The genetic epidemiology of idiopathic scoliosis

Gorman, Kristen F.; Julien, Cédric; Moreau, Alain

doi:10.1007/s00586-012-2389-6

Cited by 101 publications

(79 citation statements)

References 102 publications

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“…This spinal deformation occurs mostly among pubescent girls [4]. Many authors emphasize multifactorial pathomechanism of scoliosis [5][6][7][8], and the involvement of genetic and epigenetic predispositions, and the influence of hormonal factors are widely accepted [6,7,[9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Kulis

Goździalska

Drąg

et al. 2015

International Orthopaedics (SICOT)

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Purpose In order to verify the potential association between the aetiopathogenesis of adolescent idiopathic scoliosis (AIS) and the process of sexual maturation, we determined the concentrations of oestrogens in pre-and postmenarcheal girls affected by this condition. AIS, occurring mostly in pubescent girls, is one of the most frequent forms of faulty posture. Therefore, it was assumed that the multifactorial pathomechanism of AIS involves significant deficiency of oestrogens. Methods The diagnosis of AIS was established on the basis of physical examination and analyses of radiograms. Concentrations of FSH, LH, oestrogens, progesterone, osteocalcin and RANKL were determined by ELISA. The activity of alkaline phosphatase (AP) was measured by kinetic method. The study included pre-and postmenarcheal girls with AIS and corresponding groups of scoliosis-free controls. Results In premenarcheal scoliotic girls, the levels of FSH, LH and oestradiol were lower; the levels of progesterone, oestrone and oestriol were higher; and the concentrations of oestrone and oestriol were similar compared to premenarcheal controls. Higher levels of RANKL, osteocalcin and AP were observed in premenarcheal adolescents with AIS compared to controls. The concentrations of FSH, LH, oestradiol, and progesterone in postmenarcheal girls with scoliosis were lower, oestrone were slightly lower and oestriol did not differ compared with the control group. Significantly higher levels of RANKL, osteoc alcin an d A P w ere o bserv ed i n postmenarcheal scoliotic adolescents compared with controls. Conclusions There is an interdependence between the concentration of oestradiol and development of scoliosis. Determination of estradiol may have diagnostic value in the screening of spinal pathologies associated with AIS.

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Section: Introductionmentioning

confidence: 99%

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Kulis

Goździalska

Drąg

et al. 2015

International Orthopaedics (SICOT)

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“…The AIS may resolve spontaneously, with growth, or may progress severely and even be associated with risk of mortality (1,15). The progressive deformity may cause several body prominences, asymmetric waistline, uneven shoulders, injured self-image, pain, spinal degenerative changes, limitations in activities of daily living and, in severe cases, disturbed pulmonary function (29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

“…Idiopathic scoliosis is a complicated three dimensional deformity and the most common spinal deformity (1). Adolescent idiopathic scoliosis (AIS) is the most common form of idiopathic scoliosis (over 80%) with an onset at puberty and female predominance (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Idiopathic Scoliosis: Males Versus Females

Mahabadi¹,

Ghandehari²,

Mahdavi³

et al. 2015

Shafa Ortho J

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Background: Treatment of adolescent idiopathic scoliosis (AIS) is one of the most challenging problems for spine surgeons. Although it has been previously demonstrated that curve pattern in AIS is different between males and females, there are, however, limited studies specially focused on the differences of AIS characteristics between the two genders. Objectives: In current study, we compared the demographics and curve patterns in male and female patients with AIS. Patients and Methods: A total of 68 girls and 17 boys with AIS were included in this cross-sectional study. The magnitude of curvature, thoracic kyphosis, flexibility and pattern of the deformity were measured on x-rays and compared between the two genders. Results: Although girls were significantly younger (15.3 ± 2.5 versus 16.7 ± 2.1 years; P = 0.036), however, the Risser sign was the same. Most of the males were hypokyphotic (70.6%), while most of the girls had normal thoracic kyphosis (69.1%) (P = 0.001). The main scoliotic curve (77.2 ± 18.2 versus 59.6 ± 18.6 degrees) and flexibility (25.5% ± 18.2% versus 41.9% ± 18.6%) were significantly greater and lower in males, respectively (P < 0.05). The typical AIS pattern was present in 64.7% of boys and 95.6% of girls (P < 0.001). Conclusions:The radiographic characteristics of AIS are substantially different between genders. In male patients, AIS is more severe and rigid compared to females. Also, hypokyphosis and atypical pattern of AIS are common findings in males compared to females.

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“…Se trata de un síndrome complejo del desarrollo (Gorman et al, 2012) que aparece en la infancia y produce una inclinación lateral en el plano frontal junto a una rotación vertebral. A pesar de no tener una causa claramente definida, parece tener una causa multifactorial (Pérez-Caballero Macarrón et al, 2006) donde pueden estar implicados el sexo y la edad, así como factores de tipo genético (Grauers et al, 2012).…”

Section: Introductionunclassified

Relación Entre Escoliosis, Sexo y Lateralidad Manual en una Muestra de Escolares

Fernández

Zurita

et al. 2015

Int. J. Morphol.

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RESUMEN:De todo el conjunto de problemas que se desarrollan en la infancia, no cabe duda que la escoliosis ocupa un puesto importante debido a sus repercusiones en la edad temprana y adulta. El objetivo del estudio fue evaluar la relación existente entre el sexo, escoliosis y lateralidad manual. La muestra estuvo formada por 2822 participantes, con edad comprendida entre 6 y 12 años, pertenecientes a la provincia de Almería. Se utilizaron dos instrumentos de medida, es decir, inventario de lateralidad manual de Edinburgh y la prueba de Adams, para analizar las variables seleccionadas. No se encontraron diferencias estadísticamente significativas entre las variables lateralidad y sexo (p=0,106) ni entre lateralidad y escoliosis (p=0,673); pero sí entre escoliosis y sexo (p<0,001). Como principales conclusiones debemos señalar la importancia en el desarrollo de adecuados programas de intervención teniendo en cuenta el número obtenido de niños con escoliosis, sobre todo en niñas.

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The genetic epidemiology of idiopathic scoliosis

Cited by 101 publications

References 102 publications

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Adolescent Idiopathic Scoliosis: Males Versus Females

Relación Entre Escoliosis, Sexo y Lateralidad Manual en una Muestra de Escolares

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