1946
DOI: 10.1016/0021-8707(46)90148-7
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The general adaptation syndrome and the diseases of adaptation

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Cited by 191 publications
(200 citation statements)
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“…Although there are some positive influences, stressors result in many harmful actions to the stressed bodies such as the disrupted reproductive system. The stress response is comprised of the physiological adjustments made to compensate for the stressor and preserve balance of the internal milieu of the body [5]. An over abundance of glucocorticoid activity is the hallmark of stress [4].…”
Section: Stress and Leydig Cell Functionmentioning
confidence: 99%
“…Although there are some positive influences, stressors result in many harmful actions to the stressed bodies such as the disrupted reproductive system. The stress response is comprised of the physiological adjustments made to compensate for the stressor and preserve balance of the internal milieu of the body [5]. An over abundance of glucocorticoid activity is the hallmark of stress [4].…”
Section: Stress and Leydig Cell Functionmentioning
confidence: 99%
“…This was first documented by Selye in rats, when he described the chronologic development of the nonspecific response to stressors when their action is prolonged. He termed this the GAS (Selye, 1936(Selye, , 1951(Selye, , 1955(Selye, , 1976, which involved a triphasic response: (i) the alarm reaction, in which adaptation has not yet been acquired; (ii) the stage of resistance, in which adaptation is optimum; and (iii) the stage of exhaustion, in which the acquired adaptation is lost (Selye, 1955). Selye subsequently described diseases of adaptation, including psychosomatic diseases as well as immunologic and inflammatory diseases, which depended primarily on excessive or inappropriate responses to stressors, where an essentially useful defensive reaction (e.g., HPA axis activation or emotional arousal in preparation for fight) can be the major cause of disease if the defense is inappropriate under the circumstances (Selye, 1976).…”
Section: Stress Dysregulation In Neuroactive Steroids: Implications Fmentioning
confidence: 99%
“…There has been a lot of interest in stress since the groundbreaking work by Selye (1946). A considerable amount of research has focused on the body's general adaptation to acute and chronic stress, especially the effect of stress on the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, and immunity, as well as various psychological and social parameters (Sternberg et al, 1989a, b;van de Langerijt et al, 1994).…”
Section: Introductionmentioning
confidence: 99%