The Genetic Codes: Mathematical Formulae and an Inverse Symmetry-Information Relationship

Négadi, Tidjani

doi:10.3390/info8010006

Cited by 2 publications

(2 citation statements)

References 23 publications

(30 reference statements)

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“…Plethora of contributions are dedicated towards characterizing genes through the light of numerical representations [15,19,20,21]. Numeric representation of each type of multiplet signies the number of codons code for that particular amino acid.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Codon Alternation Patterns in Genetic Diseases through Numerical Representation and Codon Classification

Sengupta¹,

Choudhury

Chakraborty

et al. 2020

Preprint

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Motivation: Alteration of amino acid is possible due to mutation in codons that could have a potential impact in a diseased condition. Effective mutation analysis can help to predict the fate of the diseased individual which can be validated later by in-vitro experimentations. It may also help an individual who is asymptomatic but having a particular genetic change for early detection and diagnosis during any terminal diseases. We try to investigate the codon alteration patterns and its impact during mutation for the genes known to be responsible for a particular disease.Results: For our current study, we consider neurodegenerative and monogenic diseases. We use numerical representation based on a determinative degree and classification of codons as well as amino acids into three different classes (Strong, Weak and Transition) for the analysis. Our analysis reveals that the strong class codons are highly mutated followed by weak and transition class. We observe that most of the mutations occur in the first or second positions in the codon rather than the third. While looking into the chemical properties of amino acid, we observe that amino acids belong to the aliphatic group are affected most during missense mutations. Our investigation further emphasises that in most of the cases the change in the determinative degree of codon due to mutation is directly proportional to the physical density property. In addition, our scheme gives a more microscopic and alternative representation of the existing codon table that helps in deciphering interesting codon alteration patterns during mutations in disease pathogenesis.

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Section: Introductionmentioning

confidence: 99%

“…A plethora of contributions are dedicated for characterizing genes through the light of numerical representations [13, 14, 15, 16]. People have tried in different ways to construct a mathematical model for similarity analysis of nucleotide sequences [17, 16, 18].…”

Section: Introductionmentioning

confidence: 99%