The genetic landscape of Mediterranean North African populations through complete mtDNA sequences

Font-Porterias, Neus; Solé-Morata, Neus; Serra-Vidal, Gerard; Bekada, Asmahan; Fadhlaoui-Zid, Κarima; Zalloua, Pierre; Calafell, Francesc; Comas, David

doi:10.1080/03014460.2017.1413133

Cited by 16 publications

(11 citation statements)

References 49 publications

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“…miR-21, miR-183, miR-182, miR-425-5p and miR-200c were found to be upregulated in tumor versus normal adjacent breast tissues, similar to the Lebanese patients and patients in other studies reported in the literature [20,25]. This study is the first to report the patterns of miRNA dysregulation in the Algerian population, one of North African populations that are known to possess great gene pool heterogeneity from Eurasia, Sub Saharan Africa and North Africa [49]. Furthermore, several meta-analyses report ethnic differences in miRNA deregulations in cancer [50,51].…”

Section: Discussionsupporting

confidence: 83%

miRNA expression in advanced Algerian breast cancer tissues

et al. 2020

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Breast cancer is one of the commonest cancers among Algerian females. Compared to Western populations, the median age of diagnosis of breast cancer is much lower in Algeria. The objective of this study is to explore the expression of several miRNAs reported to be deregulated in breast cancer. The miRNAs miR-21, miR-125b, miR-100, miR-425-5p, miR-200c, miR-183 and miR-182 were studied on tumor and normal adjacent Algerian breast tissues using quantitative reverse transcription real time PCR, and the results were analyzed according to clinical characteristics. Compared to the normal adjacent tissues, miR-21, miR-183, miR-182, miR-425-5p and miR-200c were found to be upregulated while miR-100 and miR-125b were insignificantly deregulated. A positive correlation was noted among miR-183, miR-182 and miR-200c and among miR-425-5p, miR-183, miR-200c and miR-21. Further global miRNA microarray profiling studies can aid in finding ethnic specific miRNA biomarkers in the Algerian breast cancer population.

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Section: Discussionsupporting

confidence: 83%

miRNA expression in advanced Algerian breast cancer tissues

et al. 2020

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“…In addition, mitogenomes and their Hg were successfully determined from 18 modern Ibizans (Table 1 ). A Median Joining network of 111 mitogenomes representing the ancient and modern mitogenomes generated in this study with 83 publicly available ancient mitogenomes from European and Near Eastern 3 , 23 , 29 , 34 – 36 and modern North African 37 populations is shown in Fig. 1 .…”

Section: Resultsmentioning

confidence: 99%

Ancient DNA of Phoenician remains indicates discontinuity in the settlement history of Ibiza

Zalloua

Collins

Gosling

et al. 2018

Sci Rep

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Ibiza was permanently settled around the 7th century BCE by founders arriving from west Phoenicia. The founding population grew significantly and reached its height during the 4th century BCE. We obtained nine complete mitochondrial genomes from skeletal remains from two Punic necropoli in Ibiza and a Bronze Age site from Formentara. We also obtained low coverage (0.47X average depth) of the genome of one individual, directly dated to 361–178 cal BCE, from the Cas Molí site on Ibiza. We analysed and compared ancient DNA results with 18 new mitochondrial genomes from modern Ibizans to determine the ancestry of the founders of Ibiza. The mitochondrial results indicate a predominantly recent European maternal ancestry for the current Ibizan population while the whole genome data suggest a significant Eastern Mediterranean component. Our mitochondrial results suggest a genetic discontinuity between the early Phoenician settlers and the island’s modern inhabitants. Our data, while limited, suggest that the Eastern or North African influence in the Punic population of Ibiza was primarily male dominated.

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“…To evaluate the geographical pattern of variation in the shape of the birth canal, we compared the variation in pelvic indices among continents using ANOVA and a post hoc Tukey test. North African (here represented by Egypt) and European populations were analysed together, as movement of people across and around the Mediterranean appears to have been higher than across the Sahara Desert [48,49].…”

Section: (A) Variation In Shape and Sizementioning

confidence: 99%

Human variation in the shape of the birth canal is significant and geographically structured

Betti

Manica

2018

Proc. R. Soc. B.

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The human birth canal shows a tight fit with the size of the neonate, which can lead to obstetric complications. This is not the case in other apes, and has been explained as the outcome of conflicting evolutionary pressures for bipedal locomotion and parturition of a highly encephalized fetus. Despite the suggested evolutionary constraints on the female pelvis, we show that women are, in fact, extremely variable in the shape of the bony birth canal, with human populations having differently shaped pelvic canals. Neutral evolution through genetic drift and differential migration are largely responsible for the observed pattern of morphological diversity, which correlates well with neutral genetic diversity. Climatic adaptation might have played a role, albeit a minor one, with populations from colder regions showing a more transversally oval shape of the canal inlet. The significant extent of canal shape variation among women from different regions of the world has important implications for modern obstetric practice in multi-ethnic societies, as modern medical understanding has been largely developed on studies of European women.

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The genetic landscape of Mediterranean North African populations through complete mtDNA sequences

Abstract: The analysis of the complete mtDNA genome has allowed for the identification of a North African sub-lineage that might be ignored by the analysis of partial mtDNA control region sequences, highlighting the phylogeographic relevance of mtDNA complete sequence analysis.

Cited by 16 publications

References 49 publications

miRNA expression in advanced Algerian breast cancer tissues

miRNA expression in advanced Algerian breast cancer tissues

Ancient DNA of Phoenician remains indicates discontinuity in the settlement history of Ibiza

Human variation in the shape of the birth canal is significant and geographically structured

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