The Genetics of Psoriasis 2001

Elder, James T.; Nair, Rajan P.; Henseler, Tilo; Jenisch, Stefan; Stuart, Philip E.; Chia, Nicholas V.C.; Christophers, Enno; Voorhees, John J.

doi:10.1001/archderm.137.11.1447

Cited by 194 publications

(164 citation statements)

References 51 publications

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“…This locus accounts for 50% of the genetic variance in psoriasis [14]. Patients with early-onset psoriasis exhibit HLA-Cw6 allele variability in the HLA-C locus, compared to patients with sporadic, late-onset psoriasis [7, 15]. The presence of HLA-Cw6 has been shown to affect different aspects of psoriasis, including genetic susceptibility, clinical manifestation, comorbidity, and treatment efficacy [16].…”

Section: Resultsmentioning

confidence: 99%

“…The skin epidermis has been identified as a key player in the early pathogenic steps of psoriasis by contributing to the activation of the immune response as well as the recruitment of inflammatory and endothelial cells [6]. Moreover, the elucidation of the major influence exerted by the psoriasis susceptibility gene has allowed for a fine tuning of the understanding of the pathophysiology of psoriasis [7-9]. …”

Section: Introductionmentioning

confidence: 99%

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Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease – a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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“…Based on twin studies, the heritability of psoriasis has been estimated to be 60%-90%, which is among the highest of all multifactorial genetic diseases. 7,8 Concordance rates as high as 70% have been reported among monozygotic twins, versus 12%-30% in dizygotic twins. 9 Family studies indicate that if both parents have psoriasis, the offspring have a 50% chance of developing the disease.…”

Section: Genetic Basismentioning

confidence: 99%

Psoriasis: epidemiology, natural history, and differential diagnosis

Basko-Plluska¹,

Petronic‐Rosic²

2012

PTT

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Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genomewide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immunemediated, inflammatory disorders.

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“…Type II psoriasis is characterized by a late onset and its heritability is not entirely clear. Environmental factors that are likely to influence psoriasis development are streptococcal infections and stress or trauma (Koebner reaction to injury) (11,12).…”

mentioning

confidence: 99%

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

Keß

Lindqvist

Peters

et al. 2006

The Journal of Immunology

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Psoriasis is a frequently occurring inflammatory skin disease characterized by thickened erythematous skin that is covered with silvery scales. It is a complex genetic disease with both heritable and environmental factors contributing to onset and severity. The CD18 hypomorphic PL/J mouse reveals reduced expression of the common chain of β2 integrins (CD11/CD18) and spontaneously develops a skin disease that closely resembles human psoriasis. In contrast, CD18 hypomorphic C57BL/6J mice do not demonstrate this phenotype. In this study, we have performed a genome-wide scan to identify loci involved in psoriasiform dermatitis under the condition of low CD18 expression. Backcross analysis of a segregating cross between susceptible CD18 hypomorphic PL/J mice and the resistant CD18 hypomorphic C57BL/6J strain was performed. A genome-wide linkage analysis of 94 phenotypically extreme mice of the backcross was undertaken. Thereafter, a complementary analysis of the regions of interest from the genome-wide screen was done using higher marker density and further mice. We found two loci on chromosome 10 that were significantly linked to the disease and interacted in an additive fashion in its development. In addition, a locus on chromosome 6 that promoted earlier onset of the disease was identified in the most severely affected mice. For the first time, we have identified genetic regions associated with psoriasis in a mouse model resembling human psoriasis. The identification of gene regions associated with psoriasis in this mouse model might contribute to the understanding of genetic causes of psoriasis in patients and pathological mechanisms involved in development of disease.

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The Genetics of Psoriasis 2001

Cited by 194 publications

References 51 publications

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

Psoriasis: epidemiology, natural history, and differential diagnosis

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

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