The Genetic-Epigenetic Pathophysiology of Endometriosis: A Surgeon’s View

Koninckx, Philippe; Ussia, Anastasia; Adamyan, L.V.; Keckstein, J; Wattiez, Arnaud; Gomel, Victor; Martin, D.C.

doi:10.1007/978-3-030-52984-0_6

Cited by 22 publications

(29 citation statements)

References 149 publications

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“…These incidents are a result of specific pathological influence: both genetic and not genetic. A major influencing factor is inflammation, 98 resulting from both bacterial and viral presence. Recently, it has been discussed that the genetic-epigenetic factors supporting endometriotic cellular transformation are potentiated by environmental pollution, oxidative stress and inflammation-inducing agents.…”

Section: Resultsmentioning

confidence: 99%

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Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature

Михалева¹,

Radzinsky²,

Оразов³

et al. 2021

IJWH

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Objective To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. Methods A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. A multilingual search was performed. Results Several mechanisms underline the pathophysiological pathways for endometriosis development. Epigenetic mutations, external and internal influences, and chronic conditions have a significant impact on endometriosis development, survival and regulation. Several historically valid theories on endometriosis development were discussed, as well as updated findings. Conclusion Despite recent advances, fundamental problems in understanding endometriosis remain unresolved. The identification of unknown circulating epithelial progenitors or stem cells that are responsible for epithelial growth in both the endometrium and endometriotic foci seems to be the next step in solving these questions.

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Section: Resultsmentioning

confidence: 99%

“…Recently, it has been discussed that the genetic-epigenetic factors supporting endometriotic cellular transformation are potentiated by environmental pollution, oxidative stress and inflammation-inducing agents. 99 …”

Section: Resultsmentioning

confidence: 99%

Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature

Михалева¹,

Radzinsky²,

Оразов³

et al. 2021

IJWH

View full text Add to dashboard Cite

show abstract

“…To explain the absence of progression in most women and with observations, such as the clonal aspect of endometriotic lesions, the genetic-epigenetic (G-E) theory (4) postulates that the onset of the disease/invasion requires that the cumulative set of G-E incidents has reached a certain threshold. The polygenetic inheritance determines the susceptibility of developing the disease when additional G-E incidents occur because of mutagenic substances, the oxidative stress of (retrograde) menstruation and infection/microbiota in the peritoneum or upper genital tract (5). Although inflammation fits in the model of endometrial stromal cell invasion, this study cannot differentiate whether the initial invading cells causing endometriosis are G-E normal or abnormal.…”

Section: Do We Need To Separate Initiation and Growth To Understand Endometriosis?mentioning

confidence: 90%

Do we need to separate initiation and growth to understand endometriosis?

Koninckx

Martin

Donnez³

2020

Fertility and Sterility

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“…These areas may become infected, resulting in abscess formation. She also had recurrent pelvic abscess, which suggested endometriosis as the cause of the pelvic abscess [ 5 , 6 ]. While the patient was being medically treated for endometriosis, she had repeated pelvic abscesses.…”

Section: Case Presentationmentioning

confidence: 99%

Bowel obstruction due to Chlamydia trachomatis: a case report and review of literature

et al. 2021

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Background Chlamydial infection is a difficult-to-diagnose type of sexually transmitted disease that occurs mainly in young people. We report a case of bowel obstruction caused by intrapelvic adhesions formed by chlamydial infection. Case presentation This patient was a 23-year-old woman who had been suffering from acute abdominal pain. She had been previously treated several times for intrapelvic abscesses and had a history of chlamydial infection. Endometriosis was thought to be the cause of her pelvic abscess based on endoscopic findings. Computed tomography demonstrated a small bowel obstruction caused by a pelvic abscess. However, the diagnosis could not be confirmed. She underwent laparoscopic surgery and was diagnosed with bowel obstruction due to adhesion of chlamydial infection based on the intraoperative findings and Chlamydia trachomatis antibody test. She was discharged 5 days after surgery. Conclusions It is necessary to consider the possibility of chlamydial infection as a cause for lower abdominal pain and unexplained bowel obstruction in female patients.

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The Genetic-Epigenetic Pathophysiology of Endometriosis: A Surgeon’s View

Cited by 22 publications

References 149 publications

Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature

Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature

Do we need to separate initiation and growth to understand endometriosis?

Bowel obstruction due to Chlamydia trachomatis: a case report and review of literature

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