The genetic structure of Escherichia coli populations in feral house mice

Gordon, David M.

doi:10.1099/00221287-143-6-2039

Cited by 54 publications

(60 citation statements)

References 29 publications

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“…Whittam et al (1983) reported that about 2 % of the allelic diversity in E. coli isolated from humans living on three continents was explained by a geographical effect. In a study of E. coli isolated from two populations of feral house mice, Genetic structure of enteric bacteria 15 km apart, locality was found to explain about 5 % of the genetic variation (Gordon, 1997). These values are comparable to those observed in this study for E. coli (4-6 %).…”

Section: Population Structuresupporting

confidence: 76%

“…Although studies of electrophoretic variation at multiple enzyme loci (MLEE) has provided much support for the clonal paradigm, especially for Escherichia coli (Milkman, 1973 ;Selander & Levin, 1980 ;Caugant et al, 1981Caugant et al, , 1984Whittam et al, 1983 ;Pupo & Richardson, 1995 ;Gordon, 1997), the results of these studies have also highlighted some of the problems with the concept. Maynard Smith (1991) maintains that two observations are common in the majority of MLEE studies : (1) bacterial populations exhibit extensive genetic diversity ; and (2) populations are ' clonal ', that is, the same haplotype is recovered repeatedly.…”

Section: Introductionmentioning

confidence: 87%

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The genetic structure of enteric bacteria from Australian mammals

Gordon

Lee

1999

Microbiology

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A total of 246 isolates representing five species of the family Enterobacteriaceae, taken from a variety of Australian mammal species, were characterized using multi-locus enzyme electrophoresis. Genome diversity estimates varied significantly among species, with the Klebsiella pneumoniae sample exhibiting the lowest diversity and the Citrobacter freundii sample the highest. Multi-locus linkage disequilibrium estimates revealed that alleles were non-randomly associated in all five species samples, but the magnitude of the estimates differed significantly among species. Escherichia coli had the lowest linkage disequilibrium estimate and Klebisella oxytoca the largest. Molecular analyis of variance was used to determine the extent to which population structure explained the observed genetic variation in a species. Two population levels were defined : the taxonomic family of the host from which the isolate was collected and the geographical locality where the host was collected. The amount of explained variation varied from 0 % for K. oxytoca to 22 % for K. pneumoniae. Host locality explained a significant amount of the genetic variation in the C. freundii (12 %), E. coli (5 %), Hafnia alvei (17 %) and K. pneumoniae (22 %) samples. Host family explained a significant fraction of the variation in E. coli (6 %) H. alvei (7 %) and K. pneumoniae (20 %). Estimates of effective population size for all five species, based on the probability that two randomly chosen isolates will be identical, failed to reveal any relationship between the effective population size and the genetic diversity of a species.

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Section: Population Structuresupporting

confidence: 76%

Section: Introductionmentioning

confidence: 87%

The genetic structure of enteric bacteria from Australian mammals

Gordon

Lee

1999

Microbiology

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“…1983a ; Pupo & Richardson, 1995 ;Gordon, 1997). These investigations have provided strong support for the idea that E. coli is essentially clonal (Selander et al, 1987).…”

Section: Introductionmentioning

confidence: 56%

The distribution of enteric bacteria from Australian mammals: host and geographical effects

Gordon

FitzGibbon

1999

Microbiology

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Bacteria of the family Enterobacteriaceae were isolated from 642 mammalian hosts, representing 16 families and 79 species, collected from throughout Australia. Escherichia coli was the most common of the 24 enteric species recovered and represented almost half of the isolates. Association analysis revealed that most other species of bacteria were less likely to be recovered from hosts in which E. coli was present. The composition of the enteric community of a host was found to be determined by both the taxonomic family to which the host belonged and the geographical area from which the host was collected. Hosts collected from the northern areas of Queensland and the Northern Territory had more diverse enteric communities than hosts collected from New South Wales or Western Australia. Hosts of the families Petauridae and Vespertilionidae had more diverse enteric communities than did members of the Macropodidae or Phalangeridae. The probability of occurrence of Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Hafnia alvei, Klebsiella oxytoca and K. pneumoniae in a host was found to vary with respect to host family and/or host locality. The non-random distribution of these species demonstrates the presence of extensive population structure and may suggest the existence of adaptations specific to both the primary and secondary habitats of these enteric bacteria.

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“…In excess of 500 mice were collected on 6 occasions during the summer and autumn of 1993/94 by establishing trapping transects in a single field on each property. Further details of the age and sex structure of the mouse population are presented by Gordon (1997).…”

Section: Methodsmentioning

confidence: 99%

“…The Lac+ Cit-isolates were presumed to be E. coli and the identifications were subsequently confirmed using additional biochemical criteria. Further details of the clone isolation and identification procedures are given by Gordon (1997).…”

Section: Isolation and Characterization Of Bacteriamentioning

confidence: 99%

Temporal changes in the frequency of colicinogeny in Escherichia coli from house mice

1998

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Escherichia coli was isolated from feral house mice (Mus domesticus) during the course of a mouse plague in the state of Victoria, Australia. The isolates were characterized for the production of colicins and their resistance to the cooccurring colicins. Of the 447 isolates examined, 59% were found to be col icinogenic. Phenotypic and PCR-based genotypic methods were used to determine the types of colicins being produced. Colicin E2 was the most common, representing 27 O / o of the colicin-producing isolates. Colicin la was produced by 3 O/ O of the colicinogenic isolates. The remaining colicins could not be identified, but phenotypic and PCR data argue that at least nine different colicin types are present in this collection of E. coli. The frequency of colicinogenic isolates declined from 71 O/ O to 43% over the 7 months of the study. All colicin types appeared to decline in frequency. Concurrently, the resistance of isolates to colicin E2 increased from about 50% to 70%. Two hypotheses are proposed to explain the decline in the frequency of colicinogeny in this population of E. coii. The first relates to the within-host interactions occurring among colicinogenic, colicin-susceptible and colicinresistant populations within a host. The second relates to the among-host interactions between susceptible and colicinogenic populations and the effect of host population densities on these interactions.

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The genetic structure of Escherichia coli populations in feral house mice

Cited by 54 publications

References 29 publications

The genetic structure of enteric bacteria from Australian mammals

The genetic structure of enteric bacteria from Australian mammals

The distribution of enteric bacteria from Australian mammals: host and geographical effects

Temporal changes in the frequency of colicinogeny in Escherichia coli from house mice

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