The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clones

D'Amato, Felicetta; Rouli, Laetitia; Edouard, Sophie; Tyczka, Judith; Million, Matthieu; Robert, Caroline; Nguyen, Thi Tien; Raoult, Didier

doi:10.1016/j.cimid.2014.08.003

Cited by 30 publications

(30 citation statements)

References 37 publications

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“…Since 2003, six new whole genomes of C. burnetii have become available in GenBank (142)(143)(144). Sixteen incomplete genomes can also be found (27,47,(145)(146)(147)(148)(149)(150).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

“…Therefore, we sequenced the Z3055 strain isolated from a German ewe, which belonged to the same genotype (MST 33) as NL-Limburg (150). Compared with other C. burnetii genomes available in GenBank, we found a high proportion of mutations in genes coding for ankyrin repeat domain proteins, membrane proteins, and proteins involved in translation and transcription (143). Thus, we hypothesized that these mutations may have changed surface antigens, as in the case of influenza virus.…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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“…Since 2003, six new whole genomes of C. burnetii have become available in GenBank (142)(143)(144). Sixteen incomplete genomes can also be found (27,47,(145)(146)(147)(148)(149)(150).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…Parmi ceux-ci on compte le génome du clone Z3055 lié à l'épidémie des Pays-Bas qui a ensuite été complètement séquencé (D'Amato et al 2014c). Karlsson et collaborateurs ont séquencé 8 génomes supplémentaires (Karlsson et al 2014) dont la souche Namibia, isolée en 1991 d'un avortement caprin en Namibie, qui a également été complètement séquencée (Walter et al 2014a).…”

Section: Génomiqueunclassified

Coxiella burnetii, agent de la fièvre Q

Boarbi¹,

Frétin²,

Mori³

2016

Can. J. Microbiol.

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Résumé : La fièvre Q est une zoonose de répartition mondiale excepté la Nouvelle-Zélande. Elle est due à une bactérie intracellulaire : Coxiella burnetii. Cette infection passe souvent inaperçue car la manifestation principale de la forme aiguë de la maladie est un syndrome pseudogrippal spontanément résolutif. C'est l'épidémie qui a eu lieu aux Pays-Bas qui a attiré l'attention sur cette maladie qui était moins étudiée auparavant. Cette synthèse résume la description de la bactérie (taxonomie, cycle intracellulaire et génomique) mais également la maladie (description, diagnostic, pathogénie et épidémiologie). Enfin, la vaccination de l'humain et des animaux est également analysée. Mots-clés : Coxiella burnetii, fièvre Q, épidémiologie, description, génomique.Abstract: Q fever is a zoonosis of worldwide distribution with the exception of New Zealand. It is caused by an intracellular bacterium, Coxiella burnetii. The disease often goes underdiagnosed because the main manifestation of its acute form is a general self-limiting flu-like syndrome. The Dutch epidemics renewed attention to this disease, which was less considered before. This review summarizes the description of C. burnetii (taxonomy, intracellular cycle, and genome) and Q fever disease (description, diagnosis, epidemiology, and pathogenesis). Finally, vaccination in humans and animals is also considered.

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“…Comparative analysis of these genomes highlighted their diversity regarding pseudogene content and number of insertion sequence elements, possibly explaining their biological differences (Beare et al 2009). Recently, along with the development of powerful sequencing platforms, the numbers of sequenced genomes have blossomed to more than 40, 26 being publically available (D'Amato et al 2014, Karlsson et al 2014, SidiBoumedine et al 2014, Walter et al 2014, Hammerl et al 2015. Despite the large number of genome records for C. burnetii since 2003, only nine genomes are fully sequenced and annotated as closed circular genomes, the remainder are available as fragmented scaffolds, contigs, or whole genome shotgun sequences in various genome databases (www .patricbrc.org/portal/portal/patric/Home, www.ncbi.nlm.nih .gov/genome/genomes/543).…”

Section: Genome and Genetic Characterizationmentioning

confidence: 99%