The Genetics of Suicide: A Critical Review of Molecular Studies

Brezo, Jelena; Klempan, Timothy A.; Turecki, Gustavo

doi:10.1016/j.psc.2008.01.008

Cited by 122 publications

(80 citation statements)

References 186 publications

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“…However, we did observe direct genetic associations with SA. Accumulated observations in our sample and others shows that HPA axis regulatory genes, as well as other genes, are directly associated with suicidal behavior (Wasserman et al, 2007;Brezo et al, 2008), in line with a diversified genetic etiology. It is noteworthy that we have previously observed genetic associations (in the currently used trio data set) of common SNPs in neural conduction and neurotransmitter release (Wasserman et al, 2005), monoaminergic signaling (Wasserman et al, 2007;BenEfraim et al, 2012), and glutamatergic signaling genes .…”

Section: Avpr1b G â E Vs Genetic Associationssupporting

confidence: 77%

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Ben-Efraim

Wasserman

et al. 2013

Neuropsychopharmacol

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The cortisol response to psychosocial stress may become dysregulated in stress-related disorders. It is potentiated by pituitary secretion of adrenocorticotropic hormone (ACTH), which is, in part, regulated by arginine vasopressin receptor-1B (AVPR1B). AVPR1B variants were previously reported to associate with mood and anxiety disorders. This study aims, for the first time, to investigate association of AVPR1B genetic variants with mood and anxiety outcomes in suicidal behavior.Using a family-based study design of 660 complete nuclear family trios with offspring who have made a suicide attempt (SA), we tested the direct association and linkage of AVPR1B single nucleotide polymorphisms (SNPs) with SA, as well as with depression and anxiety in SA. Main findings were the association and linkage of AVPR1B exon 1 SNP rs33990840 and a major 6-SNP haplotype representative of all common AVPR1B-SNPs, on the outcome of high Beck Depression Inventory scores in SA. By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. An exploratory screen of interactions between AVPR1B and CRHR1 (corticotropin-releasing hormone receptor-1), the principal pituitary regulator of ACTH secretion, showed no support for gene-gene interactions on the studied outcomes. The results suggest that AVPR1B genetic variation, eg, non-synonymous SNP rs33990840 mediating putative consequences on ligand binding, has a role in SA etiology characterized by elevated depression symptoms, without involving AVPR1B-moderation of SLEs.

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Section: Avpr1b G â E Vs Genetic Associationssupporting

confidence: 77%

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Ben-Efraim

Wasserman

et al. 2013

Neuropsychopharmacol

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“…Otros factores de riesgo para el suicidio incluyen el estado civil, estar desempleado, historia de maltrato, abuso infantil y enfermedades neurológica. Sin embargo, los eventos socioculturales no explican en su totalidad la conducta suicida por lo que se sugiere que factores biológicos, como la vulnerabilidad genética pudieran estar participando en la determinación de la conducta suicida, debido a esto, mediante estudios de epidemiología genética se ha sugerido que existe un factor genético asociado a la conducta suicida (Brezo, et al, 2008).…”

Section: Factores De Riesgounclassified

“…Kim et al (2005) observaron que los familiares de los suicidas presentaron hasta 10 veces mayor riesgo de suicidio y atentados suicidas, que en el grupo control. Este riesgo familiar se ha mostrado en diversos trabajos (Brezo et al, 2008;Fu et al, 2002;Kim et al, 2005), destaca un estudio realizado en población sueca, en individuos que fueron hospitalizados por presentar intentos de suicidio entre 1968y 1980(Mittendorfer-Rutz, Rasmussen, & Wasserman, 2008, y observaron que el riesgo de suicidio aumenta entre familiares con intentos suicidas este se presenta a edad temprana principalmente en el género masculino.…”

Section: Neurobiología De La Conducta Suicidaunclassified

“…En él intervienen tanto los pensamientos suicidas (ideación suicida) como el acto suicida en sí. En el suicida se detectan: a) los actos fatales o suicidio consumado (Brezo, Klempan, & Turecki, 2008;Mann et al, 2008;Mann, Waternaux, Haas, & Malone, 1999); b) los intentos de suicidio altamente letales aunque fallidos, con intención y planeación del suicidio (Mann, et al, 2008;Mann, et al, 1999); y c) los intentos de baja letalidad, generalmente asociados a una situación psicosocial crítica (Beck, Weissman, Lester, & Trexler, 1976;Courtet, Gottesman, Jollant, & Gould, 2011).…”

Section: Introductionunclassified

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Genes, the serotonergic system and suicidal behavior

Tovilla‐Zárate

Mendoza

2012

Int. j. psychol. res.

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The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.Key Words: Suicide; serotonin; genetics; polymorphism; association studies . RESUMENLa conducta suicida es un problema de salud mental en el mundo. El estudio de la conducta suicida toma interés dado que en los años recientes, cerca del 50% de la población entre 14 y 19 años de edad presentan ideación suicida y en la población general se observa un aumento hasta del 150% en la conducta suicida. Estudios de epidemiología genética muestran que los genes pueden estar asociados a la conducta suicida. Recientemente se ha propuesto que los genes involucrados en la llamada vía serotoninérgica están participando, ya que evidencia neuroquímica demuestran alteraciones a diferentes niveles. Sin embargo, en población latina son pocos los estudios que evalúen el papel de los genes para generar estas condiciones. En este trabajo, se presenta una revisión de los principales genes que participan en la vía serotoninérgica y presenta evidencia de la participación de esos en la conducta suicida.Palabras Clave: Suicidio, Serotonina, Genética, polimorfismos, Estudios de asociación . ________________________ Recibido

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“…16,17 Genetic studies have also tried to build a solid theoretical basis on gene-related aspects of suicide. Particular attention has been given to the gene encoding for tryptophan hydroxylase and monoamine oxidase A; 18,19 for a review see Brezo et al 20 Early-life adversities (ELA) are considered as important lifetime risks for suicidal behaviour. In fact, recent research has suggested a link between poor parent-child attachment and maladjustment in the parental role on one side, and childhood abuse on the other.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory markers and suicidal attempts in depressed patients: A review

Marini

Vellante

Matarazzo

et al. 2016

Int J Immunopathol Pharmacol

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Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.

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The Genetics of Suicide: A Critical Review of Molecular Studies

Cited by 122 publications

References 186 publications

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Genes, the serotonergic system and suicidal behavior

Inflammatory markers and suicidal attempts in depressed patients: A review

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