In recent years, there have been many interesting usages for differential subordinations of analytic functions in Geometric Function Theory of Complex Analysis. The concept of the first and second-order differential subordination have been pioneered by Miller and Mocanu. In 2011, the third-order differential subordination were defined to give a new generalization to the concept of differential subordination. While the fourth-order differential subordination has been introduced in 2020. In the present article, we introduce new concept that is the Kth-order differential subordination of analytic functions in the open unit disk U.