The Genetic Control of Meiosis

Baker, Bruce S.; Carpenter, Adelaide T. C.; Esposito, Michael S.; Esposito, Rochelle Easton; Sandler, L.

doi:10.1146/annurev.ge.10.120176.000413

Cited by 573 publications

(233 citation statements)

References 152 publications

Supporting

Mentioning

224

Contrasting

Unclassified

Order By: Relevance

“…This lower fertility is unlikely to be a consequence of aberrant gametogenesis, because genetic transmission of markers was not significantly altered in crosses in different directions. Environmental factors were shown to inf luence rates of meiotic recombination, which often affect particular genomic regions (6). For both mutants examined we have determined levels of meiotic recombination at two unlinked genomic locations.…”

Section: Discussionmentioning

confidence: 99%

“…In mammalian cells and yeast, high recombination frequency is confined to transcriptionally active regions, and this also has been concluded for maize (4). As in other organisms (5), the frequency of meiotic recombination in plants is influenced by environmental factors (6), sequence diversity in interspecific crosses (7), and the direction of crossing (8). In somatic cells, rates of homologous recombination can be stimulated by DNA-damaging treatments (9)(10)(11).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Arabidopsis thaliana mutants altered in homologous recombination

Masson¹,

Paszkowski²

1997

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Homologous recombination contributes both to the generation of allelic diversity and to the preservation of genetic information. In plants, a lack of suitable experimental material has prevented studies of the regulatory and enzymatic aspects of recombination in somatic and meiotic cells. We have isolated nine Arabidopsis thaliana mutants hypersensitive to x-ray irradiation (xrs) and examined their recombination properties. For the three xrs loci described here, single recessive mutations were found to confer simultaneous hypersensitivities to the DNA-damaging chemicals mitomycin C (MMC s ) and͞or methyl methanesulfonate (MMS s ) and alterations in homologous recombination. Mutant xrs9 (Xray s , MMS s ) is reduced in both somatic and meiotic recombination and resembles yeast mutants of the rad52 epistatic group. xrs11 (Xray s , MMC s ) is deficient in the x-ray-mediated stimulation of homologous recombination in somatic cells in a manner suggesting a specific signaling defect. xrs4 (Xray s , MMS s , MMC s ) has a significant deficiency in somatic recombination, but this is accompanied by meiotic hyper-recombination. A corresponding phenotype has not been reported in other systems and thus this indicates a novel, plant-specific regulatory circuit linking mitotic and meiotic recombination.Many similarities in DNA repair and recombination have been noted between plants, yeast, and higher eukaryotes. Meiotic recombination events in Arabidopsis thaliana (1) and maize (2) are unequally distributed along chromosomes, resulting in silent or hot spots of recombination, as in mammalian cells or yeast (3). In mammalian cells and yeast, high recombination frequency is confined to transcriptionally active regions, and this also has been concluded for maize (4). As in other organisms (5), the frequency of meiotic recombination in plants is influenced by environmental factors (6), sequence diversity in interspecific crosses (7), and the direction of crossing (8). In somatic cells, rates of homologous recombination can be stimulated by DNA-damaging treatments (9-11). This also has been observed in bacteria, yeast, and mammalian cells (12). However, a closer comparison reveals that plant cells are highly resistant to DNA-damaging treatments and are significantly more prone to the induction of increased recombination levels (9-11) than animal cells (13). This feature may be relevant for the late differentiation of germ cells in plants and the potential transmission of somatic recombination events to the germ-line (14, 15). Interestingly, genomic changes are influenced by environmental stresses (16,17), and specific induction of intrachromosomal homologous recombination by heat and salt stress has been documented (10, 11). Thus, regulation of genome stability during plant development is especially important. To help decipher enzymatic and regulatory aspects of DNA metabolism in plants, we isolated A. thaliana mutants hypersensitive to x-ray irradiation (xrs for x-ray sensitive), which also showed elevated sensitivity to DN...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Arabidopsis thaliana mutants altered in homologous recombination

Masson¹,

Paszkowski²

1997

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The genetic control of meiosis in diploid species has been studied by the use of meiotic mutants (Baker et al, 1976), but an analysis similar to that in hexaploid wheat has not been possible since nullisomics or monosomics are lethal. However, monosomy or nullisomy can be tolerated by diploid species when compensating homoeologous chromosomes are present.…”

Section: Introductionmentioning

confidence: 99%

Genetic control of meiotic pairing in rye

Naranjo

Palla

1982

Heredity

View full text Add to dashboard Cite

SUMMARYMeiotic pairing in euploid rye-triticale hybrids (ABRR, 2n = 28) is compared with that in three hypoaneuploid ABRR hybrids, two with 2n = 26 chromosomes and one with 2n =27, also obtained from the cross triticale by rye. The results show that the application of hypoaneuploidy compensated by homoeologous chromosomes is useful in the study of genetic control of meiotic pairing in diploid species. The aneuploid with 2n = 27 chromosomes was identified as mono-5R by C-banding; its meiotic pairing indicated that chromosome 5R of rye is a strong promoter of homologous rye pairing and is also able to influence non-homologous (probably homoeologous) wheat chromosome pairing. This result reinforces Feldman's (1968) view that the Ph locus of hexaploid wheat arose by mutation of a promoter gene.

show abstract

“…Examples of achiasmate organisms in which the chromosomes nevertheless remain paired until anaphase I onset are well known (see Baker et al, 1976). The C-heterochromatin bands in the chromosome arms analyzed are almost certainly telomeric.…”

Section: Discussiormentioning

confidence: 99%

Metaphase I bound arms and crossing over frequency in rye III. Non-chiasmate bonds in desynaptic plants

Orellana

Giráldez

1983

Heredity

View full text Add to dashboard Cite

SUMMARYIn order to analyze the correspondence between the number of metaphase I bonds and the chiasma frequency of specific chromosome arms in desynaptic plants, two Fl hybrids were backcrossed to the parental inbred lines. The plants obtained were desynaptic. Some of these plants were heterozygous for a prominent telomeric C-band in chromosomes 1R (long arm) and/or 2R (short arm).From the frequency of bound arms at metaphase I and the frequency of recombined chromosomes at anaphase I in the arms considered, estimates of chiasma frequencies have been derived. The results have been compared with those obtained for the Fls between inbred lines from which the desynaptic plants were produced Orellana and Giraldez, 1981) as well as with those obtained in an open pollinated variety of rye (Orellana and Giraldez, 1981). The excess of anaphase I parental chromosomes found in the desynaptic plants can be explained on the assumption that some of the bonds appearing at metaphase I are achiasmate and a remnant of prophase pairing.

show abstract

The Genetic Control of Meiosis

Cited by 573 publications

References 152 publications

Arabidopsis thaliana mutants altered in homologous recombination

Arabidopsis thaliana mutants altered in homologous recombination

Genetic control of meiotic pairing in rye

Metaphase I bound arms and crossing over frequency in rye III. Non-chiasmate bonds in desynaptic plants

Contact Info

Product

Resources

About