2013
DOI: 10.1111/jmp.12043
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The genetic composition of populations of cynomolgus macaques (Macaca fascicularis) used in biomedical research

Abstract: Background The genetic composition of cynomolgus macaques used in biomedical research is not as well-characterized as that of rhesus macaques. Methods Populations of cynomolgus macaques from Sumatra, Corregidor, Mauritius, Singapore, Cambodia and Zamboanga were analyzed using 24 STRs. Results The Sumatran and Cambodian populations exhibited the highest allelic diversity while the Mauritian population exhibited the lowest. Sumatran cynomolgus macaques were the most genetically similar to all others, consist… Show more

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Cited by 69 publications
(91 citation statements)
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References 61 publications
(117 reference statements)
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“…Animals used in research are sourced from many of these locations and, while subpopulation differences are still minimally studied, potentially important genetic differences between populations are already recognized [21, 22]. Mauritian macaques are attractive for biomedical research for a number of reasons.…”
Section: Introductionmentioning
confidence: 99%
“…Animals used in research are sourced from many of these locations and, while subpopulation differences are still minimally studied, potentially important genetic differences between populations are already recognized [21, 22]. Mauritian macaques are attractive for biomedical research for a number of reasons.…”
Section: Introductionmentioning
confidence: 99%
“…Mauritian cynomolgus macaques (MCM) represent a newer potential model system. MCM originate from the island of Mauritius, and they have limited major histocompatibility complex diversity due to extreme founder effects that created a tight genetic bottleneck (36). Aerosol challenge with M. tuberculosis has been described in these animals (21,37), and they appeared to be quite susceptible to TB.…”
mentioning
confidence: 99%
“…Furthermore, laboratory cynomolgus monkeys of Mauritian origin have been shown to have less genetic diversity than cynomolgus monkeys from across other areas of Asia. 24 Based on these observations, it may be concluded that an IgE antibody therapy introduced into a cynomolgus monkey may not engage in the breadth of binding and functional response seen in the human setting.…”
Section: Discussionmentioning
confidence: 99%