The gastrointestinal absorption of PRD‐92 Ea, a new anti‐allergy drug.

Abstract

1 The absorption of PRD‐92 Ea, a new anti‐allergy drug, was studied in volunteer subjects. 2 The 14C‐labelled drug was administered orally and the radioactivity measured in plasma, urine and faeces. 3 Mean peak plasma concentration was 3.3 micrograms/ml, with a concentration of over 1 micrograms/ml maintained 4 h after administration. 4 The mean plasma half‐life (T 1/2) was 114 min. 5 The mean percentage recovery in the urine was 9.5%. 6 Oral administration leads to significant and sustained plasma concentrations, and the oral route should be suitable for drug evaluation in clinical practice.

Anti-Allergy Properties of PRD-92 E_a in Guinea Pig and Rat

“…This com pound has the additional property of being well absorbed following oral administration in rat and monkey [4,5,10] and in man [6]. On the basis of in vitro studies, it has been reported that Ea is an antagonist of several putative mediators of asthma and in flammation [8], indicating that this com pound may be grouped with other anti allergy drugs having a mixed antagonist/anti allergy action, e.g.…”