The genetics of Kawasaki disease

Onouchi, Yoshihiro

doi:10.1111/1756-185x.13218

Cited by 102 publications

(74 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,8,[10][11][12][23][24][25]29 The etiology of KD onset is thought to involve gene-environmental interactions 7,37 and patients affected at ages younger or older than the peak age of onset may also have characteristic genetic factors. 37 More recently, an age-stratified genome-wide association study targeting both Korean and Japanese populations suspected a rare non-synonymous SNP (rs4365796) in the lymphoid enhancer binding factor 1 gene to be a susceptibility gene to specifically affect KD patients younger than 6 months of age. 38 Interestingly, Biezeveld et al suggested that polymorphisms in the mannose-binding lectin gene are one of the determinants of age-defined risks of CAAs in KD patients, being protective in infants but potentially harmful in patients aged >1 year.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism of sex-related risks for developing CAAs, as well as the susceptibility to KD, remains unresolved. 7,37 Previous epidemiological studies reported that males were vulnerable in terms of their susceptibility to KD onset [7][8][9]20 and the development of CAAs. 15,[17][18][19][20] More recently found sex-specific genetic variants involved in KD pathogenesis (eg, FCGR2A His167Arg polymorphism) may provide new insight into KD susceptibility.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–2017

Kitano

Takeuchi

Suenaga

et al. 2021

Journal of Epidemiology

View full text Add to dashboard Cite

Background: Epidemiological studies show a U-shaped tendency in Kawasaki disease (KD)-related coronary artery abnormalities (CAAs) across age categories. Since studies suggest seasonal variations in KD onset, this study aimed to clarify the epidemiologic features of CAAs, considering the seasons of KD-occurrence. Methods: We analyzed 2,106 (males = 1,215, females = 891) consecutive KD cases from October 1999 through September 2017 using our electronic database of annual surveys, targeting all hospitals with pediatric departments across Wakayama, Japan. The primary outcome was the presence=absence of CAAs measured by echocardiography 1 month after KD onset. Odds ratios (ORs) and 95% confidence intervals (CIs) of combined patient age and sex for CAAs were calculated using logistic regression models adjusted for four seasons. Results: The median age was 25 (range, 1-212) months. The proportion of males decreased with increasing age. The youngest age group (<6 months) showed an inverse summer=autumn to winter=spring ratio (>1.0) in KD-occurrence. CAAs were observed in 2.8% of cases (males = 3.4%, females = 2.1%), which significantly lessened in summer than in other seasons. Moreover, 50% (n = 4=8) of cases with giant aneurysms experienced KD in autumn. Adjusted ORs for CAAs among males aged ≥60 months (3.0; 95%, CI 1.2-7.5) and females aged <6 months (3.6; 95%, CI 1.1-11.8) were significantly higher than those among males aged 12-35 months. Conclusions: Cumulative 18-year data of consecutive KD cases from one area suggest the influence of interactions between patient age and sex on the development of KD-related CAAs. The season of KD-occurrence may reflect the diversity of agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–2017

Kitano

Takeuchi

Suenaga

et al. 2021

Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…Various susceptibility genes have been identified to have association with KD. These includes inositol 1,4,5-trisphosphate 3-kinase C (ITPKC), Caspase-3 calcium release-activated calcium modulator 1 (ORAI1), and CD 40 [19][20][21]. Knowledge about these susceptibility genes may provide new insights in etiopathogenesis of KD.…”

Section: Geneticsmentioning

confidence: 99%

Kawasaki Disease

Pilania¹,

Singh²

2019

Periodic and Non-Periodic Fevers

View full text Add to dashboard Cite

Kawasaki disease (KD) is an acute and usually self-limiting medium vessel vasculitis of childhood that has a predilection to involve the coronary arteries. It is characterized by the sequential appearance of a constellation of clinical features [1]. However, none of these clinical findings is, in itself, pathognomonic of KD. Many of these clinical features can, in fact, be seen in other common febrile illnesses of children. It is for this reason that the diagnosis of KD is often considered to be a clinical challenge [2]. Approximately 15-25% of untreated patients may go on develop coronary artery abnormalities (CAAs) and this remains the major cause of morbidity, and occasional mortality, in KD [3].

show abstract

“…1 Epidemiologic clues have provided valuable insights into the nature of the disease including the genetic predisposition that underlies susceptibility. 2 The elucidation of the distinct seasonality, the lack of documented person-to-person spread, and the spatiotemporal clustering of cases all suggest a fluctuating exposure that triggers the disease. 3 Clinical features of the illness, including mucosal inflammation of the lips, tongue, and upper airway coupled with cervical lymphadenopathy and hoarseness, all point to a trigger that enters through the nasopharynx.…”

mentioning

confidence: 99%

Temporal Clusters of Kawasaki Disease Cases Share Distinct Phenotypes That Suggest Response to Diverse Triggers

Burns

DeHaan

Shimizu

et al. 2021

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective To test the hypothesis that cases of Kawasaki disease within a temporal cluster have a similar pattern of host response that is distinct from cases of Kawasaki disease in different observed clusters and randomly constructed clusters. Study design We designed a case-control study to analyze 47 clusters derived from 1332 patients with Kawasaki disease over a 17-yr. period (2002-2019) from a single clinical site and compared the cluster characteristics with two control groups of synthetic KD clusters. We defined a “true” KD cluster as at least 5 patients within a 7-day moving window. The observed and synthetic KD clusters were compared with respect to demographic and clinical characteristics and median values for standard laboratory data using univariate analysis and a multivariate, Rotated Empirical Orthogonal Function Analysis (REOFs). Results In a univariate analysis, the median values for age, coronary artery Z score, white blood cell count, erythrocyte sedimentation rate, C-reactive protein, and age-adjusted hemoglobin for several of the true KD clusters exceeded the 95th percentile for the two synthetic clusters. REOFs revealed distinct patterns of demographic and clinical measures within clusters. Conclusions Cases of Kawasaki disease within a cluster were more similar with respect to demographic and clinical features, and levels of inflammation than would be expected by chance. These observations suggest that different triggers and/or different intensity of exposures result in clusters of cases of Kawasaki disease that share a similar response pattern. Analyzing cases within clusters or cases who share demographic and clinical features may lead to new insights into the etiology of KD.

show abstract

The genetics of Kawasaki disease

Cited by 102 publications

References 38 publications

Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–2017

Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–2017

Kawasaki Disease

Temporal Clusters of Kawasaki Disease Cases Share Distinct Phenotypes That Suggest Response to Diverse Triggers

Contact Info

Product

Resources

About