The Genetics of IgA Deficiency

Crabbé, P. A.; Heremans, J. F.

doi:10.1016/b978-0-08-015566-1.50017-4

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Recently, simultaneous absence of IgG1, IgG2, IgG4, and IgAl subclasses was found, the deletion of a block of 'y -al -72 - 4 structural genes was postulated and confirmed by DNA analysis (26,27). As far as IgA deficiency is concerned, autosomal dominant and recessive modes of inheritance have been described (3)(4)(5). The finding of a normal percentage of lymphocytes carrying IgA in cases of selective IgA deficiency argues against a possible defect of structural a-genes (9).…”

Section: Resultsmentioning

confidence: 99%

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Selective deficiency of immunoglobulin A2.

Loghem¹,

Zegers²,

Bast³

et al. 1983

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

“…Several reports have been published on the familial occurrence of Ig deficiencies (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Selective deficiency of immunoglobulin A2.

Loghem¹,

Zegers²,

Bast³

et al. 1983

J. Clin. Invest.

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“…Since the initial description of isolated IgA deficiency in 2 healthy men [20], a great deal of attention has been focused on the genetics of this deficiency [7,19] and on the association of this type of immunological deficiency and disease [1]. In population studies, the frequency of selective IgA deficiency has been found to vary from 1/100 to 1/3,000 (table I).…”

Section: Introductionmentioning

confidence: 99%

Selective Serum IgA Deficiency

Frommel¹,

Moullec²,

Lambin³

et al. 1973

Vox Sanguinis

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The frequency of isolated IgA deficiency was determined in a healthy population of 15,200 volunteer French blood donors. The screening was performed either by inhibition of passive haemagglutination or by double diffusion analysis in gel. The results obtained with the two methods were concordant. In the Parisian population, the incidence of selective IgA deficiency characterized by a serum level below 0.5 IU, was found to be 1/3,040. This index is lower than that reported by most other investigators: 1/300- 1/3,000. These discrepancies depend on the type of population chosen for inquiry. In open and ethnically mixed populations, the incidence of IgA deficiency is lower than in more sedentary, rural, populations in which the probability of distant consanguinity is increased.

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Inherited Immunological Abnormality and the Gut

Lewkonia¹

1973

Clinics in Gastroenterology

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The Genetics of IgA Deficiency

Cited by 4 publications

References 16 publications

Selective deficiency of immunoglobulin A2.

Selective deficiency of immunoglobulin A2.

Selective Serum IgA Deficiency

Inherited Immunological Abnormality and the Gut

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