2001
DOI: 10.1001/archderm.137.11.1447
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The Genetics of Psoriasis 2001

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Cited by 195 publications
(165 citation statements)
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References 51 publications
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“…This locus accounts for 50% of the genetic variance in psoriasis [14]. Patients with early-onset psoriasis exhibit HLA-Cw6 allele variability in the HLA-C locus, compared to patients with sporadic, late-onset psoriasis [7, 15]. The presence of HLA-Cw6 has been shown to affect different aspects of psoriasis, including genetic susceptibility, clinical manifestation, comorbidity, and treatment efficacy [16].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…This locus accounts for 50% of the genetic variance in psoriasis [14]. Patients with early-onset psoriasis exhibit HLA-Cw6 allele variability in the HLA-C locus, compared to patients with sporadic, late-onset psoriasis [7, 15]. The presence of HLA-Cw6 has been shown to affect different aspects of psoriasis, including genetic susceptibility, clinical manifestation, comorbidity, and treatment efficacy [16].…”
Section: Resultsmentioning
confidence: 99%
“…The skin epidermis has been identified as a key player in the early pathogenic steps of psoriasis by contributing to the activation of the immune response as well as the recruitment of inflammatory and endothelial cells [6]. Moreover, the elucidation of the major influence exerted by the psoriasis susceptibility gene has allowed for a fine tuning of the understanding of the pathophysiology of psoriasis [7-9]. …”
Section: Introductionmentioning
confidence: 99%
“…Based on twin studies, the heritability of psoriasis has been estimated to be 60%-90%, which is among the highest of all multifactorial genetic diseases. 7,8 Concordance rates as high as 70% have been reported among monozygotic twins, versus 12%-30% in dizygotic twins. 9 Family studies indicate that if both parents have psoriasis, the offspring have a 50% chance of developing the disease.…”
Section: Genetic Basismentioning
confidence: 99%
“…Type II psoriasis is characterized by a late onset and its heritability is not entirely clear. Environmental factors that are likely to influence psoriasis development are streptococcal infections and stress or trauma (Koebner reaction to injury) (11,12).…”
mentioning
confidence: 99%