The Genital Mycoplasmas

McCormack, William M.; Braun, Peter; Lee, Yhu-Hsiung; Klein, Jerome O.; Kass, Edward H.

doi:10.1056/nejm197301112880206

Cited by 178 publications

(43 citation statements)

References 89 publications

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“…Among men who had had intercourse with 5 women or less during their lifetime, U. urealyticum was recovered from 22 (92%) of 24 with chlamydia-negative NGU and 3 (23%) of 13 with no urethritis (P < 0.002) and 8 (50%) of 16 with chlamydiapositive NGU (P < 0.01). It was also possible to consecutively match, in the order that they were admitted to the study, 20 chlamydia-negative NGU patients with 20 patients with no urethritis exactly for total number of lifetime sex contacts and for age +2 yr. U. urealyticum was recovered from 17 of 20 chlamydia-negative NGU patients and from 9 of 20 matched controls with no urethritis (P < 0.02).…”

Section: Methodsmentioning

confidence: 99%

“…The etiology of chlamydia-negative NGU has not been elucidated by previous qualitative analysis of the urethral flora of men with and without NGU (1), but Ureaplasma urealyticuim (8) and Hemophiltus vaginalis (9, 10) have been suspected to be possible causes of NGU. Previous studies indicate 22-90% of NGU cases respond to sulfonamide therapy (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.

Bowie¹,

Wang²,

Alexander³

et al. 1977

J. Clin. Invest.

181

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.

Bowie¹,

Wang²,

Alexander³

et al. 1977

J. Clin. Invest.

181

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“…These results suggest that rosaramicin may be useful for the treatment of U. urealyticum infections.The most common causes of urethritis are Neisseria gonorrhoeae and Chlamydia trachomatis; however, the etiological role of Ureaplasma urealyticum in this infection has been controversial (7,10 …”

mentioning

confidence: 99%

“…The most common causes of urethritis are Neisseria gonorrhoeae and Chlamydia trachomatis; however, the etiological role of Ureaplasma urealyticum in this infection has been controversial (7,10). Definite conclusions regarding the pathogenicity of this organism have been hampered by the frequency of urethral colonization by U. urealyticum of asymptomatic controls matched for sexcual activity with men with urethritis.…”

mentioning

confidence: 99%

In Vitro Susceptibility of Ureaplasma urealyticum to Rosaramicin

Smith

1979

Antimicrob Agents Chemother

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Thirty-two clinical isolates of Ureaplasma urealyticum were inhibited by 0.036 jig of rosaramicin per ml, whereas 25 (78%) and 13 (41%) of the strains were inhibited by this concentration of minocycline and tetracycline, respectively. These results suggest that rosaramicin may be useful for the treatment of U. urealyticum infections.The most common causes of urethritis are Neisseria gonorrhoeae and Chlamydia trachomatis; however, the etiological role of Ureaplasma urealyticum in this infection has been controversial (7,10

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“…McCormack also found a higher prevalence of U. urealyticum in 54% of students with abnormal urogenital findings (McCormack, 2001). The low detection of M. hominis may be due to the fact that there were no women with bacterial vaginitis in our study group.…”

Section: Discussionmentioning

confidence: 50%

Prevalence of Mycoplasma hominis and Ureaplasma urealyticum among women with unexplained infertility, with and without vaginitis and cervicitis

Jafar¹,

Robeena²

2011

Afr. J. Microbiol. Res.

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The main objective of this study was to find the incidence of urogenital mycoplasma such as Mycoplasma hominis and Ureaplasma urealyticum among patients with history of infertility of unexplained origin and to ascertain their implications in non specific cervicitis and non specific vaginitis. The total number of (n = 337) female patients with history of un-explained vaginitis and cervicitis were screened to observe the prevalence of urogenital mycoplasmas in the disease. Both the high vaginal swabs (HVS) and mid-stream urine were cultured on the liquid media, U-9, and the solid differential mycoplasma agar A-7. The differentiation 0f the implicated organisms were made on the basis of metabolic characteristics of the species. Amongst the total (n = 337) samples, the n = 89 (26.40%) were positive for M. hominis whereas n= 162 (48.07%) isolates determined the U. urealyticum. Upon the outcomes of disease, the cases of non-specific cervicitis yielded the growth of M. hominis and Ureaplasma urealyticum as 32.58% and 59.87% respectively, whereas, among patients of non specific vaginitis, the M. hominis and U. urealyticum were isolated in ratio of 59.55 and 21.60% likewise. From the obtained data in both categories, no solid and direct etiological evidence could be linked to a definite disease outcome of infertility. However, it is certain that these mycoplasmas do cause the urogenital problems as indicated by percents of isolates obtained exclusively. Consequently, after the infection, these organisms could possibly associate for their role in the reproductive failure due to the resulting pathological complications in the urogenital tract of women.

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The Genital Mycoplasmas

Cited by 178 publications

References 89 publications

Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.

Etiology of nongonococcal urethritis. Evidence for Chlamydia trachomatis and Ureaplasma urealyticum.

In Vitro Susceptibility of Ureaplasma urealyticum to Rosaramicin

Prevalence of Mycoplasma hominis and Ureaplasma urealyticum among women with unexplained infertility, with and without vaginitis and cervicitis

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