:10.1177/0748233712440140

Cited by 63 publications

(49 citation statements)

References 61 publications

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“…Geyikoĝlu et al (2013) conducted a liver MN assay in adult male Sprague-Dawley rats given daily ip injections of AlCl 3 at 5 mg/kg-day for 10 weeks. A control group of six rats received daily ip injections of saline.…”

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

330

201

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Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

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Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

330

201

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“…Numerous studies have suggested that hesperidin shows its neuroprotective action in cerebral ischemia reperfusion injury, hypoxia-ischemic brain injury, Huntington disease, cisplatin-induced neurotoxicity, stroke, pentylenetetrazole (PTZ)-induced kindling, and associated cognitive dysfunction [20][21][22][23][24]. On the other hand, [1,4] dioxin-6-yl] chroman-4-one] is a polyphenolic flavonoid and the chief component of silymarin derived from the herb milk thistle (Silybum marianum). It has been reported to have potent antioxidant and antiinflammatory properties [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately, 7600 μg/day aluminum is consumed by human through different routes like food, drinking water, soil, and dust ingestion [1]. Several experimental studies show that aluminum compounds are associated with a wide range of pathological conditions such as Alzheimer's disease, reproductive toxicity, cytoskeletal pathologies, microcytic anemia, osteomalacia, dialysis encephalopathy, and hepato-renotoxicity [2][3][4][5]. Prolonged exposure to aluminum is most prominently associated with neurotoxic events [6].…”

Section: Introductionmentioning

confidence: 99%

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Jangra

Kasbe

Pandey

et al. 2015

Biol Trace Elem Res

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Mounting evidence suggests that long-term aluminum exposure results in severe toxic effects, including neurobehavioral and neurochemical anomalies. The present study was performed to examine the neuroprotective potential of hesperidin and silibinin against aluminum chloride (AlCl3)-induced neurotoxicity in mice. AlCl3 (100 mg/kg/day) was injected daily through oral gavage for 42 days. Concomitantly, hesperidin (50 and 100 mg/kg/day, p.o.) and silibinin (100 and 200 mg/kg/day, p.o.) was administered for 42 days in different groups. The extent of cognitive impairment was assessed by Morris water maze and novel object recognition test on the 43rd day. Neurotoxicity was assessed by measuring oxido-nitrosative stress and proinflammatory cytokines in the hippocampus of mice. Six weeks treatment with AlCl3 caused cognitive impairment as indicated by an increase in the retention latency time and reduction in the percentage of recognition index. AlCl3-treated group showed oxido-nitrosative stress as indicated by increase in the level of lipid peroxidation, nitrite and depleted reduced glutathione, catalase activity in the hippocampus. Moreover, the chronic AlCl3 administration raised the proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α) level and increased acetylcholinesterase activity and reduced the BDNF content in the hippocampus of AlCl3-treated animals. However, chronic treatment with hesperidin and silibinin at higher doses significantly ameliorated the AlCl3-induced cognitive impairment and hippocampal biochemical anomalies. The present study clearly indicated that hesperidin and silibinin exert neuroprotective effects against AlCl3-induced cognitive impairment and neurochemical changes. Amelioration of cognitive impairment may be attributed to the impediment of oxido-nitrosative stress and inflammation in the hippocampus.

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“…To date, the main known toxicological effects of aluminium included anaemia (7)(8)(9), neurodegenerative disorders such as Alzheimer disease and dementia (10)(11)(12)(13)(14)(15)(16)(17), amyotrophic lateral sclerosis (18)(19)(20), hepatotoxicity (21)(22)(23), or diverse reproductive disorders (24)(25)(26)(27)(28)(29)(30). The toxic effects associated with aluminium are due, in most situations, to generation of reactive oxygen species (ROS) (31,32), conducing to cellular lipidic proteinic and/or DNA oxidative deterioration (33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

The consequences of aluminium intake on reproductive function in male rats:a three-generation study

Муселин¹,

Cristina²,

Igna³

et al. 2016

Turk J Med Sci

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The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication

Cited by 63 publications

References 61 publications

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

The consequences of aluminium intake on reproductive function in male rats:a three-generation study

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