The genetic variant of lactase persistence C (−13910) T as a risk factor for type I and II diabetes in the Finnish population

Abstract

Objective: Lactase persistence (LP), the ability to maintain a high lactase activity throughout life, has been suggested to be a possible risk factor for diabetes. Recently, a single nucleotide polymorphism C (À13910) T, residing 14 kb from the 5 0 end of the lactase (LCT) gene was shown to be associated with LP. Here we have studied the relationship between C (13910) T polymorphism and diabetes in the Finnish population. Patients and design: In all, 1455 patients with type I and 615 with type II diabetes and 446 nondiabetic controls in the Finnish population were genotyped for the C (-13910) T polymorphism by PCR minisequencing. Results: No differences were detected in the LP genotype frequencies (CT&TT) between diabetic and nondiabetic subjects. Conclusions: We conclude that the C (À13910) T polymorphism associated with lifelong LP is not a risk factor for type I or type II diabetes in the Finnish population.

The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

“…The frequency of 10.1% is in agreement with the frequency of 8.7% in an earlier study of the prevalence of the C/C 213910 genotype and LM in the Swedish speaking population of Finland. 20 The prevalence of LM among patients born in Karelia (n = 111) was 26.1%, which is in line with our original study showing an average LM prevalence of 23% in Eastern Finland. 14 The frequency of LM is strongly dependent on ethnic origin.…”

“…Control subjects were participants in a Finnish multicentre study, FinnDiane, aiming to elucidate the genetic background of diabetic nephropathy, and they had been genotyped for the C/T 213910 variant associated with lactose malabsorption (LM). 20 To increase the number of healthy controls, we genotyped an additional 34 Finnish blood donors from the corresponding geographical areas. All samples were handled anonymously.…”

The genetic variant of lactase persistence C/T (13910) and blood glucose control in type 1 diabetes mellitus patients

“…Furthermore, intestinal barrier integrity is nowadays considered a basic element of good health [12]. Indeed there is clear evidence that a "chronic phlogosis" condition, such as that caused by gluten in coeliac disease, can favour the onset of many diseases, in particular autoimmune ones.…”

“…As a consequence, this situation can contribute to the onset of obesity and of increase the risk of diabetes [11]. On the contrary, a genetic study on a Finnish population searching for C variant (13910)T of LP showed that there is no association between LP and risk of diabetes 1 and 2 [12].…”

Nutrigenómica: Revelando Los Aspectos Moleculares De Una Nutrición Personalizada

“…Enattah et al (112) observaron polimorfismo para el gen de la lactasa C (-13910) en la población finlandesa. Al producirse un cambio en el gen de la lactasa ubicado en el cromosoma 22, que consiste en un cambio C a T en la ubicación 13910 río arriba, se observa que el genotipo CC tiene una baja actividad de lactasa, mientras que los genotipos CT y el TT se relacionan con persistencia de la síntesis de lactasa.…”