“…Hitherto a large number of C1q domain containing protein (C1qDC) genes have been documented from numerous phylogenetically diverse organisms, such as 52 C1qDC gene models in zebrafish (Mei and Gui, 2008), 32 in humans (Tang et al, 2005), 29 in mice (Yuzaki, 2008), 75 in Branchiostoma floridae (Huang et al, 2008), and 7 in the Strongylocentrotus purpuratus (Hibino et al, 2006). Recently, the massive expansion of C1qDC in many mollusks have been reported, such as 524 in Mytilus edulis (Philipp et al, 2012), 232 in M. galloprovincialis (Gerdol et al, 2011), and in 337 in Crassostrea gigas (Gerdol et al, 2015). The increased expression of C1qDC transcripts were linked to the infections of Gram-positive, Gram-negative bacteria and cell wall components (lipopolysaccharide, glucan and peptidoglycan) (Adema et al, 2010;H.H.…”