Neurotransmitters and Epilepsy 1987
DOI: 10.1007/978-1-59259-462-7_4
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The Genetically Epilepsy-Prone Rat

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Cited by 15 publications
(6 citation statements)
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References 30 publications
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“…The present study shows that sertraline decreas of the audiogenic seizures in a dose-depenc GEPR-9s. The data presented here also de systemic administration of sertraline, at the sa increased dose-dependently the extracellular 5 tions in the thalamus of freely moving GEPR ings confirm our earlier observation that drugs functional extracellular 5-HT decrease convulsion intensity in GEPRs (Laird & Jobe, 1987;Dailey et al, 1992b;Yan et al, 1994b). a Upon comparing the time courses of anticonvulsant effect with those of extracellular 5-HT concentration, we found that a negative correlation existed between extracellular 5-HT a concentration and audiogenic seizure intensity.…”
Section: Discussionsupporting
confidence: 89%
“…The present study shows that sertraline decreas of the audiogenic seizures in a dose-depenc GEPR-9s. The data presented here also de systemic administration of sertraline, at the sa increased dose-dependently the extracellular 5 tions in the thalamus of freely moving GEPR ings confirm our earlier observation that drugs functional extracellular 5-HT decrease convulsion intensity in GEPRs (Laird & Jobe, 1987;Dailey et al, 1992b;Yan et al, 1994b). a Upon comparing the time courses of anticonvulsant effect with those of extracellular 5-HT concentration, we found that a negative correlation existed between extracellular 5-HT a concentration and audiogenic seizure intensity.…”
Section: Discussionsupporting
confidence: 89%
“…The present study suggests, as have others (Laird and Jobe, 1987), that multiple seizure-related pathologies occur in these animals. Numerous neural deficits are present in the GEPR.…”
Section: J E Franck Et Almentioning
confidence: 48%
“…The genetically epilepsy prone rat (GEPR) has generalized clonic-tonic convulsions to loud tone and has been reported to have an increased seizure susceptibility to a variety of nonaudiogenic convulsant treatments, including pentylenetetrazol (PTZ), electroshock (Laird and Jobe, 1987), and kindling induction to angular bundle stimulation (Savage et al, 1986). Extensive work has been done on the nature of audiogenic seizures in the GEPR; pathology has been observed in both peripheral (Penny et al, 1983) and central auditory regions which apparently culminates in decreased functional inhibition in the central nucleus of the inferior colliculus (Faingold et al, 1986a,b).…”
mentioning
confidence: 99%
“…Chapman et al ( 1986), however, reported no significant differences in concentrations of GABA in striatum of seizure-susceptible and seizure-resistant rats, although in the present study, GABA concentrations were reduced by 41% in extracts of striaturn (caudate nucleus) of EP mice compared with ER controls ( p < 0.001). Based on pharmacological data, Laird and Jobe (1987) seizure-prone rats (Duplisse et al, 1974;Laird and Jobe, 1987), a defect in nigrostriatal GABAergic neurons might be expected to enhance the propagation of seizure activity. Lesions of the inferior colliculi abolish audiogenic seizures, whereas striatal lesions enhance seizure activity in rats (Kesner, 1966).…”
Section: Amino Acid Concentrations In E P Micementioning
confidence: 99%