The Generation of Transgenic Mice Expressing Human Antibody Repertoires

Zou, Xiangang; Lan, Guo-Cheng; Osborn, Michael J.; Brüggemann, Marianne

doi:10.1007/978-3-642-01144-3_16

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Transgenic Animals For Mab Production1

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2020

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“…These animals produce fully human antibodies without the need for laboratory humanization processes. Several different strategies including yeast protoplast fusion with embryonic stem cells and pronuclear microinjection were developed to achieve transgenic animals generating human antibody repertoires (33). Oocyte microinjection of gene loci on yeast or bacterial artificial chromosomes or transfection of embryonic stem cells were used in rodents.…”

Section: Transgenic Animals For Mab Productionmentioning

confidence: 99%

A Review on The Development, Production Strategies, and Utilization of Monoclonal Antibodies

Şanlav¹,

Bekçioğlu²,

Başbınar³

2020

J Basic Clin Health Sci

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Over the last 20 years, monoclonal antibodies have become the backbone of biological therapeutics for the treatment and diagnosis of several diseases. The rising incidence of cancer and other immunologic diseases promoted the increasing investments of the global pharmaceutical industry in monoclonal antibody development. The R&D has focused on the highest efficacy which is majorly correlated with the antigenbinding specificity and the lowest immunogenicity of monoclonal antibodies. This review aims to provide a brief description and explanation of each stage in the development path of mAbs.

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Section: Transgenic Animals For Mab Productionmentioning

confidence: 99%