The genetic toxicology of acridines

Ferguson, Lynnette R.; Denny, William A.

doi:10.1016/0165-1110(91)90006-h

Cited by 133 publications

(102 citation statements)

References 132 publications

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“…Inhibition rates of mutagenesis in TA1537 ranged from 49.14% to 65.41% for compound 1 and from 30.06 to 75.94% for compound 2 (Table 3). 9-AA, a member of acridine family, is known as a model frame-shift mutagen (Ferguson & Denny, 1991). In the frame-shift mutagenesis mechanism, it binds to DNA non- a NaN 3 (1 mg/plate) and 9-AA (40 mg/plate) were used as positive controls for S. typhimurium TA1535 and TA1537 strains, respectively.…”

Section: Genotoxic and Antigenotoxic Activity Evaluationmentioning

confidence: 99%

Two antigenotoxic chalcone glycosides fromMentha longifoliasubsp.longifolia

Güvenalp

Özbek

Karadayı

et al. 2014

Pharmaceutical Biology

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Context: Mentha L. (Labiatae) species (mint) with their flavoring properties have been used in food industries for centuries. Besides they have a great importance in drug development and medicinal applications due to various bioactive compounds of several members of the genus. Objective: The aim of this study was to isolate bioactive compounds with antimutagenic potential by bio-guided fractionation and determine their structures by spectroscopic methods. Materials and methods: The structural elucidation of the isolated compounds was done based on spectroscopic methods, including MALDI-MS, UV, IR, and 2D NMR experiments, and the bioguided fractionation process was done by using the Ames/Salmonella test system. Henceforth, solely genotoxic and antigenotoxic potential of the new compounds were also confirmed up to 2 mM/plate by using the same test system. According to the antimutagenicity results, both new test compounds significantly inhibited the mutagenic activity of 9-aminoacridine in a dose-dependent manner at the tested concentrations from 0.8 to 2 mM/plate. (bR)-b,4,2 0 ,6 0 -Tetrahydroxy-4 0 -O-rutinosyldihydrochalcone showed the maximum inhibition rate as 75.94% at 2 mM/plate concentration. Conclusions: This is the first report that two new chalcone glycosides were isolated from Mentha longifolia subsp. longifolia and their antimutagenic potentials by using mutant bacterial tester strains. In conclusion, the two new chalcone glycosides showed a significant antigenotoxic effect on 9-aminoacridine-induced mutagenesis at tested concentrations.

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Section: Genotoxic and Antigenotoxic Activity Evaluationmentioning

confidence: 99%

Two antigenotoxic chalcone glycosides fromMentha longifoliasubsp.longifolia

Güvenalp

Özbek

Karadayı

et al. 2014

Pharmaceutical Biology

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“…However, we were unable to find in the literature the spectral data and interaction constants of QM binding to DNA. Furthermore, it is difficult to assess whether QM binding is reversible because this intercalator is also known to bind covalently to DNA [30]. QM was used in studies of CHL and caffeine as the "interceptors" neutralizing biological activity of aromatic mutagens; CHL protected HL-60 and MCF-7 cells from QM but not from nitrogen mustard, the latter having similar chemical reactive moiety as QM but lacking the aromatic structure [31,32].…”

Section: Intercalator-dna Systemmentioning

confidence: 99%

The “interceptor” properties of chlorophyllin measured within the three-component system: Intercalator–DNA–chlorophyllin

Pietrzak

Wieczorek

et al. 2006

Biophysical Chemistry

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In aqueous solutions, in the presence of double-stranded DNA, chlorophyllin (CHL) forms complexes with each of the three DNA intercalators: acridine orange (AO), quinacrine mustard (QM), and doxorubicin (DOX). The evidence for these interactions was obtained by measurement changes in the absorption and fluorescence spectra of the mixtures containing DNA and intercalators during titration with CHL. A model of simple competition between DNA and CHL for the intercalator was used to define the measured interactions. The concentrations of the complexes estimated based on this model were consistent with the concentrations obtained by actual measurement of the absorption spectra.The present data provide further support for the role of chlorophyllin as an "interceptor" that may neutralize biological activity of aromatic compounds including mutagens and antitumor drugs.

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“…1,2,3 Indeed acridines exhibit great pharmaceutical importance due to their potent photodynamic biological activities. 4 However this goes hand-in-hand with its well established toxicity profile 5 of the molecule itself which represents a considerable obstacle to overcome for progression into main stream healthcare. In contrast, 7,8-dimethyl-10-ribityl isoalloxazine (riboflavin or vitamin B2) is an essential nutrient in humans, and is also a photosensitiser which absorbs in the visible region.…”

Section: Graphical Abstract Submitted To Tetrahedron Lettersmentioning

confidence: 99%